P49972

PR
Gene name
Protein name
Signal recognition particle 54 kDa protein 2
Names
SRP54
Species
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway
sly:544156
EC number
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

319-499 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P49972

Entry ID Method Resolution Chain Position Source
AF-P49972-F1 Predicted AlphaFoldDB

150 variants for P49972

Variant ID(s) Position Change Description Diseaes Association Provenance
vcZ21TY0Y 3 L>F No Ensembl
vcZ21TY0Z 4 A>E No Ensembl
vcZ21TY10 7 G>V No Ensembl
vcZ21TY11 13 A>S No Ensembl
vcZ21TY14 19 N>K No Ensembl
vcZ21TY16 24 D>E No Ensembl
vcZ21TY19 35 I>F No Ensembl
vcZ21TY1F 39 L>V No Ensembl
vcZ21TY1G 40 L>F No Ensembl
vcZ21TY1H 40 L>P No Ensembl
vcZ21TY1I 43 D>E No Ensembl
vcZ21TY1J 45 Q>P No Ensembl
vcZ21TY1N 49 V>A No Ensembl
vcZ21TY1P 50 R>C No Ensembl
vcZ21TY1R 52 M>I No Ensembl
vcZ21TY1S 54 T>I No Ensembl
vcZ21TY1S 54 T>S No Ensembl
vcZ21TY1T 55 N>K No Ensembl
vcZ21TY1U 58 K>I No Ensembl
vcZ21TY1V 60 V>I No Ensembl
vcZ21TY1W 62 L>I No Ensembl
vcZ21TY1Z 74 I>N* No Ensembl
vcZ21TY4S 82 E>D No Ensembl
vcZ21TY4T 84 C>F No Ensembl
vcZ21TY4U 86 I>L No Ensembl
vcZ21TY4W 90 G>V No Ensembl
vcZ21TY4X 93 S>A No Ensembl
vcZ21TY50 98 K>* No Ensembl
vcZ21TY51 100 K>I No Ensembl
vcZ21TY52 100 K>N No Ensembl
vcZ21TY53 107 V>I No Ensembl
vcZ21TY5O 114 K>R No Ensembl
vcZ21TY5P 116 T>I No Ensembl
vcZ21TY5Q 119 T>P No Ensembl
vcZ21TY5R 127 K>* No Ensembl
vcZ21TY5S 129 G>A No Ensembl
vcZ21TY5T 131 K>T No Ensembl
vcZ21TY5U 134 L>F No Ensembl
vcZ21TY5V 136 C>Y No Ensembl
vcZ21TY5W 137 A>S No Ensembl
vcZ21TY5X 141 R>* No Ensembl
vcZ21TY5Y 141 R>T No Ensembl
vcZ21TY61 148 L>F No Ensembl
vcZ21TY64 157 I>T No Ensembl
vcZ21TY65 160 Y>F No Ensembl
vcZ21TY9A 173 V>I No Ensembl
vcZ21TY9B 175 G>A No Ensembl
vcZ21TY9C 178 T>A No Ensembl
vcZ21TY9C 178 T>S No Ensembl
vcZ21TY9D 179 F>Y No Ensembl
vcZ21TY9E 180 K>N No Ensembl
vcZ21TY9F 181 K>M No Ensembl
vcZ21TY9J 192 S>R No Ensembl
vcZ21TY9K 194 R>C No Ensembl
vcZ21TY9M 199 A>D No Ensembl
vcZ21TY9O 204 E>G No Ensembl
vcZ21TY9P 205 M>L No Ensembl
vcZ21TY9R 206 R>G No Ensembl
vcZ21TY9S 207 Q>L No Ensembl
vcZ21TY9T 208 V>D No Ensembl
vcZ21TY9V 212 T>A No Ensembl
vcZ21TYA8 221 M>I No Ensembl
vcZ21TYAA 222 D>V No Ensembl
vcZ21TYA9 222 D>Y No Ensembl
vcZ21TYAB 223 S>I No Ensembl
vcZ21TYAC 228 A>P No Ensembl
vcZ21TYAE 233 A>P No Ensembl
