Q08C99

PR
Gene name
vrtn (si:ch211-146n9.1, si:dkey-1h6.4, zgc:153349)
Protein name
Vertnin
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:555269
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

219-304 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08C99

Entry ID Method Resolution Chain Position Source
AF-Q08C99-F1 Predicted AlphaFoldDB

No variants for Q08C99

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q08C99

No associated diseases with Q08C99

1 regional properties for Q08C99

Type Name Position InterPro Accession
domain Vertnin-like, ovarian tumor domain 73 - 242 IPR047273

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.

1 GO annotations of molecular function

Name Definition
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.

2 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1BP92 VRTN Vertnin Bos taurus (Bovine) PR
D2GZW6 VRTN Vertnin Ailuropoda melanoleuca (Giant panda) PR
Q9H8Y1 VRTN Vertnin Homo sapiens (Human) PR
Q3SYK4 Vrtn Vertnin Mus musculus (Mouse) PR
E1CHH8 VRTN Vertnin Sus scrofa (Pig) PR
10 20 30 40 50 60
MIQRAEAVLS VLGELQEATE CVGLDALTKV AVEVEQVLAP FPLPTAPCSE ISSWQGIDAV
70 80 90 100 110 120
AHRLYPGDAP TGLLPLVCKG EGNLLFDAAS MLLVGSTSLS LELQVRAVVE MLIWKRYYLC
130 140 150 160 170 180
GMIDSKVMLQ AARFSLCAEE SQDMLNLPIQ VLEAIFDADV KASCFHGSFA NMWHVYALAS
190 200 210 220 230 240
VLQCNIYSVY PMYNLKIRPY FNRLIRPRIW SKDTEPLTLH IMWSGDLEAG SVFKPHKFVA
250 260 270 280 290 300
LIHASDLKIG SPNSEQRMPL VKSLELQNQD TQLSYSNLKN KFNITKSTFY RWKRQSIEYH
310 320 330 340 350 360
KKSVARYEAK HFFLTSYKQG KLIPLSQFKE LFPEIPRSTY YAWKQELVSC CSLSGGSTGE
370 380 390 400 410 420
LSPGDSTEQD YWSSPEVKKT PGQGSFANML AFKYEKLEGE RNQNVTLMQE AKKSLQDCIV
430 440 450 460 470 480
ANTSFPYRIF KRKFPGISRS TYYNWRREAM LFIPFKEHSG SSEEGSDADK SQSPRSQMSP
490 500 510 520 530 540
SKFDRQKLSP RVRISRRKHR SLRLAYHHRK MLREEAKMHI RRSKMSFIKF KLKFPTVSSS
550 560 570 580 590 600
FYWLWRVSLN RKPEKPAVMS NSEESKSLAI SPDVFQKIKT QGMFSFDGNI DCLNGQTEFT
610 620 630 640 650 660
MPEYSPPDQS TNDHMFVMDV VALANFKAKA KLFLQQRFEE KAFPTFKEFR SYFPLTPRST
670
YYMWKRALHH GVPLIHA