AiPD: Autoinhibited Protein Database

P35318

Gene name	ADM (AM)
Protein name	Pro-adrenomedullin
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:133
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-85 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

15-85 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

9 structures for P35318

Entry ID	Method	Resolution	Chain	Position	Source
2FLY	NMR	-	A	22-41	PDB
2L7S	NMR	-	A	95-146	PDB
4RWF	X-ray	176 A	B	119-146	PDB
5V6Y	X-ray	280 A	E/F/G/H	131-146	PDB
6UUN	EM	300 A	P	95-146	PDB
6UUS	EM	240 A	P	95-146	PDB
6V2E	X-ray	183 A	B	131-146	PDB
7VV0	EM	350 A	L	30-41	PDB
AF-P35318-F1	Predicted				AlphaFoldDB

178 variants for P35318

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs766389485 CA5882259	4	V>D		No	ClinGen ExAC gnomAD
CA5882258 rs762357404	4	V>L		No	ClinGen ExAC gnomAD
CA5882260 rs148801166	6	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5882262 rs767431764	8	L>V		No	ClinGen ExAC gnomAD
rs752472370 CA5882263	9	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1289638471 CA379849987	9	M>V		No	ClinGen gnomAD
CA217928761 rs931123318	10	Y>F		No	ClinGen TOPMed gnomAD
rs1438790728 CA379850020	14	L>F		No	ClinGen gnomAD
CA5882266 rs753996172	15	A>S		No	ClinGen ExAC gnomAD
TCGA novel	15	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5882267 rs565533460	16	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1316727170 CA379850042	18	G>C		No	ClinGen gnomAD
rs1370526593 CA379850050	19	A>S		No	ClinGen TOPMed
rs746394048 CA5882269	22	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1466904863 CA379850076	23	R>Q		No	ClinGen gnomAD
rs758847030 CA5882270	23	R>W		No	ClinGen ExAC gnomAD
CA5882271 rs780403470	24	L>S		No	ClinGen ExAC gnomAD
rs1406433799 CA379850078	24	L>V		No	ClinGen TOPMed
CA379850086 rs1175444954	25	D>G		No	ClinGen gnomAD
CA5882272 rs747334853	25	D>N		No	ClinGen ExAC gnomAD
CA5882275 rs772717944	27	A>P		No	ClinGen ExAC gnomAD
rs772717944 CA379850096	27	A>S		No	ClinGen ExAC gnomAD
rs772717944 CA5882274	27	A>T		No	ClinGen ExAC gnomAD
rs1419432532 CA379850099	27	A>V		No	ClinGen gnomAD
CA217928763 rs1050560995	28	S>L		No	ClinGen TOPMed gnomAD
rs1161097911 CA379850102	28	S>T		No	ClinGen gnomAD
CA379850104 rs1050560995	28	S>W		No	ClinGen TOPMed gnomAD
rs1487313792 CA379850120	30	F>L		No	ClinGen TOPMed
rs1591387661 CA379850113	30	F>V		No	ClinGen Ensembl
rs1266925426 CA379850135	33	K>E		No	ClinGen TOPMed
CA5882296 rs368386294	35	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA5882297 rs371400834	36	K>E		No	ClinGen ESP ExAC gnomAD
TCGA novel	36	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379850177 CA5882298 rs775255772	37	W>R		No	ClinGen ExAC TOPMed gnomAD
CA379850190 rs1293506682	38	A>D		No	ClinGen gnomAD
rs374664537 CA5882300	40	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA379850205 rs1271690785	41	R>C		No	ClinGen gnomAD
rs776425868 CA5882301	43	K>N		No	ClinGen ExAC gnomAD
CA217928772 rs987918571	44	R>K		No	ClinGen TOPMed
CA379850234 rs1360261291	45	E>D		No	ClinGen TOPMed
CA5882302 rs761948640	47	R>W		No	ClinGen ExAC gnomAD
rs1258470392 CA379850260	49	S>C		No	ClinGen TOPMed gnomAD
rs5005 CA5882304 VAR_014861 RCV000959901	50	S>R		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1375373536 CA379850269	51	S>G		No	ClinGen TOPMed
TCGA novel	53	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379850294 rs1184787993	54	T>S		No	ClinGen TOPMed gnomAD
CA5882306 rs766912121	57	A>P		No	ClinGen ExAC gnomAD
CA379850312 rs1170999530	57	A>V		No	ClinGen gnomAD
CA379850319 rs1464091492	58	D>E		No	ClinGen TOPMed
rs1374226848 CA379850323	59	V>L		No	ClinGen gnomAD
rs752037871 CA5882307	60	K>N		No	ClinGen ExAC gnomAD
CA5882308 rs755466368	61	A>S		No	ClinGen ExAC gnomAD
CA217928774 rs1015030948	62	G>R		No	ClinGen Ensembl
