Q07537

PR
Gene name
GALNT1
Protein name
Polypeptide N-acetylgalactosaminyltransferase 1
Names
Polypeptide GalNAc transferase 1, GalNAc-T1, pp-GaNTase 1, Protein-UDP acetylgalactosaminyltransferase 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282241
EC number
2.4.1.41: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q07537

Entry ID Method Resolution Chain Position Source
AF-Q07537-F1 Predicted AlphaFoldDB

44 variants for Q07537

Variant ID(s) Position Change Description Diseaes Association Provenance
rs464895156 6 Y>H No EVA
rs109846260 36 E>G No EVA
rs526420972 60 E>A No EVA
rs109500253 70 E>K No EVA
rs109500253 70 E>Q No EVA
rs134154993 77 E>D No EVA
rs475029299 82 N>H No EVA
rs454822088 92 I>S No EVA
rs520900051 94 L>R No EVA
rs137201571 113 D>N No EVA
rs133512429 139 V>I No EVA
rs137620559 142 R>H No EVA
rs437600146 198 A>P No EVA
rs110553611 205 I>T No EVA
rs477617538 256 Y>* No EVA
rs459027225 259 F>V No EVA
rs137788278 302 Y>* No EVA
rs135059336 306 I>T No EVA
rs135768969 319 E>G No EVA
rs136942957 319 E>Q No EVA
rs444366902 462 M>I No EVA
rs448216414 467 V>G No EVA
rs482843855 474 K>T No EVA
rs463019392 475 E>D No EVA
rs3423062096 476 I>S No EVA
rs439632319 477 R>G No EVA
rs134441586 477 R>S No EVA
rs477304862 478 T>P No EVA
rs460415972 480 D>N No EVA
rs440346650 482 C>S No EVA
rs475134653 482 C>W No EVA
rs455196912 483 L>F No EVA
rs444607673 486 S>C No EVA
rs444607673 486 S>F No EVA
rs432895297 494 M>K No EVA
rs464248303 495 L>P No EVA
rs453761901 496 K>Q No EVA
rs433541014 498 H>P No EVA
rs468469052 502 G>S No EVA
rs448336698 505 L>P No EVA
rs133517902 507 E>D No EVA
rs482889439 508 Y>D No EVA
rs482889439 508 Y>H No EVA
rs721298194 510 P>L No EVA

No associated diseases with Q07537

3 regional properties for Q07537

Type Name Position InterPro Accession
domain Ricin B, lectin domain 426 - 551 IPR000772
domain Glycosyltransferase 2-like 119 - 303 IPR001173
domain N-acetylgalactosaminyltransferase 119 - 419 IPR045885

Functions

Description
EC Number 2.4.1.41 Hexosyltransferases
Subcellular Localization
  • [Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

3 GO annotations of molecular function

Name Definition
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
manganese ion binding Binding to a manganese ion (Mn).
polypeptide N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.

3 GO annotations of biological process

Name Definition
protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
protein O-linked glycosylation via serine The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine.
protein O-linked glycosylation via threonine The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine.

