O01422

PR
Gene name
csn-2 (B0025.2)
Protein name
COP9 signalosome complex subunit 2
Names
Signalosome subunit 2
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_B0025.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

397-484 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O01422

Entry ID Method Resolution Chain Position Source
AF-O01422-F1 Predicted AlphaFoldDB

No variants for O01422

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O01422

No associated diseases with O01422

1 regional properties for O01422

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 254 - 426 IPR000717

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
cell cycle switching The process in which a cell switches cell cycle mode.
negative regulation of ubiquitin protein ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
regulation of oogenesis Any process that modulates the frequency, rate or extent of oogenesis.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P61201 COPS2 COP9 signalosome complex subunit 2 Homo sapiens (Human) PR
P61202 Cops2 COP9 signalosome complex subunit 2 Mus musculus (Mouse) PR
P61203 Cops2 COP9 signalosome complex subunit 2 Rattus norvegicus (Rat) PR
Q6IQT4 cops2 COP9 signalosome complex subunit 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MGDEYMDDDE DYGFEYEDDS GSEPDVDMEN QYYTAKGLRS DGKLDEAIKS FEKVLELEGE
70 80 90 100 110 120
KGEWGFKALK QMIKITFGQN RLEKMLEYYR QLLTYIKSAV TKNYSEKSIN AILDYISTSR
130 140 150 160 170 180
QMDLLQHFYE TTLDALKDAK NERLWFKTNT KLGKLFFDLH EFTKLEKIVK QLKVSCKNEQ
190 200 210 220 230 240
GEEDQRKGTQ LLEIYALEIQ MYTEQKNNKA LKWVYELATQ AIHTKSAIPH PLILGTIREC
250 260 270 280 290 300
GGKMHLRDGR FLDAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLIKSD INPFDSQEAK
310 320 330 340 350 360
PFKNEPEIVA MTQMVQAYQD NDIQAFEQIM AAHQDSIMAD PFIREHTEEL MNNIRTQVLL
370 380 390 400 410 420
RLIRPYTNVR ISYLSQKLKV SQKEVIHLLV DAILDDGLEA KINEESGMIE MPKNKKKMMV
430 440 450 460 470 480
TSLVVPNAGD QGTTKSDSKP GTSSEPSTTT SVTSSILQGP PATSSCHQEL SMDGLRVWAE
490
RIDSIQSNIG TRIKF