CA379850348 rs781425252	63	P>L		No	ClinGen ExAC TOPMed gnomAD
rs781425252 CA5882309	63	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1269035117 CA379850351	64	A>S		No	ClinGen TOPMed gnomAD
rs575977037 CA5882310	65	Q>H		No	ClinGen ExAC gnomAD
rs573280699 CA5882311	66	T>A		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	66	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368598004 CA5882312	67	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA5882313 rs745407550	68	I>M		No	ClinGen ExAC TOPMed gnomAD
rs771734789 CA5882314	69	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs962132270 CA379850379	69	R>W		No	ClinGen TOPMed gnomAD
rs764500142 CA217928776	70	P>L		No	ClinGen Ensembl
rs779565271 CA5882315	70	P>S		No	ClinGen ExAC gnomAD
CA379850392 rs1486221830	71	Q>H		No	ClinGen gnomAD
CA5882316 rs746930372	72	D>V		No	ClinGen ExAC gnomAD
CA5882319 rs761587575	73	M>I		No	ClinGen ExAC TOPMed gnomAD
rs776359239 CA379850404	73	M>K		No	ClinGen ExAC TOPMed gnomAD
rs1454223086 CA379850402	73	M>L		No	ClinGen gnomAD
rs776359239 CA5882318	73	M>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	74	K>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5882320 rs770053274	75	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1317161845 CA379850423	76	A>T		No	ClinGen TOPMed gnomAD
rs1345473085 CA379850433	78	R>G		No	ClinGen TOPMed gnomAD
rs773393238 CA5882321	78	R>Q		No	ClinGen ExAC gnomAD
rs1280416552 CA379850442	79	S>I		No	ClinGen TOPMed
CA217928777 rs920639332	80	P>S		No	ClinGen TOPMed
CA5882325 COSM3979021 rs760027500	81	E>K	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs768053857 CA5882326	82	D>H		No	ClinGen ExAC TOPMed gnomAD
CA379850457 rs768053857	82	D>N		No	ClinGen ExAC TOPMed gnomAD
CA379850466 rs1348238004	83	S>C		No	ClinGen TOPMed gnomAD
CA379850469 rs1223050872	83	S>I		No	ClinGen gnomAD
CA5882369 rs762219274	84	S>C		No	ClinGen ExAC gnomAD
rs762219274 CA379850791	84	S>R		No	ClinGen ExAC gnomAD
rs1372388131 CA379850794	84	S>T		No	ClinGen gnomAD
VAR_048205 rs2228573 RCV000956909 CA5882370	85	P>R		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP
CA217928793 rs1021128489	85	P>T		No	ClinGen Ensembl
CA5882372 rs774785781	87	A>V		No	ClinGen ExAC TOPMed gnomAD
rs752136972 CA5882374	88	A>P		No	ClinGen ExAC gnomAD
CA217928794 rs752136972	88	A>S		No	ClinGen ExAC gnomAD
CA5882375 rs752136972	88	A>T		No	ClinGen ExAC gnomAD
rs373413227 CA5882377	89	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5882378 rs373413227	89	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs373413227 CA379850829	89	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1179357383 CA379850826	89	R>S		No	ClinGen TOPMed
CA5882380 rs746111731	93	K>N		No	ClinGen ExAC gnomAD
CA379850885 rs1201356245	96	R>G		No	ClinGen TOPMed
rs769338742 CA5882384	97	Q>H		No	ClinGen ExAC gnomAD
CA5882383 rs747075720	97	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs376677864 CA217928795	98	S>G		No	ClinGen ESP gnomAD
CA379850905 rs1215038669	98	S>R		No	ClinGen TOPMed
CA217928796 rs1004066005	98	S>T		No	ClinGen TOPMed
CA217928797 rs962018945	99	M>L		No	ClinGen TOPMed
rs777250833 CA379850909	99	M>R		No	ClinGen ExAC TOPMed gnomAD
CA5882385 rs777250833	99	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1240234844 CA379850926	101	N>T		No	ClinGen TOPMed
TCGA novel	103	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379850954 rs1188710780	104	G>D		No	ClinGen gnomAD
CA217928799 rs866552090	105	L>P		No	ClinGen TOPMed gnomAD
rs866552090 CA379850964	105	L>R		No	ClinGen TOPMed gnomAD
rs762191630 CA5882386	106	R>Q		No	ClinGen ExAC gnomAD
rs1395485280 CA379850986	108	F>L		No	ClinGen gnomAD
CA5882387 rs770217561	111	R>H		No	ClinGen ExAC gnomAD
CA5882388 rs770217561	111	R>L		No	ClinGen ExAC gnomAD
