P37107
PR
Gene name |
FFC (CPSRP54, At5g03940, F8F6_150) |
Protein name |
Signal recognition particle 54 kDa protein, chloroplastic |
Names |
54 chloroplast protein, 54CP, SRP54, cpSRP54, FFC |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G03940 |
EC number |
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P37107
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2HUG | NMR | - | B | 530-543 | PDB |
| 3UI2 | X-ray | 318 A | B | 528-540 | PDB |
| 5L3R | X-ray | 250 A | A/C | 77-371 | PDB |
| AF-P37107-F1 | Predicted | AlphaFoldDB |
20 variants for P37107
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_1063241_A_T | 6 | F>Y | No | 1000Genomes | |
| tmp_5_1063182_C_G,T | 26 | A>P | No | 1000Genomes | |
| tmp_5_1063182_C_G,T | 26 | A>T | No | 1000Genomes | |
| tmp_5_1063169_G_A | 30 | S>F | No | 1000Genomes | |
| ENSVATH10550552 | 36 | T>A | No | 1000Genomes | |
| ENSVATH06918677 | 60 | K>Q | No | 1000Genomes | |
| tmp_5_1062688_C_T | 97 | V>I | No | 1000Genomes | |
| ENSVATH13911814 | 125 | R>K | No | 1000Genomes | |
| tmp_5_1062514_C_T | 131 | V>I | No | 1000Genomes | |
| tmp_5_1062469_G_C | 146 | P>A | No | 1000Genomes | |
| tmp_5_1062282_T_G | 165 | E>D | No | 1000Genomes | |
| ENSVATH10550497 | 221 | D>A | No | 1000Genomes | |
| ENSVATH10550495 | 278 | D>G | No | 1000Genomes | |
| ENSVATH03018896 | 290 | T>I | No | 1000Genomes | |
| ENSVATH06918662 | 391 | A>V | No | 1000Genomes | |
| ENSVATH00605413 | 452 | M>I | No | 1000Genomes | |
| ENSVATH03018892 | 482 | G>A | No | 1000Genomes | |
| tmp_5_1060305_G_A | 552 | S>L | No | 1000Genomes | |
| ENSVATH06918654 | 554 | K>N | No | 1000Genomes | |
| ENSVATH06918653 | 555 | P>S | No | 1000Genomes |
No associated diseases with P37107
4 regional properties for P37107
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Signal recognition particle, SRP54 subunit, GTPase domain | 176 - 371 | IPR000897 |
| domain | AAA+ ATPase domain | 175 - 322 | IPR003593 |
| domain | Signal recognition particle, SRP54 subunit, M-domain | 402 - 500 | IPR004125 |
| domain | Signal recognition particle SRP54, helical bundle | 77 - 162 | IPR013822 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.4 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| chloroplast stroma | The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| signal recognition particle, endoplasmic reticulum targeting | A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7S RNA binding | Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| protein domain specific binding | Binding to a specific domain of a protein. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein heterotrimerization | The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. |
| SRP-dependent cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2T9U1 | SRP54 | Signal recognition particle 54 kDa protein | Bos taurus (Bovine) | PR |
| P61010 | SRP54 | Signal recognition particle 54 kDa protein | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P61011 | SRP54 | Signal recognition particle 54 kDa protein | Homo sapiens (Human) | PR |
| P14576 | Srp54 | Signal recognition particle 54 kDa protein | Mus musculus (Mouse) | PR |
| Q6AYB5 | Srp54 | Signal recognition particle 54 kDa protein | Rattus norvegicus (Rat) | PR |
| P49966 | SRP-54B | Signal recognition particle 54 kDa protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P49971 | Signal recognition particle 54 kDa protein 1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR | |
| P49972 | Signal recognition particle 54 kDa protein 2 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEALQFSSVN | RVPCTLSCTG | NRRIKAAFSS | AFTGGTINSA | SLSSSRNLST | REIWSWVKSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVVGHGRYRR | SQVRAEMFGQ | LTGGLEAAWS | KLKGEEVLTK | DNIAEPMRDI | RRALLEADVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPVVRRFVQS | VSDQAVGMGV | IRGVKPDQQL | VKIVHDELVK | LMGGEVSELQ | FAKSGPTVIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAGLQGVGKT | TVCAKLACYL | KKQGKSCMLI | AGDVYRPAAI | DQLVILGEQV | GVPVYTAGTD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKPADIAKQG | LKEAKKNNVD | VVIMDTAGRL | QIDKGMMDEL | KDVKKFLNPT | EVLLVVDAMT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GQEAAALVTT | FNVEIGITGA | ILTKLDGDSR | GGAALSVKEV | SGKPIKLVGR | GERMEDLEPF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YPDRMAGRIL | GMGDVLSFVE | KATEVMRQED | AEDLQKKIMS | AKFDFNDFLK | QTRAVAKMGS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MTRVLGMIPG | MGKVSPAQIR | EAEKNLLVME | AMIEVMTPEE | RERPELLAES | PERRKRIAKD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SGKTEQQVSA | LVAQIFQMRV | KMKNLMGVME | GGSIPALSGL | EDALKAEQKA | PPGTARRKRK |
| 550 | 560 | ||||
| ADSRKKFVES | ASSKPGPRGF | GSGN |