O77559

PR
Gene name
ADM
Protein name
Pro-adrenomedullin
Names
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403817
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O77559

Entry ID Method Resolution Chain Position Source
AF-O77559-F1 Predicted AlphaFoldDB

No variants for O77559

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O77559

No associated diseases with O77559

2 regional properties for O77559

Type Name Position InterPro Accession
domain Phospholipid/glycerol acyltransferase 83 - 213 IPR002123
domain 1-acyl-sn-glycerol-3-phosphate acyltransferase 81 - 210 IPR004552

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O62827 ADM Pro-adrenomedullin Bos taurus (Bovine) PR
P35318 ADM Pro-adrenomedullin Homo sapiens (Human) PR
P53366 ADM Pro-adrenomedullin Sus scrofa (Pig) PR
10 20 30 40 50 60
MKLVPVALLY LGSLAFLGAD TARLDVASEF RKKWNKWAVS RGKRELRVSS SYPTGLAEVK
70 80 90 100 110 120
AGPAQTLIRT QDVKGASRNP QTSGPDAARI RVKRYRQSMN NFQGPRSFGC RFGTCTVQKL
130 140 150 160 170 180
AHQIYQFTDN DKDGVAPRSK ISPQGYGRRR RRSLPEPGLR RTLLFPEPRP GGAPAPRAHQ
VLANLLKM