P50291
PR
Gene name |
FST |
Protein name |
Follistatin |
Names |
FS, Activin-binding protein |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:327681 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P50291
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P50291-F1 | Predicted | AlphaFoldDB |
75 variants for P50291
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs471433682 | 29 | A>D | No | EVA | |
| rs453614161 | 31 | N>D | No | EVA | |
| rs440202868 | 35 | R>P | No | EVA | |
| rs441520233 | 50 | L>R | No | EVA | |
| rs474542657 | 51 | S>G | No | EVA | |
| rs455821772 | 71 | N>K | No | EVA | |
| rs437399595 | 72 | D>N | No | EVA | |
| rs470060843 | 73 | N>K | No | EVA | |
| rs451736716 | 81 | F>C | No | EVA | |
| rs433135113 | 84 | G>A | No | EVA | |
| rs466034979 | 89 | I>L | No | EVA | |
| rs446709083 | 91 | C>G | No | EVA | |
| rs457963815 | 114 | P>S | No | EVA | |
| rs444363318 | 138 | T>P | No | EVA | |
| rs524655291 | 156 | L>P | No | EVA | |
| rs524259625 | 191 | T>A | No | EVA | |
| rs481524396 | 206 | L>F | No | EVA | |
| rs471025146 | 212 | V>E | No | EVA | |
| rs451600947 | 213 | T>A | No | EVA | |
| rs474732427 | 245 | C>W | No | EVA | |
| rs714151305 | 247 | D>N | No | EVA | |
| rs462550986 | 248 | I>T | No | EVA | |
| rs444207722 | 250 | C>* | No | EVA | |
| rs452159638 | 254 | K>N | No | EVA | |
| rs439979372 | 255 | K>E | No | EVA | |
| rs473008670 | 255 | K>M | No | EVA | |
| rs439979372 | 255 | K>Q | No | EVA | |
| rs455201336 | 256 | C>R | No | EVA | |
| rs436657940 | 261 | K>R | No | EVA | |
| rs109247499 | 275 | P>A | No | EVA | |
| rs798890911 | 276 | E>K | No | EVA | |
| rs457485103 | 277 | S>C | No | EVA | |
| rs457485103 | 277 | S>G | No | EVA | |
| rs432545985 | 277 | S>R | No | EVA | |
| rs479836045 | 288 | N>K | No | EVA | |
| rs446940377 | 288 | N>S | No | EVA | |
| rs467716900 | 293 | S>R | No | EVA | |
| rs524729392 | 296 | A>V | No | EVA | |
| rs449284962 | 297 | M>I | No | EVA | |
| rs481081177 | 304 | S>L | No | EVA | |
| rs462687859 | 311 | K>R | No | EVA | |
| rs470006303 | 318 | S>C | No | EVA | |
| rs432833259 | 319 | I>M | No | EVA | |
| rs451416211 | 319 | I>V | No | EVA | |
| rs447189579 | 320 | S>L | No | EVA | |
| rs465834047 | 320 | S>P | No | EVA | |
| rs480062903 | 321 | E>A | No | EVA | |
| rs480062903 | 321 | E>V | No | EVA | |
| rs468694064 | 322 | D>A | No | EVA | |
| rs450329509 | 322 | D>E | No | EVA | |
| rs483151582 | 323 | T>N | No | EVA | |
| rs458314141 | 324 | E>D | No | EVA | |
| rs446216609 | 325 | D>E | No | EVA | |
| rs479112493 | 326 | E>D | No | EVA | |
| rs442032485 | 327 | E>A | No | EVA | |
| rs460646551 | 327 | E>Q | No | EVA | |
| rs475036248 | 331 | D>G | No | EVA | |
| rs462020345 | 332 | Q>P | No | EVA | |
| rs443516106 | 333 | D>A | No | EVA | |
| rs476531160 | 334 | Y>N | No | EVA | |
| rs451441827 | 334 | Y>S | No | EVA | |
| rs432980353 | 335 | S>T | No | EVA | |
| rs453780659 | 337 | P>L | No | EVA | |
| rs435136443 | 338 | I>L | No | EVA | |
| rs468032029 | 339 | S>F | No | EVA | |
| rs449609038 | 340 | S>C | No | EVA | |
| rs438221367 | 341 | I>F | No | EVA | |
| rs438221367 | 341 | I>L | No | EVA | |
| rs464830465 | 341 | I>N | No | EVA | |
| rs460639770 | 343 | E>G | No | EVA | |
| rs479292823 | 343 | E>K | No | EVA | |
| rs448628532 | 344 | W>G | No | EVA | |
| rs481537377 | 344 | W>L | No | EVA | |
| rs462917798 | 345 | W>E | No | EVA | |
| rs462917798 | 345 | W>K | No | EVA |
No associated diseases with P50291
8 regional properties for P50291
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Kazal domain | 117 - 166 | IPR002350-1 |
| domain | Kazal domain | 190 - 241 | IPR002350-2 |
| domain | Kazal domain | 261 - 318 | IPR002350-3 |
| domain | Follistatin-like, N-terminal | 94 - 117 | IPR003645-1 |
| domain | Follistatin-like, N-terminal | 167 - 190 | IPR003645-2 |
| domain | Follistatin-like, N-terminal | 244 - 268 | IPR003645-3 |
| domain | Follistatin/Osteonectin EGF domain | 95 - 116 | IPR015369 |
| domain | TB domain | 30 - 91 | IPR017878 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| activin binding | Binding to activin, a dimer of inhibin-beta subunits. |
| activin receptor antagonist activity | Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| ameloblast differentiation | The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ. |
| BMP signaling pathway | The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| female gonad development | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. |
| gamete generation | The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. |
| hair follicle morphogenesis | The process in which the anatomical structures of the hair follicle are generated and organized. |
| hematopoietic progenitor cell differentiation | The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. |
| keratinocyte proliferation | The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. |
| negative regulation of activin receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway. |
| negative regulation of epithelial cell differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| odontogenesis of dentin-containing tooth | The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. |
| pattern specification process | Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. |
| positive regulation of hair follicle development | Any process that activates or increases the frequency, rate or extent of hair follicle development. |
| regulation of BMP signaling pathway | Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. |
| skeletal system development | The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARPRHQPGG | LCLLLLLLCQ | FMEDRSAQAG | NCWLRQAKNG | RCQVLYKTEL | SKEECCSTGR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSTSWTEEDV | NDNTLFKWMI | FNGGAPNCIP | CKETCENVDC | GPGKKCRMNK | KNKPRCVCAP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DCSNITWKGP | VCGLDGKTYR | NECALLKARC | KEQPELQVQY | QGKCKKTCRD | VFCPGSSTCV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VDQTNNAYCV | TCNRICPEPT | SSEQYLCGND | GVTYPSACHL | RKATCLLGRS | IGLAYEGKCI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KAKSCDDIQC | TGGKKCLWDF | KVGRGRCSLC | GELCPESKSE | EPVCASDNAT | YASECAMKEA |
| 310 | 320 | 330 | 340 | ||
| ACSSGVLLEV | KHSGSCNSIS | EDTEDEEEDE | DQDYSFPISS | ILEW |