AiPD: Autoinhibited Protein Database

P61011

Gene name	SRP54
Protein name	Signal recognition particle 54 kDa protein
Names	SRP54
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6729
EC number	3.6.5.4: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-49 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

10 structures for P61011

Entry ID	Method	Resolution	Chain	Position	Source
1MFQ	X-ray	310 A	C	323-441	PDB
1QB2	X-ray	210 A	A/B	326-434	PDB
5L3Q	X-ray	320 A	A/C	1-436	PDB
6Y2Z	X-ray	215 A	A/B	1-296	PDB
6Y30	X-ray	265 A	A/B	1-296	PDB
6Y31	X-ray	400 A	A/B/C/D	1-296	PDB
6Y32	X-ray	260 A	A/C/E/G	1-296	PDB
7NFX	EM	320 A	x	1-504	PDB
7QWQ	EM	283 A	x	1-504	PDB
AF-P61011-F1	Predicted				AlphaFoldDB

203 variants for P61011

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001266771 TCGA novel rs2044272867	111	G>R	Variant assessed as Somatic; impact. Inborn genetic diseases [NCI-TCGA, ClinVar]	Yes	ClinVar NCI-TCGA dbSNP
rs1594996301 RCV003117679 VAR_083566 RCV000999507 CA389439272	113	G>R	Neutropenia, severe congenital, 8, autosomal dominant SCN8 [ClinVar, UniProt]	Yes	ClinGen ClinVar Ensembl dbSNP UniProt
RCV000999505 CA389439347 VAR_083567 RCV000577889 rs1555354200	115	T>A	Neutropenia, severe congenital, 8, autosomal dominant Shwachman-Diamond syndrome 1 SCN8; decreases expression levels; decreases GTPase activity; decreases neutrophil numbers and migration capacity [ClinVar, UniProt]	Yes	ClinGen ClinVar Ensembl dbSNP UniProt
RCV000731602 rs1555354198 RCV000999506 RCV000577900	117	T>missing	Neutropenia, severe congenital, 8, autosomal dominant Shwachman-Diamond syndrome 1 [ClinVar]	Yes	ClinVar dbSNP
VAR_083568	117	T>del	SCN8; decreases expression levels; slightly decreases GTPase activity; decreases neutrophil numbers and migration capacity; decreased granulocyte proliferation; delayed granulocytic differentiation; impaired signaling; increased apoptosis; induced autophagy [UniProt]	Yes	UniProt
VAR_083569	118	C>Y	SCN8; decreased granulocyte proliferation; increased apoptosis [UniProt]	Yes	UniProt
VAR_083570	136	C>Y	SCN8; decreased granulocyte proliferation; delayed granulocytic differentiation; impaired signaling; induced autophagy [UniProt]	Yes	UniProt
rs1595004126 RCV000999508 CA389442992 VAR_083571	223	A>D	Neutropenia, severe congenital, 8, autosomal dominant SCN8; decreased granulocyte proliferation; induced autophagy [ClinVar, UniProt]	Yes	ClinGen ClinVar Ensembl dbSNP UniProt
rs1555354750 RCV000999504 RCV000577921 CA389443030 RCV001266476 VAR_083572	226	G>E	Neutropenia, severe congenital, 8, autosomal dominant Inborn genetic diseases Shwachman-Diamond syndrome 1 SCN8; decreases expression levels; decreases neutrophil numbers and migration capacity; faster dissociation of the interaction with the SRP receptor subunit SRPRA; reduced SR compaction; impaired interaction with SR; impaired detachment from ribosome; effects on enzymatic activity are unclear as both normal and reduced GTPase activity have been reported [ClinVar, UniProt]	Yes	ClinGen ClinVar Ensembl dbSNP UniProt
VAR_083573 rs1595004676 RCV000999509 CA389444509	274	G>D	Neutropenia, severe congenital, 8, autosomal dominant SCN8 [ClinVar, UniProt]	Yes	ClinGen ClinVar Ensembl dbSNP UniProt
CA7153465 rs777914961	5	D>G		No	ClinGen ExAC gnomAD
CA7153467 rs771241246	8	R>I		No	ClinGen ExAC
rs774740121 CA7153468	8	R>S		No	ClinGen ExAC gnomAD
TCGA novel	9	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389435913 rs1566644417	12	S>L		No	ClinGen Ensembl
rs760145596 CA7153469	15	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7153471 rs775147862	16	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1321068162 CA389435950	18	S>N		No	ClinGen TOPMed
