AiPD: Autoinhibited Protein Database

P61201

Gene name	COPS2 (CSN2, TRIP15)
Protein name	COP9 signalosome complex subunit 2
Names	SGN2, Signalosome subunit 2, Alien homolog, JAB1-containing signalosome subunit 2, Thyroid receptor-interacting protein 15, TR-interacting protein 15, TRIP-15
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9318
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-84 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

13 structures for P61201

Entry ID	Method	Resolution	Chain	Position	Source
4D10	X-ray	380 A	B/J	1-443	PDB
4D18	X-ray	408 A	B/J	1-443	PDB
4WSN	X-ray	550 A	B/J/R/Z/h/p	1-443	PDB
6A73	X-ray	245 A	A/B	29-162	PDB
6R6H	EM	840 A	B	1-443	PDB
6R7F	EM	820 A	B	1-443	PDB
6R7H	EM	880 A	B	30-443	PDB
6R7I	EM	590 A	B	1-443	PDB
6R7N	EM	650 A	B	1-443	PDB
8H38	EM	425 A	B	1-443	PDB
8H3A	EM	751 A	B	1-443	PDB
8H3F	EM	673 A	B	1-443	PDB
AF-P61201-F1	Predicted				AlphaFoldDB

126 variants for P61201

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs755145333 CA392454274	4	M>L		No	ClinGen ExAC gnomAD
rs536586238 CA7551069	4	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA7551070 rs755145333	4	M>V		No	ClinGen ExAC gnomAD
rs757080604 CA7551067	9	M>L		No	ClinGen ExAC gnomAD
CA392454158 rs1268578320	12	D>E		No	ClinGen TOPMed
rs1566888918	14	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs763856167 CA7551065	15	D>E		No	ClinGen ExAC
rs1243867053 CA392454118	15	D>V		No	ClinGen gnomAD
TCGA novel	16	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7551064 rs755900606	17	D>N		No	ClinGen ExAC gnomAD
rs1208008862 CA392453019	28	P>A		No	ClinGen TOPMed
CA392453015 rs1340643217	28	P>R		No	ClinGen gnomAD
rs751093881 CA7551041	31	D>N		No	ClinGen ExAC gnomAD
TCGA novel	36	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765862293 CA7551040	41	A>T		No	ClinGen ExAC gnomAD
rs1488295405 CA392452801	45	D>E		No	ClinGen TOPMed
CA392452781 rs1225323673	47	P>A		No	ClinGen gnomAD
TCGA novel	49	A>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7551038 rs368659951	49	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	50	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1442543054 CA392452711	52	S>N		No	ClinGen gnomAD
CA392452684 rs1322055026	53	S>N		No	ClinGen gnomAD
CA270190808 rs868430080	68	G>*		No	ClinGen Ensembl
CA7551014 rs754387847	75	M>I		No	ClinGen ExAC gnomAD
rs1241730917 CA392452480	79	N>T		No	ClinGen gnomAD
rs111854025 CA270190790	80	F>L		No	ClinGen Ensembl
CA392451689 rs1292541283	83	T>A		No	ClinGen TOPMed gnomAD
rs1012786288 CA270187170	83	T>K		No	ClinGen TOPMed
CA392451599 rs1271315556	90	N>S		No	ClinGen gnomAD
COSM555294 rs1433446000 CA392451589	91	R>T	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1391201034 CA392451474	100	R>Q		No	ClinGen TOPMed
CA7550998 rs745372669	100	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1428898469 CA392451462	101	S>T		No	ClinGen TOPMed
CA392451455 rs1168726113	102	A>S		No	ClinGen gnomAD
TCGA novel	108	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	110	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs961534479 CA270187067	112	I>V		No	ClinGen Ensembl
TCGA novel	116	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	117	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392451280 rs1268138380	118	Y>C		No	ClinGen TOPMed
CA392451253 rs1361040987	120	S>C		No	ClinGen TOPMed
CA392451233 rs1418483204	122	S>F		No	ClinGen gnomAD
rs1162777362 CA392450918	125	M>K		No	ClinGen gnomAD
CA392450846 rs1566883521	135	T>S		No	ClinGen Ensembl
CA392450780 rs1480090014	144	N>S		No	ClinGen gnomAD
CA392450719 rs1207048242	152	N>K		No	ClinGen gnomAD
CA270185010 rs907944247	159	Y>C		No	ClinGen TOPMed gnomAD
CA392450663 rs1317524775	159	Y>H		No	ClinGen gnomAD
CA392450649 rs1302271098	161	E>Q		No	ClinGen gnomAD
rs376675090 CA7550954	162	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA270184996 rs376675090	162	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	171	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1345232593 CA392450578	171	I>V		No	ClinGen gnomAD
CA7550952 rs769174765	173	R>C		No	ClinGen ExAC gnomAD
CA392450541 rs1429106377	176	H>R		No	ClinGen TOPMed gnomAD
TCGA novel	176	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1360968547 CA392450531	177	Q>H		No	ClinGen TOPMed
TCGA novel	179	C>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7550930 rs762726219	189	K>R		No	ClinGen ExAC gnomAD
TCGA novel	191	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	191	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	192	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	207	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA270182301 rs996466507	209	K>R		No	ClinGen TOPMed
TCGA novel	211	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	211	N>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392449889 rs1167693947	216	A>G		No	ClinGen gnomAD
rs1566882707 CA392449884	217	L>V		No	ClinGen Ensembl
rs1291943803 CA392449496	250	E>Q		No	ClinGen gnomAD
TCGA novel	254	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	259	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	260	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1278623390 CA392449395	263	K>R		No	ClinGen gnomAD
TCGA novel	265	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749399929 CA7550899	274	T>S		No	ClinGen ExAC gnomAD
CA392449315 rs1384326741	275	T>A		No	ClinGen TOPMed
TCGA novel	279	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	286	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs78807047 CA270181866	290	G>E		No	ClinGen Ensembl
TCGA novel	297	Q>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758646732 CA270181700	300	K>R		No	ClinGen Ensembl
CA392449087 rs1307746794	305	D>N		No	ClinGen TOPMed
rs758202372 CA7550874 COSM701132	307	E>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs750242581 CA7550873	311	M>V		No	ClinGen ExAC TOPMed gnomAD
rs757068018 CA7550871	315	V>I		No	ClinGen ExAC gnomAD
rs1357436726 CA392448804	318	Y>H		No	ClinGen gnomAD
rs1314432566 CA392448786	319	Q>P		No	ClinGen gnomAD
rs748242784 CA7550858	320	N>S		No	ClinGen ExAC gnomAD
TCGA novel	325	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	328	K>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439764650 CA392448695	329	I>F		No	ClinGen gnomAD
rs1263479924 CA392448643	336	N>S		No	ClinGen TOPMed gnomAD
TCGA novel	338	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA270178726 rs941161855	339	D>G		No	ClinGen Ensembl
rs866807621 CA270177686	350	L>I		No	ClinGen Ensembl
CA270177676 rs959577363	352	R>Q		No	ClinGen gnomAD
CA392448226 rs1420030674	360	I>V		No	ClinGen TOPMed
TCGA novel	363	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA270177641 rs1802452	367	T>S		No	ClinGen Ensembl
TCGA novel	369	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773645165 CA7550842	372	P>L		No	ClinGen ExAC gnomAD
TCGA novel	380	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	380	I>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1431531000 CA392447879	381	D>E		No	ClinGen TOPMed
rs1311699082 CA392447642	396	N>K		No	ClinGen TOPMed
rs747929203 CA7550810	397	T>A		No	ClinGen ExAC TOPMed gnomAD
rs754590801 CA7550808	398	I>V		No	ClinGen ExAC gnomAD
TCGA novel	401	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	401	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746513462 CA7550807	405	V>L		No	ClinGen ExAC gnomAD
CA7550805 rs370391204	410	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1283495283 CA392447461	413	H>D		No	ClinGen TOPMed
rs201832558 CA270176329	414	Q>E		No	ClinGen Ensembl
rs765813477 CA7550803	416	R>G		No	ClinGen ExAC gnomAD
rs1306438790 CA392447398	419	A>E		No	ClinGen TOPMed gnomAD
rs1369277510 CA392447402	419	A>S		No	ClinGen gnomAD
CA270176319 rs377183837	420	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs377183837 CA7550801	420	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1204426065 CA392447368	423	A>T		No	ClinGen gnomAD
rs1219622231 CA392447296	428	T>A		No	ClinGen gnomAD
rs1271812497 CA392447273	430	Q>E		No	ClinGen gnomAD
CA392447260 rs1284446087	431	L>V		No	ClinGen gnomAD
rs767625268 CA7550797	432	N>S		No	ClinGen ExAC gnomAD
rs143666055 CA7550796	434	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs773157842 CA7550795	435	N>S		No	ClinGen ExAC TOPMed gnomAD
CA7550794 rs769677428	439	V>D		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P61201

