Q05825
Gene name |
ATPsynbeta |
Protein name |
ATP synthase subunit beta, mitochondrial |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG11154 |
EC number |
7.1.2.2: Hydron translocation linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q05825
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q05825-F1 | Predicted | AlphaFoldDB |
No variants for Q05825
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q05825 | |||||
No associated diseases with Q05825
4 regional properties for Q05825
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain | 163 - 382 | IPR000194 |
| domain | AAA+ ATPase domain | 175 - 359 | IPR003593 |
| domain | ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain | 40 - 106 | IPR004100 |
| active_site | ATPase, alpha/beta subunit, nucleotide-binding domain, active site | 373 - 382 | IPR020003 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.1.2.2 | Hydron translocation linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial proton-transporting ATP synthase complex | A proton-transporting ATP synthase complex found in the mitochondrial membrane. |
| mitochondrial proton-transporting ATP synthase, catalytic core | The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| proton-transporting ATP synthase complex, catalytic core F(1) | The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| proton-transporting ATP synthase activity, rotational mechanism | Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out). |
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| proton motive force-driven ATP synthesis | The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. |
| proton motive force-driven mitochondrial ATP synthesis | The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00829 | ATP5F1B | ATP synthase subunit beta, mitochondrial | Bos taurus (Bovine) | PR |
| Q5ZLC5 | ATP5F1B | ATP synthase subunit beta, mitochondrial | Gallus gallus (Chicken) | PR |
| P06576 | ATP5F1B | ATP synthase subunit beta, mitochondrial | Homo sapiens (Human) | PR |
| P56480 | Atp5f1b | ATP synthase subunit beta, mitochondrial | Mus musculus (Mouse) | PR |
| P10719 | Atp5f1b | ATP synthase subunit beta, mitochondrial | Rattus norvegicus (Rat) | PR |
| P46561 | atp-2 | ATP synthase subunit beta, mitochondrial | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFALRAASKA | DKNLLPFLGQ | LSRSHAAKAA | KAAAAANGKI | VAVIGAVVDV | QFDDNLPPIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NALEVDNRSP | RLVLEVAQHL | GENTVRTIAM | DGTEGLVRGQ | KVLDTGYPIR | IPVGAETLGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IINVIGEPID | ERGPIDTDKT | AAIHAEAPEF | VQMSVEQEIL | VTGIKVVDLL | APYAKGGKIG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFGGAGVGKT | VLIMELINNV | AKAHGGYSVF | AGVGERTREG | NDLYNEMIEG | GVISLKDKTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KVALVYGQMN | EPPGARARVA | LTGLTVAEYF | RDQEGQDVLL | FIDNIFRFTQ | AGSEVSALLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RIPSAVGYQP | TLATDMGSMQ | ERITTTKKGS | ITSVQAIYVP | ADDLTDPAPA | TTFAHLDATT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VLSRAIAELG | IYPAVDPLDS | TSRIMDPNII | GQEHYNVARG | VQKILQDYKS | LQDIIAILGM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DELSEEDKLT | VARARKIQRF | LSQPFQVAEV | FTGHAGKLVP | LEQTIKGFSA | ILAGDYDHLP |
| 490 | 500 | ||||
| EVAFYMVGPI | EEVVEKADRL | AKEAA |