O62827
Gene name |
ADM |
Protein name |
Pro-adrenomedullin |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:280713 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O62827
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O62827-F1 | Predicted | AlphaFoldDB |
63 variants for O62827
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs440051673 | 4 | V>F | No | EVA | |
| rs474839049 | 4 | V>G | No | EVA | |
| rs469304366 | 6 | V>A | No | EVA | |
| rs469304366 | 6 | V>G | No | EVA | |
| rs452423659 | 7 | A>G | No | EVA | |
| rs466890471 | 10 | Y>H | No | EVA | |
| rs466890471 | 10 | Y>N | No | EVA | |
| rs446958145 | 10 | Y>S | No | EVA | |
| rs467871502 | 14 | L>P | No | EVA | |
| rs481549816 | 14 | L>V | No | EVA | |
| rs451033542 | 15 | A>P | No | EVA | |
| rs482216667 | 15 | A>V | No | EVA | |
| rs439015177 | 16 | F>L | No | EVA | |
| rs476814642 | 16 | F>S | No | EVA | |
| rs460064453 | 18 | G>A | No | EVA | |
| rs440108005 | 19 | V>G | No | EVA | |
| rs454593772 | 23 | R>L | No | EVA | |
| rs454593772 | 23 | R>P | No | EVA | |
| rs444284299 | 24 | L>P | No | EVA | |
| rs452437704 | 25 | D>E | No | EVA | |
| rs475555423 | 25 | D>H | No | EVA | |
| rs432214758 | 26 | V>E | No | EVA | |
| rs432214758 | 26 | V>G | No | EVA | |
| rs453266235 | 27 | A>G | No | EVA | |
| rs467884283 | 29 | E>G | No | EVA | |
| rs450895400 | 30 | F>V | No | EVA | |
| rs482227197 | 31 | R>G | No | EVA | |
| rs449518957 | 35 | N>S | No | EVA | |
| rs435861871 | 37 | W>C | No | EVA | |
| rs470458142 | 42 | G>R | No | EVA | |
| rs450553269 | 43 | K>R | No | EVA | |
| rs481806128 | 44 | R>G | No | EVA | |
| rs465111555 | 45 | E>* | No | EVA | |
| rs444882356 | 45 | E>D | No | EVA | |
| rs465111555 | 45 | E>Q | No | EVA | |
| rs479666776 | 46 | L>R | No | EVA | |
| rs459513417 | 47 | R>G | No | EVA | |
| rs442715948 | 49 | S>A | No | EVA | |
| rs480349116 | 51 | S>I | No | EVA | |
| rs463466752 | 52 | Y>C | No | EVA | |
| rs471603944 | 54 | T>S | No | EVA | |
| rs441265836 | 58 | D>A | No | EVA | |
| rs472800083 | 60 | K>* | No | EVA | |
| rs455947177 | 65 | Q>* | No | EVA | |
| rs435769074 | 65 | Q>L | No | EVA | |
| rs470522274 | 72 | D>Y | No | EVA | |
| rs456824817 | 75 | G>A | No | EVA | |
| rs444907249 | 76 | A>G | No | EVA | |
| rs464921245 | 76 | A>P | No | EVA | |
| rs449102732 | 83 | S>R | No | EVA | |
| rs800776138 | 108 | F>L | No | EVA | |
| rs448618704 | 117 | V>A | No | EVA | |
| rs483146359 | 120 | L>S | No | EVA | |
| rs463036469 | 122 | H>Y | No | EVA | |
| rs439872382 | 126 | H>N | No | EVA | |
| rs456787631 | 129 | D>E | No | EVA | |
| rs440650418 | 169 | P>T | No | EVA | |
| rs472244897 | 170 | K>N | No | EVA | |
| rs435140511 | 178 | R>W | No | EVA | |
| rs476157455 | 179 | V>L | No | EVA | |
| rs432973621 | 185 | T>P | No | EVA | |
| rs454017016 | 188 | I>V | No | EVA | |
| rs433844692 | 189 | I>W | No | EVA |
No associated diseases with O62827
4 regional properties for O62827
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 325 - 571 | IPR001054-1 |
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 1023 - 1241 | IPR001054-2 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 498 - 521 | IPR018297-1 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 1175 - 1198 | IPR018297-2 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| adrenomedullin receptor binding | Binding to an adrenomedullin receptor. |
| hormone activity | The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| adrenomedullin receptor signaling pathway | The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell. |
| positive regulation of heart rate | Any process that activates or increases the frequency or rate of heart contraction. |
| regulation of systemic arterial blood pressure | The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLVPVALLY | LGSLAFLGVD | TARLDVAAEF | RKKWNKWALS | RGKRELRESS | SYPTGLADVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGPVQTLIRP | QDVKGASRSP | QASSPDAARI | RVKRYRQSLN | NFQGLRSFGC | RFGTCTVQKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AHQIYHFTDK | DKDGSAPRSK | ISPQGYGRRR | RRSLPEAGLG | RTLLQPPEPK | LRGAPDSRVH |
| QVLATLRI |