rs1204970328 CA389435961	19	N>D		No	ClinGen gnomAD
CA7153474 rs753470590	20	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7153476 rs373410464	22	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373410464 CA389436024	22	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA389436055 rs1566644458	23	I>M		No	ClinGen Ensembl
rs141757944 CA7153477	26	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7153501 rs766140384	28	L>S		No	ClinGen ExAC gnomAD
rs1289604177 CA389436447	30	A>T		No	ClinGen gnomAD
rs1411095348 CA389436460	31	M>I		No	ClinGen TOPMed
rs1211048627 CA389436493	36	C>F		No	ClinGen gnomAD
rs1464008157 CA389436529	40	L>V		No	ClinGen gnomAD
rs1210421994 CA389436608	45	N>S		No	ClinGen gnomAD
TCGA novel	47	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389436806 rs1264306584	55	N>S		No	ClinGen TOPMed
CA389436815 rs1471592825	56	V>I		No	ClinGen gnomAD
rs774086068 CA7153521	59	A>V		No	ClinGen ExAC gnomAD
CA258809251 rs968541224	60	I>V		No	ClinGen TOPMed
CA389437202 rs1306533257	67	S>C		No	ClinGen gnomAD
CA389437205 rs1306533257	67	S>F		No	ClinGen gnomAD
rs1234597472 CA389437309	73	K>R		No	ClinGen gnomAD
rs767426097 CA7153523	74	M>I		No	ClinGen ExAC gnomAD
CA389437954 rs1342198371	78	A>T		No	ClinGen gnomAD
CA389437994 rs1233154100	83	L>H		No	ClinGen gnomAD
TCGA novel	84	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389438002 rs1274959716	85	K>E		No	ClinGen gnomAD
rs1458774069 CA389438626	86	L>I		No	ClinGen gnomAD
CA389438685 rs1594996149	89	P>S		No	ClinGen Ensembl
rs775533482 CA7153545	92	K>E		No	ClinGen ExAC
rs760646389 CA7153546	95	T>A		No	ClinGen ExAC gnomAD
rs765427111 CA7153547	95	T>I		No	ClinGen ExAC gnomAD
rs1366664904 CA389438869	97	T>I		No	ClinGen TOPMed gnomAD
rs750470973 CA7153549	100	K>E		No	ClinGen ExAC TOPMed gnomAD
CA389439044 rs1452571935	104	I>M		No	ClinGen TOPMed
rs1340667190 CA389439064	105	M>I		No	ClinGen TOPMed gnomAD
rs374057335 CA389439105	106	F>L		No	ClinGen ESP ExAC gnomAD
CA258813973 rs868802635	112	S>I		No	ClinGen Ensembl
rs753280830 CA7153555	119	S>A		No	ClinGen ExAC gnomAD
rs368641782 CA258815034	122	A>T		No	ClinGen ESP TOPMed
CA389439693 rs1235733928	123	Y>C		No	ClinGen gnomAD
rs1278502913 CA389439701	124	Y>C		No	ClinGen gnomAD
CA7153588 rs191230389	125	Y>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767571482 CA7153589	127	R>K		No	ClinGen ExAC gnomAD
rs1254411395 CA389439730	128	K>R		No	ClinGen gnomAD
CA389439734 rs1270020128	129	G>S		No	ClinGen TOPMed gnomAD
rs1177075638 CA389439771	133	C>Y		No	ClinGen gnomAD
rs761089126 CA7153591	137	A>S		No	ClinGen ExAC gnomAD
TCGA novel	143	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775741587 CA7153609	143	G>A		No	ClinGen ExAC gnomAD
COSM1515532 CA7153611 rs764460322	153	T>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	163	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389441047 rs1232030221	171	I>V		No	ClinGen gnomAD
rs1595001825 CA389441086	174	E>G		No	ClinGen Ensembl
CA389441101 RCV000761872 rs1566651484	175	G>E		No	ClinGen ClinVar Ensembl dbSNP
CA7153633 rs201104736	177	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	178	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389441204 rs1243071157	179	F>L		No	ClinGen TOPMed
CA389441273 rs1595001858	182	E>K		No	ClinGen Ensembl
TCGA novel	186	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA258817332 rs1011890852	186	I>V		No	ClinGen TOPMed
CA7153634 rs763467987	187	I>L		No	ClinGen ExAC gnomAD
CA258817357 rs1021985705	187	I>T		No	ClinGen TOPMed
TCGA novel	188	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1229763852 CA389441391	188	I>V		No	ClinGen gnomAD