TCGA novel	111	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	113	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379851040 rs1383149401	114	T>M		No	ClinGen gnomAD
rs1331429534 CA379851083	119	K>R		No	ClinGen TOPMed
rs1331429534 CA379851084	119	K>T		No	ClinGen TOPMed
CA5882391 rs752251431	121	A>V		No	ClinGen ExAC gnomAD
rs1565453273 CA379851131	125	Y>H		No	ClinGen Ensembl
CA379851146 rs112526486	126	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5882393 rs763554599	128	T>I		No	ClinGen ExAC gnomAD
rs140844268 CA5882394	129	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1235946431 CA379851185	131	D>E		No	ClinGen gnomAD
rs778770096 CA5882397	133	D>N		No	ClinGen ExAC TOPMed gnomAD
rs529300345 CA5882398	135	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA379851225 rs1241830888	137	P>R		No	ClinGen TOPMed
CA597905538 rs1565453297	139	S>L		No	ClinGen Ensembl
rs371681360 CA5882400	139	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1467046970 CA379851234	139	S>R		No	ClinGen gnomAD
CA5882401 rs747129027	140	K>E		No	ClinGen ExAC
rs1268021154 CA379851265	143	P>S		No	ClinGen gnomAD
rs781376753 CA5882403	144	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA5882404 rs748703275	144	Q>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	145	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA217928801 rs866419823	145	G>V		No	ClinGen Ensembl
rs773695276 CA5882406	147	G>S		No	ClinGen ExAC gnomAD
rs771749755 CA5882408	152	R>G		No	ClinGen ExAC gnomAD
rs1173372857 CA379851319	152	R>L		No	ClinGen gnomAD
rs775154162 CA5882409	153	S>P		No	ClinGen ExAC gnomAD
CA5882411 rs763603296	155	P>T		No	ClinGen ExAC gnomAD
CA379851337 rs1269438766	156	E>K		No	ClinGen gnomAD
CA5882413 rs761874343	157	A>T		No	ClinGen ExAC gnomAD
CA5882414 rs765070563	158	G>S		No	ClinGen ExAC TOPMed gnomAD
CA379851351 rs1265955887	158	G>V		No	ClinGen gnomAD
TCGA novel	159	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA379851356 rs750283609	159	P>L		No	ClinGen ExAC TOPMed gnomAD
rs750283609 CA5882416	159	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs750283609 CA5882415	159	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1489425976 CA379851355	159	P>S		No	ClinGen gnomAD
CA5882418 rs751857285	160	G>D		No	ClinGen ExAC gnomAD
CA379851368 rs1183124131	162	T>A		No	ClinGen gnomAD
rs755194034 CA5882419	164	V>L		No	ClinGen ExAC gnomAD
CA379851394 rs1327034245	166	S>Y		No	ClinGen gnomAD
CA379851419 rs1447258473	170	A>T		No	ClinGen TOPMed
CA217928803 rs199526740	170	A>V		No	ClinGen gnomAD
CA379851433 rs1565453374	172	G>R		No	ClinGen Ensembl
CA217928804 rs988335968	172	G>V		No	ClinGen TOPMed
rs1415185208 CA379851442	173	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs781336657 CA5882420	174	P>A		No	ClinGen ExAC gnomAD
CA379851444 rs781336657	174	P>S		No	ClinGen ExAC gnomAD
CA379851451 rs1296764361	175	A>V		No	ClinGen gnomAD
rs373588240 CA5882423	176	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA5882422 rs748173146	176	P>S		No	ClinGen ExAC gnomAD
CA5882425 rs373720232	177	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA379851461 rs1235180995	177	P>L		No	ClinGen TOPMed
rs773405081	177	P>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA379851458 rs373720232	177	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA217928806 rs373720232	177	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773405081	178	S>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs771306099 CA5882426	178	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA379851490 rs1202392375	182	P>A		No	ClinGen gnomAD
CA217928807 rs926266115	183	H>P		No	ClinGen Ensembl
rs1483246640 CA379851508	184	F>L		No	ClinGen gnomAD
TCGA novel	185	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5882428 rs746665872	185	L>V		No	ClinGen ExAC gnomAD

