Q2KIG5
Gene name |
TBXAS1 (CYP5A1) |
Protein name |
Thromboxane-A synthase |
Names |
TXA synthase, TXS, Cytochrome P450 5A1, Hydroperoxy icosatetraenoate dehydratase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:509326 |
EC number |
4.2.1.152: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KIG5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIG5-F1 | Predicted | AlphaFoldDB |
No variants for Q2KIG5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2KIG5 | |||||
No associated diseases with Q2KIG5
1 regional properties for Q2KIG5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 472 - 481 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.152 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 12-hydroxyheptadecatrienoic acid synthase activity | Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA). |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| hydroperoxy icosatetraenoate dehydratase activity | A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O. |
| iron ion binding | Binding to an iron (Fe) ion. |
| monooxygenase activity | Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. |
| thromboxane-A synthase activity | Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| icosanoid metabolic process | The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. |
| prostaglandin biosynthetic process | The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P79102 | CYP3A28 | Cytochrome P450 3A28 | Bos taurus (Bovine) | PR |
| Q9V776 | Cyp317a1 | Probable cytochrome P450 317a1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V4U9 | Cyp6a13 | Probable cytochrome P450 6a13 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V773 | Cyp6a20 | Probable cytochrome P450 6a20 | Drosophila melanogaster (Fruit fly) | PR |
| Q9V4U7 | Cyp6a14 | Probable cytochrome P450 6a14 | Drosophila melanogaster (Fruit fly) | PR |
| Q9VG82 | Cyp9f2 | Probable cytochrome P450 9f2 | Drosophila melanogaster (Fruit fly) | PR |
| P24557 | TBXAS1 | Thromboxane-A synthase | Homo sapiens (Human) | PR |
| P36423 | Tbxas1 | Thromboxane-A synthase | Mus musculus (Mouse) | PR |
| Q27513 | cyp-13A4 | Putative cytochrome P450 CYP13A4 | Caenorhabditis elegans | PR |
| Q27519 | cyp-13A7 | Putative cytochrome P450 CYP13A7 | Caenorhabditis elegans | PR |
| Q27518 | cyp-13A2 | Putative cytochrome P450 CYP13A2 | Caenorhabditis elegans | PR |
| Q09653 | cyp-13A10 | Putative cytochrome P450 CYP13A10 | Caenorhabditis elegans | PR |
| B9DFU2 | CYP711A1 | Cytochrome P450 711A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEVLGLFRLE | VSGPMVTVAL | SVVFLALLKW | YSTSAFSRLE | KLGIRHPKPS | PFIGNLAFFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QGFWESHMEL | RKQYGPLSGY | YLGRLMFIVI | SEPDMIEQVL | VEKFSNFTNR | MATGLEPKPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADSVLFLRDK | RWEEVRSVLT | VAFSPEKLSE | MTPLISRACD | VLLAHLERHA | QSGEAFDIQR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TYCCYTTDVV | ASVAFGTEVN | SQEAPEHPFV | EHCRRFFASS | IPKPLLVLLL | SFPSIMVPLA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RILPNKNRDE | LNGFFNKLIR | NVIALRDQQA | AEERRRDFLQ | MVQDVRHSAA | TVGVEKFDIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RQVFSATKCP | ANPPRRHSPR | PLSKPLSVDE | VVGQAFIFLI | AGYEIVTNTL | SFATYLLATN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PECQEKLLEE | VDCFSKEHLA | PEYCSLQEGL | PYLDMVIKET | LRMYPPAFRF | TRVAAQDCEV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LGQRIPAGAV | LETAVGALHY | DPEHWPNPEN | FNPERFTAEA | QQRRRPYTYL | PFGAGPRSCL |
| 490 | 500 | 510 | 520 | 530 | |
| GVRLGLLELK | LTLLHILRKF | RFEACPETQV | PLQLESKSAL | GPKNGVYIRI | VSR |