rs1595001893 CA389441467	193	G>A		No	ClinGen Ensembl
rs1429576232 CA389441488	195	H>N		No	ClinGen TOPMed
rs766018104 CA7153635	198	E>G		No	ClinGen ExAC
CA7153636 rs369651041	204	E>V		No	ClinGen ESP ExAC gnomAD
rs374247114 CA258817390	210	N>S		No	ClinGen ESP TOPMed
rs140228686 CA7153639	212	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs759274453 CA7153637	212	I>V		No	ClinGen ExAC gnomAD
rs774984145 CA7153654	213	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	216	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7153658 rs760322837	217	I>T		No	ClinGen ExAC gnomAD
rs748554500 CA7153657	217	I>V		No	ClinGen ExAC gnomAD
COSM1748821 CA389442951 rs1395833761	221	M>V	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1400579593 CA389442984	223	A>T		No	ClinGen TOPMed
TCGA novel	224	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757036271 CA7153661	225	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	234	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1397184907 CA389443236	235	A>S		No	ClinGen gnomAD
rs1299865835 CA389443331	238	D>E		No	ClinGen TOPMed
CA258818843 rs993281121	240	V>A		No	ClinGen Ensembl
CA389443367 rs1433091586	240	V>I		No	ClinGen gnomAD
CA389443393 rs1173414306	241	D>E		No	ClinGen gnomAD
CA258818846 rs975664879	246	I>V		No	ClinGen TOPMed
rs1282073104 CA389443667	253	H>R		No	ClinGen TOPMed gnomAD
CA258818860 rs920906296	259	A>T		No	ClinGen TOPMed
rs750331626 CA7153663	260	L>V		No	ClinGen ExAC gnomAD
rs755101156 CA7153664	261	S>T		No	ClinGen ExAC gnomAD
CA7153686 rs756132942	264	A>S		No	ClinGen ExAC gnomAD
CA258819192 rs756132942 COSM3419784	264	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs778122134 CA7153687	266	T>A		No	ClinGen ExAC gnomAD
TCGA novel	268	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7153688 rs749487051	269	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1262755314 CA389444313	269	P>S		No	ClinGen gnomAD
rs1372808777 CA389444397	271	I>V		No	ClinGen gnomAD
rs746403621 CA389444466	273	I>F		No	ClinGen ExAC gnomAD
rs746403621 CA7153691	273	I>V		No	ClinGen ExAC gnomAD
rs746599961 CA7153694	278	H>R		No	ClinGen ExAC gnomAD
rs768022021 CA389444584	279	I>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	279	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7153696 rs776316751	279	I>T		No	ClinGen ExAC gnomAD
rs768022021 CA7153695	279	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	287	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7153697 rs761407366	288	Q>E		No	ClinGen ExAC gnomAD
CA7153698 rs150290957	293	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1236932073 CA389445116	297	M>V		No	ClinGen gnomAD
TCGA novel	298	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	299	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389445207 rs1375522228	302	G>E		No	ClinGen TOPMed gnomAD
rs1240561251 CA389445255	305	D>G		No	ClinGen gnomAD
CA389445479 rs1290822406	314	D>E		No	ClinGen TOPMed gnomAD
rs1252091441 CA389445502	315	N>S		No	ClinGen gnomAD
COSM955483 CA7153724 rs764261072 RCV001327214	317	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
CA389445559 rs1180440839	318	L>F		No	ClinGen gnomAD
CA7153725 rs753898314	324	H>Q		No	ClinGen ExAC gnomAD
rs755358034 CA7153759	325	G>D		No	ClinGen ExAC gnomAD
CA389446912 rs1273302039	332	M>T		No	ClinGen gnomAD
rs755668892 CA7153762	336	F>L		No	ClinGen ExAC
CA258822904 rs957100298	342	M>I		No	ClinGen TOPMed gnomAD
CA389447138 rs1485986942	347	Q>E		No	ClinGen gnomAD
TCGA novel	352	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1408854882	355	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326323536 CA389447361	360	M>V		No	ClinGen gnomAD