1 regional properties for P61201

Type	Name	Position	InterPro Accession
domain	Proteasome component (PCI) domain	254 - 427	IPR000717

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
COP9 signalosome	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

12 GO annotations of biological process

Name	Definition
inner cell mass cell proliferation	The proliferation of cells in the inner cell mass.
negative regulation of nucleic acid-templated transcription	Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron.
protein deneddylation	The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein neddylation	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of protein neddylation	Any process that modulates the frequency, rate or extent of protein neddylation.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
skeletal muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
trophectodermal cell proliferation	The proliferation of cells in the trophectoderm.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P61202	Cops2	COP9 signalosome complex subunit 2	Mus musculus (Mouse)	PR
P61203	Cops2	COP9 signalosome complex subunit 2	Rattus norvegicus (Rat)	PR
O01422	csn-2	COP9 signalosome complex subunit 2	Caenorhabditis elegans	PR
Q6IQT4	cops2	COP9 signalosome complex subunit 2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSDMEDDFMC	DDEEDYDLEY	SEDSNSEPNV	DLENQYYNSK	ALKEDDPKAA	LSSFQKVLEL
70	80	90	100	110	120
EGEKGEWGFK	ALKQMIKINF	KLTNFPEMMN	RYKQLLTYIR	SAVTRNYSEK	SINSILDYIS
130	140	150	160	170	180
TSKQMDLLQE	FYETTLEALK	DAKNDRLWFK	TNTKLGKLYL	EREEYGKLQK	ILRQLHQSCQ
190	200	210	220	230	240
TDDGEDDLKK	GTQLLEIYAL	EIQMYTAQKN	NKKLKALYEQ	SLHIKSAIPH	PLIMGVIREC
250	260	270	280	290	300
GGKMHLREGE	FEKAHTDFFE	AFKNYDESGS	PRRTTCLKYL	VLANMLMKSG	INPFDSQEAK
310	320	330	340	350	360
PYKNDPEILA	MTNLVSAYQN	NDITEFEKIL	KTNHSNIMDD	PFIREHIEEL	LRNIRTQVLI
370	380	390	400	410	420
KLIKPYTRIH	IPFISKELNI	DVADVESLLV	QCILDNTIHG	RIDQVNQLLE	LDHQKRGGAR
430	440
YTALDKWTNQ	LNSLNQAVVS	KLA