Q19537
PR
Gene name |
rpa-1 |
Protein name |
Probable replication factor A 73 kDa subunit |
Names |
RP-A p73, Replication factor A protein 1, RF-A protein 1 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F18A1.5 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q19537
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q19537-F1 | Predicted | AlphaFoldDB |
No variants for Q19537
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q19537 | |||||
No associated diseases with Q19537
4 regional properties for Q19537
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type | 237 - 320 | IPR004365 |
| domain | Replication factor A, C-terminal | 498 - 642 | IPR013955 |
| domain | Replication protein A, OB domain | 351 - 439 | IPR031657 |
| domain | Replication factor A, C-terminal, eukaryotes | 481 - 648 | IPR047192 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA replication factor A complex | A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| damaged DNA binding | Binding to damaged DNA. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| metal ion binding | Binding to a metal ion. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
| single-stranded telomeric DNA binding | Binding to single-stranded telomere-associated DNA. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| DNA unwinding involved in DNA replication | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. |
| double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| nucleotide-excision repair | A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). |
| positive regulation of helicase activity | Any process that activates or increases the activity of a helicase. |
| positive regulation of nematode male tail tip morphogenesis | Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis. |
| telomere maintenance via telomerase | The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZJJ2 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Gallus gallus (Chicken) | PR |
| Q24492 | RpA-70 | Replication protein A 70 kDa DNA-binding subunit | Drosophila melanogaster (Fruit fly) | PR |
| P27694 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | Homo sapiens (Human) | PR |
| Q8VEE4 | Rpa1 | Replication protein A 70 kDa DNA-binding subunit | Mus musculus (Mouse) | PR |
| Q10Q08 | RPA1B | Replication protein A 70 kDa DNA-binding subunit B | Oryza sativa subsp japonica (Rice) | PR |
| F4JSG3 | RPA1E | Replication protein A 70 kDa DNA-binding subunit E | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SKI4 | RPA1A | Replication protein A 70 kDa DNA-binding subunit A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5FW17 | rpa1 | Replication protein A 70 kDa DNA-binding subunit | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAIHINHDV | FNKYHTNGKL | RLTTGYVQEA | IENNGYPGHD | GIVQVLKGKV | EQGEQLGHAF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TFRIRISDGV | FQYNALMSAD | IDDQIKREVE | HLVEGTIIAL | TKFEIYDQGE | GAKNCFLIKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YKILSRYHQV | LTSPEVKPRS | HSGKPDEHKG | YRPNIIIEDV | WPEAEGMAAD | YQENMANPPA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKAPKREFGE | EASYNRAAAP | EATRARAVPP | PARRTASNTE | RGVMPIAMVT | PYVSNFKIHG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVSRKEEIRT | FPAKNTKVFN | FEITDSNGDT | IRCTAFNEVA | ESLYTTITEN | LSYYLSGGSV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KQANKKFNNT | GHDYEITLRS | DSIIEAGGEL | LAAPKLILKR | VKLGEIAGYA | GQLIDVLVVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EKMDPEATEF | TSKAGKSLIK | REMELIDESG | ALVRLTLWGD | EATKALVDDY | VQKVIAFKGV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IPREFNGGFS | LGTGSATRII | SVPEIAGVSE | LYDWYANVKP | TTEVKMMSQA | AGGSNEAPRT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IAGLQEMQFG | KDSDKGDYAT | VKAMITRVNP | TNALYRGCAS | EGCQKKLVGE | NGDYRCEKCN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KNMNKFKWLY | MMQFELSDET | GQVYVTAFGD | SAAKIVGKSA | AELGELHDES | PDEYNAIFER |
| 610 | 620 | 630 | 640 | 650 | |
| LQFVPKMWRL | RCKMDSYNEE | VRQKMTVYGV | DDVNQDKYIE | NLKQMIEQMQ | QMSDY |