AiPD: Autoinhibited Protein Database

Gene name	TMEFF2
Protein name	Tomoregulin-2
Names	TR-2, Transmembrane protein with EGF-like and two follistatin-like domains
Species	Bos taurus (Bovine)
KEGG Pathway	bta:538354
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

104-285 (Predicted disordered autoinhibitory region) PR

104-285 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q17QD6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs460895239	5	E>G	No	EVA
rs460335595	10	C>W	No	EVA
rs438559153	12	S>T	No	EVA
rs471379915	14	T>R	No	EVA
rs462702241	17	E>*	No	EVA
rs480247898	18	G>C	No	EVA
rs480247898	18	G>S	No	EVA
rs454918921	28	M>R	No	EVA
rs436524252	43	T>P	No	EVA
rs432566700	51	P>R	No	EVA
rs454272815	51	P>T	No	EVA
rs465522488	55	N>D	No	EVA
rs450418336	55	N>K	No	EVA
rs481400725	178	V>G	No	EVA
rs448236438	178	V>I	No	EVA
rs440374960	179	W>S	No	EVA
rs483147536	202	Y>S	No	EVA
rs448804868	226	R>Q	No	EVA
rs522246922	270	N>S	No	EVA
rs476947300	299	H>P	No	EVA
rs525754313	323	A>P	No	EVA
rs518270832	331	I>M	No	EVA

Type	Name	Position	InterPro Accession
domain	EGF-like domain	261 - 301	IPR000742
domain	Kazal domain	90 - 137	IPR002350-1
domain	Kazal domain	181 - 229	IPR002350-2

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
No GO annotations for molecular function

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of integrin biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.
negative regulation of stress fiber assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
wound healing, spreading of cells	The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P50291	FST	Follistatin	Bos taurus (Bovine)	PR
Q90844	FST	Follistatin	Gallus gallus (Chicken)	PR
Q9UIK5	TMEFF2	Tomoregulin-2	Homo sapiens (Human)	PR
Q9QYM9	Tmeff2	Tomoregulin-2	Mus musculus (Mouse)	PR