P52009

PR
Gene name
cyn-1 (cyp-1, Y49A3A.5)
Protein name
Peptidyl-prolyl cis-trans isomerase 1
Names
PPIase 1, Cyclophilin-1, Rotamase 1
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_Y49A3A.5
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

143-192 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P52009

Entry ID Method Resolution Chain Position Source
AF-P52009-F1 Predicted AlphaFoldDB

No variants for P52009

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P52009

No associated diseases with P52009

2 regional properties for P52009

Type Name Position InterPro Accession
domain Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain 25 - 188 IPR002130
conserved_site Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site 73 - 90 IPR020892

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
cyclosporin A binding Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

2 GO annotations of biological process

Name Definition
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P47103 CPR7 Peptidyl-prolyl cis-trans isomerase CYP7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9UNP9 PPIE Peptidyl-prolyl cis-trans isomerase E Homo sapiens (Human) PR
Q3TKY6 Cwc27 Spliceosome-associated protein CWC27 homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MKFLLRASSL AGQSLRFASQ RPKVFFDVSI GEEPAGRVTM ELFNDVVPKT AENFRALCTG
70 80 90 100 110 120
EKGVGEQGVA LHFKGSKFHR IIPEFMIQGG DFTRHNGTGG ESIYGNKFKD ENFDLKHTGP
130 140 150 160 170 180
GCLSMANAGP NTNGSQFFIC TVDTPWLDGG HVVFGQVTDG MSVVKKIEKM GSRSGAPAKT
190
VTIADCGELK SE