P57746
Gene name |
Atp6v1d (Atp6m, Vatd) |
Protein name |
V-type proton ATPase subunit D |
Names |
V-ATPase subunit D, V-ATPase 28 kDa accessory protein, Vacuolar proton pump subunit D |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:73834 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P57746
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P57746-F1 | Predicted | AlphaFoldDB |
10 variants for P57746
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389261165 | 3 | G>C | No | EVA | |
| rs3389248710 | 31 | N>S | No | EVA | |
| rs3389177592 | 45 | R>* | No | EVA | |
| rs3389231611 | 67 | F>I | No | EVA | |
| rs3389220482 | 78 | D>N | No | EVA | |
| rs3389244044 | 118 | S>R | No | EVA | |
| rs3389238351 | 127 | G>V | No | EVA | |
| rs3403253462 | 130 | Q>L | No | EVA | |
| rs3389259064 | 170 | N>S | No | EVA | |
| rs3389231560 | 184 | L>F | No | EVA |
No associated diseases with P57746
No regional properties for P57746
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P57746 | |||
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| clathrin-coated vesicle membrane | The lipid bilayer surrounding a clathrin-coated vesicle. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. |
| vacuolar proton-transporting V-type ATPase, V1 domain | The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| protein localization to cilium | A process in which a protein is transported to, or maintained in, a location within a cilium. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32610 | VMA8 | V-type proton ATPase subunit D | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P39942 | ATP6V1D | V-type proton ATPase subunit D | Bos taurus (Bovine) | PR |
| Q9V7D2 | Vha36-1 | V-type proton ATPase subunit D 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y5K8 | ATP6V1D | V-type proton ATPase subunit D | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGKDRIEIF | PSRMAQTIMK | ARLKGAQTGR | NLLKKKSDAL | TLRFRQILKK | IIETKMLMGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VMREAAFSLA | EAKFTAGDFS | TTVIQNVNKA | QVKIRAKKDN | VAGVTLPVFE | HYHEGTDSYE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LTGLARGGEQ | LAKLKRNYAK | AVELLVELAS | LQTSFVTLDE | AIKITNRRVN | AIEHVIIPRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ERTLAYIITE | LDEREREEFY | RLKKIQEKKK | IIKEKFEKDL | ERRRAAGEVM | EPANLLAEEK |
| DEDLLFE |