vcZ21TYAF 234 Q>P No Ensembl
vcZ21TYAG 240 V>L No Ensembl
vcZ21TYAK 260 L>I No Ensembl
vcZ21TYAM 262 A>S No Ensembl
vcZ21TYDA 264 A>G No Ensembl
vcZ21TYDC 267 K>N No Ensembl
vcZ21TYDB 267 K>Q No Ensembl
vcZ21TYDD 272 F>* No Ensembl
vcZ21TYDF 279 M>L No Ensembl
vcZ21TYDH 281 E>* No Ensembl
vcZ21TYDK 285 F>Y No Ensembl
vcZ21TYDM 288 K>E No Ensembl
vcZ21TYDO 290 F>I No Ensembl
vcZ21TYE6 297 M>V No Ensembl
vcZ21TYE7 299 D>E No Ensembl
vcZ21TYEB 306 K>* No Ensembl
vcZ21TYEC 309 E>A No Ensembl
vcZ21TYEE 312 P>L No Ensembl
vcZ21TYED 312 P>T No Ensembl
vcZ21TYEG 315 Q>H No Ensembl
vcZ21TYEF 315 Q>R No Ensembl
vcZ21TYEI 321 Q>L No Ensembl
vcZ21TYEJ 322 K>* No Ensembl
vcZ21TYEK 325 E>* No Ensembl
vcZ21TYEM 330 L>M No Ensembl
vcZ21TYER 334 Y>F No Ensembl
vcZ21TYEQ 334 Y>N No Ensembl
vcZ21TYES 337 F>L No Ensembl
vcZ21TYET 342 K>N No Ensembl
vcZ21TYEV 343 M>I No Ensembl
vcZ21TYEU 343 M>L No Ensembl
vcZ21TYEW 344 G>R No Ensembl
vcZ21TYEX 346 I>F No Ensembl
vcZ21TYEY 346 I>S No Ensembl
vcZ21TYJG 352 M>I No Ensembl
vcZ21TYJH 353 L>R No Ensembl
vcZ21TYJI 354 P>A No Ensembl
vcZ21TYJI 354 P>S No Ensembl
vcZ21TYJJ 355 G>V No Ensembl
vcZ21TYJL 357 S>C No Ensembl
vcZ21TYJN 358 A>S No Ensembl
vcZ21TYJO 361 M>K No Ensembl
vcZ21TYJR 366 E>TH No Ensembl
vcZ21TYJS 367 N>Y No Ensembl
vcZ21TYJU 372 K>R No Ensembl
vcZ21TYJV 373 I>V No Ensembl
vcZ21TYJW 374 K>* No Ensembl
vcZ21TYJX 374 K>R No Ensembl
vcZ21TYJZ 377 M>Q No Ensembl
vcZ21TYK1 380 M>L No Ensembl
vcZ21TYK2 381 D>A No Ensembl
vcZ21TYK3 383 M>R No Ensembl
vcZ21TYK5 385 N>I No Ensembl
vcZ21TYKG 387 E>D No Ensembl
vcZ21TYKH 390 S>R No Ensembl
vcZ21TYKI 392 N>Y No Ensembl
vcZ21TYKK 394 K>Q No Ensembl
vcZ21TYKM 399 S>P No Ensembl
vcZ21TYKP 402 M>I No Ensembl
vcZ21TYKR 404 I>R No Ensembl
vcZ21TYKS 405 A>S No Ensembl
vcZ21TYKW 410 R>C No Ensembl
vcZ21TYKX 411 Q>E No Ensembl
vcZ21TYL0 416 M>T No Ensembl
vcZ21TYL2 421 E>* No Ensembl
vcZ21TYL5 427 K>N No Ensembl
vcZ21TYL6 428 I>K No Ensembl
vcZ21TYL8 432 M>T No Ensembl
vcZ21TYLC 438 P>S No Ensembl
vcZ21TYLE 443 M>R No Ensembl
vcZ21TYLI 457 K>N No Ensembl
vcZ21TYLK 463 M>V No Ensembl
vcZ21TYLM 466 Q>P No Ensembl
vcZ21TYLO 468 G>D No Ensembl
vcZ21TYLP 469 G>C No Ensembl
vcZ21TYLQ 469 G>V No Ensembl
vcZ21TYLR 471 G>S No Ensembl
vcZ21TYLS 475 N>* No Ensembl
vcZ21TYLT 477 M>I No Ensembl
vcZ21TYLW 483 A>T No Ensembl
vcZ21TYLX 485 D>Y No Ensembl
vcZ21TYLZ 491 G>C No Ensembl
vcZ21TYM0 491 G>V No Ensembl

