P39942

PR
Gene name
ATP6V1D (ATP6M, VATD)
Protein name
V-type proton ATPase subunit D
Names
V-ATPase subunit D, V-ATPase 28 kDa accessory protein, Vacuolar proton pump subunit D
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

174-247 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P39942

Entry ID Method Resolution Chain Position Source
6XBW EM 337 A H 1-247 PDB
6XBY EM 379 A H 1-247 PDB
7KHR EM 362 A H 1-247 PDB
AF-P39942-F1 Predicted AlphaFoldDB

No variants for P39942

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P39942

No associated diseases with P39942

No regional properties for P39942

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P39942

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cell projection, cilium
  • Localizes to centrosome and the base of the cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
vacuolar proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

1 GO annotations of molecular function

Name Definition
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

4 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
pH reduction Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.
protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium.
proton transmembrane transport The directed movement of a proton across a membrane.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9V7D2 Vha36-1 V-type proton ATPase subunit D 1 Drosophila melanogaster (Fruit fly) PR
Q9Y5K8 ATP6V1D V-type proton ATPase subunit D Homo sapiens (Human) PR
P57746 Atp6v1d V-type proton ATPase subunit D Mus musculus (Mouse) PR
10 20 30 40 50 60
MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE
70 80 90 100 110 120
VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE
130 140 150 160 170 180
LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN RIEHVIIPRI
190 200 210 220 230 240
ERTLAYIITE LDEREREEFY RLKKIQEKKK ILKEKSDKDL EQRRAAGEVI EPANLLAEEK
DEDLLFE