rs998553668 CA258823090	361	S>N		No	ClinGen TOPMed gnomAD
TCGA novel	365	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759934065 CA7153777	366	Q>R		No	ClinGen ExAC gnomAD
CA7153778 rs767844326	368	S>*		No	ClinGen ExAC gnomAD
rs753224082 CA7153779	369	M>V		No	ClinGen ExAC gnomAD
rs1162883929 CA389447551 COSM168602	373	K>N	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1356180792 CA389447577	375	L>S		No	ClinGen gnomAD
CA389447651 rs1401533917	380	D>G		No	ClinGen gnomAD
rs1343631939 CA389447690	385	Q>E		No	ClinGen gnomAD
CA389447692 rs1399844182	385	Q>R		No	ClinGen gnomAD
CA258823100 rs1051117182	386	E>K		No	ClinGen Ensembl
rs1439485748 CA389447945	387	L>V		No	ClinGen gnomAD
rs144152355 CA7153800	390	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA389448046 rs1397088670	391	D>G		No	ClinGen TOPMed gnomAD
CA258825082 rs868172859	393	A>T		No	ClinGen TOPMed
rs1172350748 COSM1607643 CA389448116	394	K>R	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs758058844 CA7153804	395	V>G		No	ClinGen ExAC gnomAD
rs199746329 CA258825088	400	P>A		No	ClinGen 1000Genomes
rs1398862907 CA389448318	404	Q>E		No	ClinGen TOPMed gnomAD
rs370656783 CA7153806	406	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1199749218 CA389448392	408	R>G		No	ClinGen gnomAD
rs532831292 CA7153807	410	S>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1466369729 CA389448458	412	V>I		No	ClinGen TOPMed
CA7153809 rs748095811	414	T>P		No	ClinGen ExAC gnomAD
CA389448513 rs1341399630	415	R>S		No	ClinGen gnomAD
CA389448523 rs770936481	416	D>N		No	ClinGen ExAC gnomAD
CA7153810 rs770936481	416	D>Y		No	ClinGen ExAC gnomAD
CA7153811 rs374841884	417	V>I		No	ClinGen ESP ExAC gnomAD
TCGA novel	424	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	425	T>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389448703 rs1443152835	426	K>N		No	ClinGen TOPMed gnomAD
CA7153813 rs772221729	428	A>S		No	ClinGen ExAC gnomAD
TCGA novel	434	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	445	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389449231 COSM1748822 rs1285684867	445	D>N	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA389449240 rs1268646280	446	M>V		No	ClinGen gnomAD
rs1181892852 CA389449297	453	S>L		No	ClinGen gnomAD
rs112080225 CA258827952	455	M>I		No	ClinGen Ensembl
TCGA novel	461	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389449377 rs1375783172	464	K>R		No	ClinGen gnomAD
TCGA novel	465	M>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA389449460 rs1317718089	475	G>R		No	ClinGen TOPMed
CA258828539 rs868421346	478	A>V		No	ClinGen Ensembl
rs1330987192 CA389449496	479	G>R		No	ClinGen gnomAD
rs1237050599 CA389449513	481	Q>H		No	ClinGen gnomAD
CA258828541 rs1017147449	481	Q>R		No	ClinGen TOPMed
CA389449555 rs1595021550	487	F>V		No	ClinGen Ensembl
CA258828543 rs77182768	488	Q>*		No	ClinGen Ensembl
rs1566659197 CA389449585	491	A>T		No	ClinGen Ensembl
rs963308198 CA258828546	492	A>S		No	ClinGen TOPMed
CA389449606 rs1312140320	494	N>K		No	ClinGen gnomAD
rs751720012 CA7153883	495	M>I		No	ClinGen ExAC gnomAD
CA7153881 rs757124156	495	M>L		No	ClinGen ExAC TOPMed gnomAD
rs766463902 CA7153882	495	M>T		No	ClinGen ExAC gnomAD
CA389449609 rs757124156	495	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1253304288 CA389449626	497	G>A		No	ClinGen gnomAD
CA389449633 rs1469477813	498	M>K		No	ClinGen gnomAD
CA389449641 rs1189261921	499	M>T		No	ClinGen gnomAD
CA389449673 rs1190490251	503	N>K		No	ClinGen TOPMed gnomAD
CA7153884 rs755009516	503	N>T		No	ClinGen ExAC TOPMed gnomAD
rs781520127 CA7153885	504	M>V		No	ClinGen ExAC gnomAD