23 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6WV16 Pgant6 N-acetylgalactosaminyltransferase 6 Drosophila melanogaster (Fruit fly) PR
Q9Y117 Pgant3 Polypeptide N-acetylgalactosaminyltransferase 3 Drosophila melanogaster (Fruit fly) PR
Q6WV17 Pgant5 Polypeptide N-acetylgalactosaminyltransferase 5 Drosophila melanogaster (Fruit fly) PR
Q9NY28 GALNT8 Probable polypeptide N-acetylgalactosaminyltransferase 8 Homo sapiens (Human) PR
Q7Z7M9 GALNT5 Polypeptide N-acetylgalactosaminyltransferase 5 Homo sapiens (Human) PR
Q86SR1 GALNT10 Polypeptide N-acetylgalactosaminyltransferase 10 Homo sapiens (Human) PR
Q8IXK2 GALNT12 Polypeptide N-acetylgalactosaminyltransferase 12 Homo sapiens (Human) PR
Q14435 GALNT3 Polypeptide N-acetylgalactosaminyltransferase 3 Homo sapiens (Human) PR
Q8IUC8 GALNT13 Polypeptide N-acetylgalactosaminyltransferase 13 Homo sapiens (Human) PR
Q49A17 GALNTL6 Polypeptide N-acetylgalactosaminyltransferase-like 6 Homo sapiens (Human) PR
Q10472 GALNT1 Polypeptide N-acetylgalactosaminyltransferase 1 Homo sapiens (Human) PR
P70419 Galnt3 Polypeptide N-acetylgalactosaminyltransferase 3 Mus musculus (Mouse) PR
Q921L8 Galnt11 Polypeptide N-acetylgalactosaminyltransferase 11 Mus musculus (Mouse) PR
Q8BGT9 Galnt12 Polypeptide N-acetylgalactosaminyltransferase 12 Mus musculus (Mouse) PR
Q8CF93 Galnt13 Polypeptide N-acetylgalactosaminyltransferase 13 Mus musculus (Mouse) PR
O08912 Galnt1 Polypeptide N-acetylgalactosaminyltransferase 1 Mus musculus (Mouse) PR
Q29121 GALNT1 Polypeptide N-acetylgalactosaminyltransferase 1 Sus scrofa (Pig) PR
Q925R7 Galnt10 Polypeptide N-acetylgalactosaminyltransferase 10 Rattus norvegicus (Rat) PR
O88422 Galnt5 Polypeptide N-acetylgalactosaminyltransferase 5 Rattus norvegicus (Rat) PR
Q6UE39 Galnt13 Polypeptide N-acetylgalactosaminyltransferase 13 Rattus norvegicus (Rat) PR
Q10473 Galnt1 Polypeptide N-acetylgalactosaminyltransferase 1 Rattus norvegicus (Rat) PR
Q7K755 gly-11 Putative polypeptide N-acetylgalactosaminyltransferase 11 Caenorhabditis elegans PR
P34678 gly-3 Polypeptide N-acetylgalactosaminyltransferase 3 Caenorhabditis elegans PR
10 20 30 40 50 60
MRKFAYCKVV LATSLIWVLL DMFLLLYFSE CNKCDEKKER GLPAGDVLEP VQKPHEGPGE
70 80 90 100 110 120
MGKPVVIPKE DQEKMKEMFK INQFNLMASE MIALNRSLPD VRLEGCKTKV YPDNLPTTSV
130 140 150 160 170 180
VIVFHNEAWS TLLRTVHSVI NRSPRHMLEE IVLVDDASER DFLKRPLESY VKKLKVPVHV
190 200 210 220 230 240
IRMEQRSGLI RARLKGAAVS KGQVITFLDA HCECTVGWLE PLLARIKHDR KTVVCPIIDV
250 260 270 280 290 300
ISDDTFEYMA GSDMTYGGFN WKLNFRWYPV PQREMDRRKG DRTLPVRTPT MAGGLFSIDR
310 320 330 340 350 360
DYFQEIGTYD AGMDIWGGEN LEISFRIWQC GGTLEIVTCS HVGHVFRKAT PYTFPGGTGQ
370 380 390 400 410 420
IINKNNRRLA EVWMDEFKNF FYIISPGVTK VDYGDISSRL GLRHKLQCRP FSWYLENIYP
430 440 450 460 470 480
DSQIPRHYFS LGEIRNVETN QCLDNMARKE NEKVGIFNCH GMGGNQVFSY TANKEIRTDD
490 500 510 520 530 540
LCLDVSKLNG PVTMLKCHHL KGNQLWEYDP VKLTLQHVNS NQCLDKATDE DSQVPSIRDC
550
SGSRSQQWLL RNVTLPEIF