Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P53366

Entry ID Method Resolution Chain Position Source
AF-P53366-F1 Predicted AlphaFoldDB

2 variants for P53366

Variant ID(s) Position Change Description Diseaes Association Provenance
rs81211860 44 R>T No EVA
rs693967029 182 L>I No EVA

No associated diseases with P53366

No regional properties for P53366

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P53366

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
adrenomedullin receptor binding Binding to an adrenomedullin receptor.
hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

20 GO annotations of biological process

Name Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
adrenomedullin receptor signaling pathway The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell.
amylin receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
branching involved in labyrinthine layer morphogenesis The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
G protein-coupled receptor internalization The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
negative regulation of vascular permeability Any process that reduces the extent to which blood vessels can be pervaded by fluid.
negative regulation of vasoconstriction Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction.
neural tube closure The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
positive regulation of angiogenesis Any process that activates or increases angiogenesis.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of heart rate Any process that activates or increases the frequency or rate of heart contraction.
positive regulation of vasculogenesis Any process that activates or increases the frequency, rate or extent of vasculogenesis.
regulation of systemic arterial blood pressure The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of urine volume Any process that modulates the amount of urine excreted from the body over a unit of time.
spongiotrophoblast layer development The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state.
vascular associated smooth muscle cell development The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O62827 ADM Pro-adrenomedullin Bos taurus (Bovine) PR
O77559 ADM Pro-adrenomedullin Canis lupus familiaris (Dog) (Canis familiaris) PR
P35318 ADM Pro-adrenomedullin Homo sapiens (Human) PR
10 20 30 40 50 60
MKLVPVALMY LGSLAFLGAD TARLDVAAEF RKKWNKWALS RGKRELRLSS SYPTGIADLK
70 80 90 100 110 120
AGPAQTVIRP QDVKGSSRSP QASIPDAARI RVKRYRQSMN NFQGLRSFGC RFGTCTVQKL
130 140 150 160 170 180
AHQIYQFTDK DKDGVAPRSK ISPQGYGRRR RRSLPEASLG RTLRSQEPQA HGAPASPAHQ
VLATLFRI