A6QQ47

PR
Gene name
VPS51 (FFR)
Protein name
Vacuolar protein sorting-associated protein 51 homolog
Names
Protein fat-free homolog
Species
Bos taurus (Bovine)
KEGG Pathway
bta:525567
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QQ47

Entry ID Method Resolution Chain Position Source
AF-A6QQ47-F1 Predicted AlphaFoldDB

No variants for A6QQ47

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6QQ47

No associated diseases with A6QQ47

No regional properties for A6QQ47

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A6QQ47

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus, trans-Golgi network
  • Recycling endosome
  • Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
EARP complex A quatrefoil tethering complex required for endocytic recycling.
GARP complex A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name Definition
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lysosomal transport The directed movement of substances into, out of or within a lysosome.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog Homo sapiens (Human) PR
Q3UVL4 Vps51 Vacuolar protein sorting-associated protein 51 homolog Mus musculus (Mouse) PR
Q4V9Y0 vps51 Vacuolar protein sorting-associated protein 51 homolog Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q155U0 vps51 Vacuolar protein sorting-associated protein 51 homolog Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAAAAAAPGP GSGPGDSPEG PEAEGPERRR KAHGMLKLYY GLSEGEAAGR PSGPDPLDPT
70 80 90 100 110 120
DLNGAHFDPE VYLDKLRREC PLAQLMDSET DMVRQIRALD SDMQTLVYEN YNKFISATDT
130 140 150 160 170 180
IRKMKNDFRK MEDEMDRLAT NMAVITDFSA RISATLQDPH ERITKLAGVH ALLRKLQILF
190 200 210 220 230 240
ELPSRLTKCV ELGAYGQAVR YQGRARAVLQ QYQHLPSFRA IQDDCQVITA RLAQQLRQRF
250 260 270 280 290 300
REGGSGAPEQ AECVELLLAL GEPAEELCEE FLAHARGRLE EELRSLEAEL GPSPLAPDVL
310 320 330 340 350 360
EFTDHGGSGF VGGLCQVAAA YQELFAAQGP AGAEKLAAFA RELGSRYFAL VERRLAQEQG
370 380 390 400 410 420
SGDNSLLVRA LDRFHRRLRA PGALLAAAGL AEAATEIVER VARERLGHHL QGLQAAFLGS
430 440 450 460 470 480
LTDVRQALAA PRIAGKEGPG LAELLANVAS SILSHIKASL ASVHLFTAKE VSFSNKPYFR
490 500 510 520 530 540
GEFCSQGVRE SLIVGFIRSM CQTAQSFCDS PGEKGGATPP ALLLLLSRLC LDYETATISY
550 560 570 580 590 600
ILTLTDEQFL VQDQSPVTPV STLCAEARET ARRLLTHYVK VQGLVISQML RKSVETRDWL
610 620 630 640 650 660
STLEPRNVRA VMKRVVEDTT AIDVQVGLLY EEGVRKAQSS DSSKRTFSVY SSSRQQGRYA
670 680 690 700 710 720
PSYTPSAPMD TNLLSNIQKL FSERIDVFSP VEFNKVSVLT GIIKISLKTL LECVRLRTFG
730 740 750 760 770 780
RFGLQQVQVD CHFLQLYLWR FVADEELVHL LLDEVVASAA LRCPDPVPME PSVVEVICER
G