O08912
PR
Gene name |
Galnt1 |
Protein name |
Polypeptide N-acetylgalactosaminyltransferase 1 |
Names |
Polypeptide GalNAc transferase 1, GalNAc-T1, pp-GaNTase 1, Protein-UDP acetylgalactosaminyltransferase 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14423 |
EC number |
2.4.1.41: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O08912
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1XHB | X-ray | 250 A | A | 88-559 | PDB |
| AF-O08912-F1 | Predicted | AlphaFoldDB |
18 variants for O08912
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs256745637 | 38 | Q>K | No | EVA | |
| rs3389489286 | 76 | K>N | No | EVA | |
| rs3389448805 | 81 | I>V | No | EVA | |
| rs3389438473 | 109 | K>Q | No | EVA | |
| rs3389490355 | 112 | P>S | No | EVA | |
| rs3389489354 | 117 | T>I | No | EVA | |
| rs3389438425 | 162 | F>L | No | EVA | |
| rs3389483029 | 170 | Y>F | No | EVA | |
| rs3407974478 | 201 | R>I | No | EVA | |
| rs3389489323 | 216 | A>S | No | EVA | |
| rs3389487350 | 326 | R>M | No | EVA | |
| rs3389457225 | 329 | Q>* | No | EVA | |
| rs3389493797 | 333 | T>I | No | EVA | |
| rs3389505903 | 333 | T>P | No | EVA | |
| rs3389457280 | 400 | L>H | No | EVA | |
| rs3389457195 | 417 | N>S | No | EVA | |
| rs3389490861 | 517 | H>P | No | EVA | |
| rs3389502399 | 534 | V>M | No | EVA |
No associated diseases with O08912
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.41 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi cisterna membrane | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| manganese ion binding | Binding to a manganese ion (Mn). |
| polypeptide N-acetylgalactosaminyltransferase activity | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein O-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. |
| protein O-linked glycosylation via serine | The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine. |
| protein O-linked glycosylation via threonine | The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine. |
25 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07537 | GALNT1 | Polypeptide N-acetylgalactosaminyltransferase 1 | Bos taurus (Bovine) | PR |
| Q6WV16 | Pgant6 | N-acetylgalactosaminyltransferase 6 | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y117 | Pgant3 | Polypeptide N-acetylgalactosaminyltransferase 3 | Drosophila melanogaster (Fruit fly) | PR |
| Q6WV17 | Pgant5 | Polypeptide N-acetylgalactosaminyltransferase 5 | Drosophila melanogaster (Fruit fly) | PR |
| Q9NY28 | GALNT8 | Probable polypeptide N-acetylgalactosaminyltransferase 8 | Homo sapiens (Human) | PR |
| Q7Z7M9 | GALNT5 | Polypeptide N-acetylgalactosaminyltransferase 5 | Homo sapiens (Human) | PR |
| Q86SR1 | GALNT10 | Polypeptide N-acetylgalactosaminyltransferase 10 | Homo sapiens (Human) | PR |
| Q8IXK2 | GALNT12 | Polypeptide N-acetylgalactosaminyltransferase 12 | Homo sapiens (Human) | PR |
| Q14435 | GALNT3 | Polypeptide N-acetylgalactosaminyltransferase 3 | Homo sapiens (Human) | PR |
| Q8IUC8 | GALNT13 | Polypeptide N-acetylgalactosaminyltransferase 13 | Homo sapiens (Human) | PR |
| Q49A17 | GALNTL6 | Polypeptide N-acetylgalactosaminyltransferase-like 6 | Homo sapiens (Human) | PR |
| Q10472 | GALNT1 | Polypeptide N-acetylgalactosaminyltransferase 1 | Homo sapiens (Human) | PR |
| P70419 | Galnt3 | Polypeptide N-acetylgalactosaminyltransferase 3 | Mus musculus (Mouse) | PR |
| Q8BGT9 | Galnt12 | Polypeptide N-acetylgalactosaminyltransferase 12 | Mus musculus (Mouse) | PR |
| Q921L8 | Galnt11 | Polypeptide N-acetylgalactosaminyltransferase 11 | Mus musculus (Mouse) | PR |
| Q80VA0 | Galnt7 | N-acetylgalactosaminyltransferase 7 | Mus musculus (Mouse) | PR |
| Q8CF93 | Galnt13 | Polypeptide N-acetylgalactosaminyltransferase 13 | Mus musculus (Mouse) | PR |
| Q8BVG5 | Galnt14 | Polypeptide N-acetylgalactosaminyltransferase 14 | Mus musculus (Mouse) | PR |
| Q29121 | GALNT1 | Polypeptide N-acetylgalactosaminyltransferase 1 | Sus scrofa (Pig) | PR |
| Q925R7 | Galnt10 | Polypeptide N-acetylgalactosaminyltransferase 10 | Rattus norvegicus (Rat) | PR |
| O88422 | Galnt5 | Polypeptide N-acetylgalactosaminyltransferase 5 | Rattus norvegicus (Rat) | PR |
| Q6UE39 | Galnt13 | Polypeptide N-acetylgalactosaminyltransferase 13 | Rattus norvegicus (Rat) | PR |
| Q10473 | Galnt1 | Polypeptide N-acetylgalactosaminyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q7K755 | gly-11 | Putative polypeptide N-acetylgalactosaminyltransferase 11 | Caenorhabditis elegans | PR |
| P34678 | gly-3 | Polypeptide N-acetylgalactosaminyltransferase 3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRKFAYCKVV | LATSLVWVLL | DMFLLLYFSE | CNKCEEKQER | GLPAGDVLEL | VQKPHEGPGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MGKPVVIPKE | DQEKMKEMFK | INQFNLMASE | MIALNRSLPD | VRLEGCKTKV | YPDNLPTTSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VIVFHNEAWS | TLLRTVHSVI | NRSPRHMIEE | IVLVDDASER | DFLKRPLESY | VKKLKVPVHV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IRMEQRSGLI | RARLKGAAVS | RGQVITFLDA | HCECTAGWLE | PLLARIKHDR | RTVVCPIIDV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ISDDTFEYMA | GSDMTYGGFN | WKLNFRWYPV | PQREMDRRKG | DRTLPVRTPT | MAGGLFSIDR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYFQEIGTYD | AGMDIWGGEN | LEISFRIWQC | GGTLEIVTCS | HVGHVFRKAT | PYTFPGGTGQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IINKNNRRLA | EVWMDEFKNF | FYIISPGVTK | VDYGDISSRL | GLRRKLQCKP | FSWYLENIYP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DSQIPRHYFS | LGEIRNVETN | QCLDNMARKE | NEKVGIFNCH | GMGGNQVFSY | TANKEIRTDD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LCLDVSKLNG | PVTMLKCHHL | KGNQLWEYDP | VKLTLQHVNS | NQCLDKATEE | DSQVPSIRDC |
| 550 | |||||
| TGSRSQQWLL | RNVTLPEIF |