P61203

PR
Gene name
Cops2 (Csn2, Trip15)
Protein name
COP9 signalosome complex subunit 2
Names
SGN2, Signalosome subunit 2, Alien homolog, JAB1-containing signalosome subunit 2, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP-15
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:261736
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P61203

Entry ID Method Resolution Chain Position Source
AF-P61203-F1 Predicted AlphaFoldDB

No variants for P61203

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P61203

No associated diseases with P61203

1 regional properties for P61203

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 254 - 427 IPR000717

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

10 GO annotations of biological process

Name Definition
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
inner cell mass cell proliferation The proliferation of cells in the inner cell mass.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of nucleic acid-templated transcription Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein phosphorylation The process of introducing a phosphate group on to a protein.
skeletal muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
trophectodermal cell proliferation The proliferation of cells in the trophectoderm.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P61201 COPS2 COP9 signalosome complex subunit 2 Homo sapiens (Human) PR
P61202 Cops2 COP9 signalosome complex subunit 2 Mus musculus (Mouse) PR
O01422 csn-2 COP9 signalosome complex subunit 2 Caenorhabditis elegans PR
Q6IQT4 cops2 COP9 signalosome complex subunit 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL
70 80 90 100 110 120
EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS
130 140 150 160 170 180
TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ
190 200 210 220 230 240
TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC
250 260 270 280 290 300
GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK
310 320 330 340 350 360
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI
370 380 390 400 410 420
KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR
430 440
YTALDKWTNQ LNSLNQAVVS KLA