Q155U0

PR
Gene name
vps51 (ffr)
Protein name
Vacuolar protein sorting-associated protein 51 homolog
Names
Protein fat-free
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:559339
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q155U0

Entry ID Method Resolution Chain Position Source
AF-Q155U0-F1 Predicted AlphaFoldDB

No variants for Q155U0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q155U0

No associated diseases with Q155U0

1 regional properties for Q155U0

Type Name Position InterPro Accession
domain Exocyst complex component EXOC2/Sec5, N-terminal domain 46 - 272 IPR039481

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus, trans-Golgi network
  • Recycling endosome
  • Also localizes in perinuclear region (PubMed:16581006)
  • Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
EARP complex A quatrefoil tethering complex required for endocytic recycling.
GARP complex A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

1 GO annotations of molecular function

Name Definition
small GTPase binding Binding to a small monomeric GTPase.

9 GO annotations of biological process

Name Definition
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
lipid digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lysosomal transport The directed movement of substances into, out of or within a lysosome.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of phospholipase activity Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QQ47 VPS51 Vacuolar protein sorting-associated protein 51 homolog Bos taurus (Bovine) PR
Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog Homo sapiens (Human) PR
Q3UVL4 Vps51 Vacuolar protein sorting-associated protein 51 homolog Mus musculus (Mouse) PR
Q4V9Y0 vps51 Vacuolar protein sorting-associated protein 51 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSSATTPPDS DPAQRRRVHS MLKLYYGLNE EGKATEQAES LDPCDINGPH FDPEIYLNKL
70 80 90 100 110 120
RKECSLTELM DHESCMVKQI RSLDSDMQTL VYENYNKFIS ATDTIRKMKN DFKKMEDEMD
130 140 150 160 170 180
CLSANMAAIT EFSARISGTL QDQHAQITKL SGVHTLLRKL QFLFELPARL NKCLELQAYA
190 200 210 220 230 240
QAVSSHRRAR CVLQQYSHMP SFRGIQDDCH VIMEQLAQQL RQKFRDGGSS AKDLSECVEL
250 260 270 280 290 300
LLQLDEPAEE LCDKFLSHAQ SRLEADLQGL EAELKDSAVT DTGAGSVQKT SPGSNPVSPS
310 320 330 340 350 360
SSVSNPFLSP AAGTDILEFI DRGCNEFVSN LCLVIASYQE LFINRPQESE LASKNIPEMA
370 380 390 400 410 420
NGKLHVFVDT LAARYFSLVE RRIQEEKGVG DNSLLVRALD RFHRRLQAIS KLLPGSAVPS
430 440 450 460 470 480
QGTEIVVRAA RERIKQYLSA LQTFYHDSLT DVRQALAAPR LSVGGASASG GGALVGGASS
490 500 510 520 530 540
KDAPPSLPEL LTSLSNFILN QLKSVLASVH LFTAKDITFS NKPYFKGEFC SQGVREGLVV
550 560 570 580 590 600
SFIKFICQSS RQYCESAGDR GGSTPPALLL LLSRLCLDYE TSTISYILTL TDEQFLVQHH
610 620 630 640 650 660
TPVTPVTALC AEAREAAQKL LNHYVKVQGL IISQMLRKSV ETRDWVNTIE PRNVRAVMKR
670 680 690 700 710 720
VVEDTTSIDV QVGLLYEEGV RKAHSSDSSK RTFSVYSSSR QQIRYAPSYT PSAPMDTNLL
730 740 750 760 770 780
SNIHKLFSER IDIFSPVEFN KVSVLTGIIK ISLKTFLECV RLRTFGRYGL QQIQVDCHYL
790 800 810 820
QMYLWRFVSD ENLVHFLLDE IVGSAAHRCL DPSPMEQSVI EVICERG