No associated diseases with P49972

4 regional properties for P49972

Type Name Position InterPro Accession
domain Signal recognition particle, SRP54 subunit, GTPase domain 101 - 296 IPR000897
domain AAA+ ATPase domain 100 - 277 IPR003593
domain Signal recognition particle, SRP54 subunit, M-domain 328 - 427 IPR004125
domain Signal recognition particle SRP54, helical bundle 2 - 87 IPR013822

Functions

Description
EC Number 3.6.5.4 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana.

4 GO annotations of molecular function

Name Definition
7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
endoplasmic reticulum signal peptide binding Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
SRP-dependent cotranslational protein targeting to membrane, translocation The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20424 SRP54 Signal recognition particle subunit SRP54 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2T9U1 SRP54 Signal recognition particle 54 kDa protein Bos taurus (Bovine) PR
P61010 SRP54 Signal recognition particle 54 kDa protein Canis lupus familiaris (Dog) (Canis familiaris) PR
P61011 SRP54 Signal recognition particle 54 kDa protein Homo sapiens (Human) PR
P14576 Srp54 Signal recognition particle 54 kDa protein Mus musculus (Mouse) PR
Q6AYB5 Srp54 Signal recognition particle 54 kDa protein Rattus norvegicus (Rat) PR
P37107 FFC Signal recognition particle 54 kDa protein, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
P49966 SRP-54B Signal recognition particle 54 kDa protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
P49971 Signal recognition particle 54 kDa protein 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MVLAELGGSI SRALQQMSNA TIIDEKVLNE CLNEITRALL QADVQFKLVR DMTTNIKKIV
70 80 90 100 110 120
NLDDLAAGHN KRRIIQQAVF NELCKILDPG KPSFTPKKGK PSIVMFVGLQ GSGKTTTCTK
130 140 150 160 170 180
YAYYHQKKGW KPALVCADTF RAGAFDQLKQ NATKAKIPFY GSYTESDPVK IAVDGVETFK
190 200 210 220 230 240
KENCDLIIVD TSGRHKQEAA LFEEMRQVAE ATKPDLVIFV MDSSIGQAAF DQAQAFKQSV
250 260 270 280 290 300
AVGAVIVTKM DGHAKGGGAL SAVAATKSPV IFIGTGEHMD EFEVFDVKPF VSRLLGMGDW
310 320 330 340 350 360
SGFMDKIHEV VPMDQQPELL QKLSEGHFTL RIMYEQFQNI LKMGPIGQVF SMLPGFSAEL
370 380 390 400 410 420
MPKGRENESQ AKIKRYMTMM DSMTNEELDS SNPKLMTDSR IMRIARGSGR QVHEVMDMME
430 440 450 460 470 480
EYKRLAKIWS KMKGLKIPKK GEMSALSRNM NAQHMSKVLP PQMLKQIGGM GGLQNLMKQM
490
GSAKDMMGGM GGMFGGGDK