No associated diseases with P35318

No regional properties for P35318

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P35318

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

3 GO annotations of molecular function

Name	Definition
adrenomedullin receptor binding	Binding to an adrenomedullin receptor.
hormone activity	The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

48 GO annotations of biological process

Name	Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
adrenomedullin receptor signaling pathway	The series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell.
aging	A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
amylin receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
androgen metabolic process	The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.
animal organ regeneration	The regrowth of a lost or destroyed animal organ.
antibacterial humoral response	An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
antimicrobial humoral immune response mediated by antimicrobial peptide	An immune response against microbes mediated by anti-microbial peptides in body fluid.
branching involved in labyrinthine layer morphogenesis	The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.
calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
cAMP-mediated signaling	Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
defense response to Gram-negative bacterium	Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium	Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
developmental growth	The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
female pregnancy	The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
G protein-coupled receptor internalization	The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
hormone secretion	The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of vascular permeability	Any process that reduces the extent to which blood vessels can be pervaded by fluid.
negative regulation of vasoconstriction	Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction.
neural tube closure	The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
neuron projection regeneration	The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.
odontogenesis of dentin-containing tooth	The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
positive regulation of angiogenesis	Any process that activates or increases angiogenesis.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cytosolic calcium ion concentration	Any process that increases the concentration of calcium ions in the cytosol.
positive regulation of heart rate	Any process that activates or increases the frequency or rate of heart contraction.
positive regulation of progesterone biosynthetic process	Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process.
positive regulation of vasculogenesis	Any process that activates or increases the frequency, rate or extent of vasculogenesis.
receptor internalization	A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
regulation of systemic arterial blood pressure	The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of the force of heart contraction	Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
regulation of urine volume	Any process that modulates the amount of urine excreted from the body over a unit of time.
response to cold	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to glucocorticoid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
response to insulin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
response to lipopolysaccharide	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
response to starvation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.
response to wounding	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
spongiotrophoblast layer development	The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state.
vascular associated smooth muscle cell development	The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.
vasculogenesis	The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O62827	ADM	Pro-adrenomedullin	Bos taurus (Bovine)	PR
O77559	ADM	Pro-adrenomedullin	Canis lupus familiaris (Dog) (Canis familiaris)	PR
P53366	ADM	Pro-adrenomedullin	Sus scrofa (Pig)	PR

10	20	30	40	50	60
MKLVSVALMY	LGSLAFLGAD	TARLDVASEF	RKKWNKWALS	RGKRELRMSS	SYPTGLADVK
70	80	90	100	110	120
AGPAQTLIRP	QDMKGASRSP	EDSSPDAARI	RVKRYRQSMN	NFQGLRSFGC	RFGTCTVQKL
130	140	150	160	170	180
AHQIYQFTDK	DKDNVAPRSK	ISPQGYGRRR	RRSLPEAGPG	RTLVSSKPQA	HGAPAPPSGS

APHFL