Q2KIA1
Gene name |
RCAN3 (DSCR1L2) |
Protein name |
Calcipressin-3 |
Names |
Down syndrome candidate region 1-like protein 2, Regulator of calcineurin 3 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:506601 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KIA1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIA1-F1 | Predicted | AlphaFoldDB |
32 variants for Q2KIA1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs110551304 | 7 | N>K | No | EVA | |
| rs211056202 | 34 | D>G | No | EVA | |
| rs432760563 | 40 | M>I | No | EVA | |
| rs474945737 | 108 | H>Y | No | EVA | |
| rs466153902 | 124 | V>A | No | EVA | |
| rs434970548 | 124 | V>I | No | EVA | |
| rs449390219 | 125 | Q>K | No | EVA | |
| rs436129794 | 126 | M>R | No | EVA | |
| rs467424321 | 127 | S>T | No | EVA | |
| rs450490569 | 127 | S>Y | No | EVA | |
| rs445113628 | 128 | G>A | No | EVA | |
| rs458847585 | 128 | G>C | No | EVA | |
| rs459587924 | 129 | E>G | No | EVA | |
| rs442584964 | 130 | T>A | No | EVA | |
| rs443638110 | 134 | S>T | No | EVA | |
| rs471577323 | 136 | L>F | No | EVA | |
| rs451904160 | 137 | Q>E | No | EVA | |
| rs435097584 | 141 | P>A | No | EVA | |
| rs455947437 | 142 | A>P | No | EVA | |
| rs435758856 | 148 | S>P | No | EVA | |
| rs450464884 | 170 | D>A | No | EVA | |
| rs435149335 | 182 | E>D | No | EVA | |
| rs476535631 | 198 | V>G | No | EVA | |
| rs432954939 | 201 | C>R | No | EVA | |
| rs464144776 | 204 | E>G | No | EVA | |
| rs447396154 | 206 | E>D | No | EVA | |
| rs434114556 | 208 | E>K | No | EVA | |
| rs468683411 | 213 | N>T | No | EVA | |
| rs448414482 | 219 | T>P | No | EVA | |
| rs483041340 | 225 | E>D | No | EVA | |
| rs714780965 | 227 | P>L | No | EVA | |
| rs477602141 | 238 | D>E | No | EVA |
No associated diseases with Q2KIA1
No regional properties for Q2KIA1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q2KIA1 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium-dependent protein serine/threonine phosphatase regulator activity | Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. |
| nucleic acid binding | Binding to a nucleic acid. |
| phosphatase binding | Binding to a phosphatase. |
| troponin I binding | Binding to troponin I, the inhibitory subunit of the troponin complex. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P36054 | RCN1 | Calcipressin-like protein | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3ZC15 | RCAN2 | Calcipressin-2 | Bos taurus (Bovine) | PR |
| Q5ZJV6 | RCAN3 | Calcipressin-3 | Gallus gallus (Chicken) | PR |
| A5A6I8 | RCAN2 | Calcipressin-2 | Pan troglodytes (Chimpanzee) | PR |
| Q14206 | RCAN2 | Calcipressin-2 | Homo sapiens (Human) | PR |
| Q9UKA8 | RCAN3 | Calcipressin-3 | Homo sapiens (Human) | PR |
| Q9JHG2 | Rcan2 | Calcipressin-2 | Mus musculus (Mouse) | PR |
| Q9JKK0 | Rcan3 | Calcipressin-3 | Mus musculus (Mouse) | PR |
| Q8CH27 | Rcan2 | Calcipressin-2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRDTMNSWN | DSQSDLCSTD | HEEEEEMVFG | ENEDDLEEMM | DLSDLPTSLF | ACRVHEAVFE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPEQKERFEA | LFTIYDDQVT | FQLFKSFRRV | RINFSKPEAA | ARARIELHET | DFNGRKLKLY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FAQVQMSGET | RDKSYLQPPQ | PAKQFLISPP | ASPPVGWKQG | GDATPVINYD | LLCAVSKLGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GEKYELHAGT | ESTPSVVVHV | CESETEEEEE | TKNPKQKITQ | TRRPEPPTAA | LSEPRAFDCA |
| L |