1 associated diseases with P61011

[MIM: 618752]: Neutropenia, severe congenital 8, autosomal dominant (SCN8)

A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. {ECO:0000269|PubMed:28972538, ECO:0000269|PubMed:29914977, ECO:0000269|PubMed:34020957}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A form of severe congenital neutropenia, a disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. {ECO:0000269|PubMed:28972538, ECO:0000269|PubMed:29914977, ECO:0000269|PubMed:34020957}. Note=The disease is caused by variants affecting the gene represented in this entry.

3 regional properties for P61011

Type	Name	Position	InterPro Accession
conserved_site	Serpin, conserved site	435 - 445	IPR023795
domain	Serpin domain	87 - 462	IPR023796
domain	Antithrombin-III, serpin domain	71 - 464	IPR033829

Functions

		Description
EC Number	3.6.5.4	Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus speckle Cytoplasm Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
signal recognition particle, endoplasmic reticulum targeting	A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.

7 GO annotations of molecular function

Name	Definition
7S RNA binding	Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
endoplasmic reticulum signal peptide binding	Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.
GDP binding	Binding to GDP, guanosine 5'-diphosphate.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
ribonucleoprotein complex binding	Binding to a complex of RNA and protein.
RNA binding	Binding to an RNA molecule or a portion thereof.

7 GO annotations of biological process

Name	Definition
exocrine pancreas development	The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
granulocyte differentiation	The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
protein targeting to ER	The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.
SRP-dependent cotranslational protein targeting to membrane	The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting.
SRP-dependent cotranslational protein targeting to membrane, translocation	The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P20424	SRP54	Signal recognition particle subunit SRP54	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q2T9U1	SRP54	Signal recognition particle 54 kDa protein	Bos taurus (Bovine)	PR
P61010	SRP54	Signal recognition particle 54 kDa protein	Canis lupus familiaris (Dog) (Canis familiaris)	PR
P14576	Srp54	Signal recognition particle 54 kDa protein	Mus musculus (Mouse)	PR
Q6AYB5	Srp54	Signal recognition particle 54 kDa protein	Rattus norvegicus (Rat)	PR
P37107	FFC	Signal recognition particle 54 kDa protein, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR
P49966	SRP-54B	Signal recognition particle 54 kDa protein 2	Arabidopsis thaliana (Mouse-ear cress)	PR
P49972		Signal recognition particle 54 kDa protein 2	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	PR
P49971		Signal recognition particle 54 kDa protein 1	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	PR

10	20	30	40	50	60
MVLADLGRKI	TSALRSLSNA	TIINEEVLNA	MLKEVCTALL	EADVNIKLVK	QLRENVKSAI
70	80	90	100	110	120
DLEEMASGLN	KRKMIQHAVF	KELVKLVDPG	VKAWTPTKGK	QNVIMFVGLQ	GSGKTTTCSK
130	140	150	160	170	180
LAYYYQRKGW	KTCLICADTF	RAGAFDQLKQ	NATKARIPFY	GSYTEMDPVI	IASEGVEKFK
190	200	210	220	230	240
NENFEIIIVD	TSGRHKQEDS	LFEEMLQVAN	AIQPDNIVYV	MDASIGQACE	AQAKAFKDKV
250	260	270	280	290	300
DVASVIVTKL	DGHAKGGGAL	SAVAATKSPI	IFIGTGEHID	DFEPFKTQPF	ISKLLGMGDI
310	320	330	340	350	360
EGLIDKVNEL	KLDDNEALIE	KLKHGQFTLR	DMYEQFQNIM	KMGPFSQILG	MIPGFGTDFM
370	380	390	400	410	420
SKGNEQESMA	RLKKLMTIMD	SMNDQELDST	DGAKVFSKQP	GRIQRVARGS	GVSTRDVQEL
430	440	450	460	470	480
LTQYTKFAQM	VKKMGGIKGL	FKGGDMSKNV	SQSQMAKLNQ	QMAKMMDPRV	LHHMGGMAGL
490	500
QSMMRQFQQG	AAGNMKGMMG	FNNM