AiPD: Autoinhibited Protein Database

Gene name	Tbxas1 (Cyp5, Cyp5a1)
Protein name	Thromboxane-A synthase
Names	TS, TXA synthase, TXS, Cytochrome P450 5A1, Hydroperoxy icosatetraenoate dehydratase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:21391
EC number	4.2.1.152: Hydro-lyases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

270-349 (Predicted disordered autoinhibitory region) PR

270-349 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P36423-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs221767805	6	L>F	No	EVA
rs261432025	23	A>T	No	EVA
rs3388827178	47	P>S	No	EVA
rs3388823196	49	P>S	No	EVA
rs3388827215	57	M>T	No	EVA
rs231540885	88	V>I	No	EVA
rs249444866	103	N>K	No	EVA
rs3388802245	110	R>I	No	EVA
rs3388822114	117	P>L	No	EVA
rs3388830699	139	L>M	No	EVA
rs246506367	163	V>M	No	EVA
rs261297529	175	A>T	No	EVA
rs254905548	180	R>S	No	EVA
rs214517027	215	R>H	No	EVA
rs3388814186	240	A>S	No	EVA
rs3388806557	250	E>D	No	EVA
rs3388802295	272	E>D	No	EVA
rs3388802287	276	R>T	No	EVA
rs3388815936	298	D>G	No	EVA
rs3388827265	302	E>K	No	EVA
rs213788127	303	S>A	No	EVA
rs3413058574	310	T>A	No	EVA
rs4225816	314	P>S	No	EVA
rs3388810542	318	H>Q	No	EVA
rs4225818	345	V>I	No	EVA
rs3388802322	380	A>T	No	EVA
rs3388806484	413	E>K	No	EVA
rs3396590126	417	D>H	No	EVA
rs3396499697	419	E>D	No	EVA
rs3396651341	420	V>L	No	EVA
rs232192557	429	T>A	No	EVA
rs213946091	447	N>H	No	EVA
rs212052345	461	R>Q	No	EVA
rs3388810609	468	T>I	No	EVA
rs3388815879	470	L>M	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Cytochrome P450, conserved site	428 - 437	IPR017972

		Description
EC Number	4.2.1.152	Hydro-lyases
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
12-hydroxyheptadecatrienoic acid synthase activity	Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA).
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
hydroperoxy icosatetraenoate dehydratase activity	A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O.
iron ion binding	Binding to an iron (Fe) ion.
monooxygenase activity	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
thromboxane-A synthase activity	Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2).

Name	Definition
cellular chloride ion homeostasis	Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.
icosanoid metabolic process	The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.
positive regulation of vasoconstriction	Any process that activates or increases the frequency, rate or extent of vasoconstriction.
prostaglandin biosynthetic process	The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
response to ethanol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to fatty acid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P79102	CYP3A28	Cytochrome P450 3A28	Bos taurus (Bovine)	PR
Q2KIG5	TBXAS1	Thromboxane-A synthase	Bos taurus (Bovine)	PR
Q9VG82	Cyp9f2	Probable cytochrome P450 9f2	Drosophila melanogaster (Fruit fly)	PR
Q9V776	Cyp317a1	Probable cytochrome P450 317a1	Drosophila melanogaster (Fruit fly)	PR
Q9V4U9	Cyp6a13	Probable cytochrome P450 6a13	Drosophila melanogaster (Fruit fly)	PR
Q9V773	Cyp6a20	Probable cytochrome P450 6a20	Drosophila melanogaster (Fruit fly)	PR
Q9V4U7	Cyp6a14	Probable cytochrome P450 6a14	Drosophila melanogaster (Fruit fly)	PR
P24557	TBXAS1	Thromboxane-A synthase	Homo sapiens (Human)	PR
Q27513	cyp-13A4	Putative cytochrome P450 CYP13A4	Caenorhabditis elegans	PR
Q27519	cyp-13A7	Putative cytochrome P450 CYP13A7	Caenorhabditis elegans	PR
Q27518	cyp-13A2	Putative cytochrome P450 CYP13A2	Caenorhabditis elegans	PR
Q09653	cyp-13A10	Putative cytochrome P450 CYP13A10	Caenorhabditis elegans	PR
B9DFU2	CYP711A1	Cytochrome P450 711A1	Arabidopsis thaliana (Mouse-ear cress)	PR