AiPD: Autoinhibited Protein Database

Q9UNP9

Gene name	PPIE (CYP33)
Protein name	Peptidyl-prolyl cis-trans isomerase E
Names	PPIase E, Cyclophilin E, Cyclophilin-33, Rotamase E
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10450
EC number	5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

91-163 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

91-163 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

29 structures for Q9UNP9

Entry ID	Method	Resolution	Chain	Position	Source
1ZMF	X-ray	188 A	A	137-301	PDB
2CQB	NMR	-	A	1-89	PDB
2KU7	NMR	-	A	2-82	PDB
2KYX	NMR	-	A	3-83	PDB
2R99	X-ray	161 A	A	131-301	PDB
3LPY	X-ray	200 A	A/B	5-82	PDB
3MDF	X-ray	185 A	A/B	1-83	PDB
3UCH	X-ray	250 A	A	129-301	PDB
5MQF	EM	590 A	o	1-301	PDB
5YZG	EM	410 A	1	1-301	PDB
5Z56	EM	510 A	y	1-301	PDB
5Z57	EM	650 A	y	1-301	PDB
6FF7	EM	450 A	o	1-301	PDB
6ICZ	EM	300 A	y	1-301	PDB
6ID0	EM	290 A	y	1-301	PDB
6ID1	EM	286 A	y	1-301	PDB
7A5P	EM	500 A	o	1-301	PDB
7ABI	EM	800 A	o	1-301	PDB
7W59	EM	360 A	y	1-301	PDB
7W5A	EM	360 A	y	1-301	PDB
7W5B	EM	430 A	y	1-301	PDB
7ZEV	NMR	-	A	1-114	PDB
7ZEW	NMR	-	A	1-114	PDB
7ZEX	NMR	-	A	1-90	PDB
7ZEY	NMR	-	A	1-114	PDB
7ZEZ	NMR	-	A	1-90	PDB
8C6J	EM	280 A	CE	1-301	PDB
8CH6	EM	590 A	w	1-301	PDB
AF-Q9UNP9-F1	Predicted				AlphaFoldDB

210 variants for Q9UNP9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs749129226 CA786818	2	A>V		No	ClinGen ExAC gnomAD
CA786821 rs745833279	3	T>A		No	ClinGen ExAC TOPMed gnomAD
rs771607640 CA786822	3	T>I		No	ClinGen ExAC gnomAD
CA339809624 rs745833279	3	T>P		No	ClinGen ExAC TOPMed gnomAD
CA786823 rs774920247	4	T>S		No	ClinGen ExAC gnomAD
rs773524238 CA786826	5	K>E		No	ClinGen ExAC gnomAD
TCGA novel	6	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766699936 CA786828	6	R>G		No	ClinGen ExAC TOPMed gnomAD
CA339809661 rs1187358320	6	R>L		No	ClinGen TOPMed
rs766699936 CA339809657	6	R>S		No	ClinGen ExAC TOPMed gnomAD
rs990535740 CA20961867	7	V>G		No	ClinGen TOPMed gnomAD
rs767579392 CA786831	10	V>L		No	ClinGen ExAC gnomAD
rs1270829456 CA339810670	16	E>K		No	ClinGen TOPMed
rs1200873256 CA339810724	18	D>Y		No	ClinGen gnomAD
CA339810779 rs1432577835	20	K>R		No	ClinGen gnomAD
TCGA novel	20	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339810846 rs1282441068	23	H>N		No	ClinGen TOPMed
rs758313497 CA786857	25	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA339810954 rs1430128365	28	P>L		No	ClinGen gnomAD
rs1557440487 CA339811001	31	D>G		No	ClinGen Ensembl
CA339811025 rs1223265060	32	I>V		No	ClinGen gnomAD
TCGA novel	34	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA786860 rs754451607	35	I>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	36	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1368889682 CA339811121	38	P>L		No	ClinGen gnomAD
rs780742850 CA786861	40	D>N		No	ClinGen ExAC gnomAD
rs1284080272 CA339811156	41	Y>F		No	ClinGen gnomAD
rs1283154375 CA339811172	42	E>G		No	ClinGen TOPMed
rs1569626277 CA339811170	42	E>K		No	ClinGen Ensembl
TCGA novel	43	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339811185 rs1222279229	43	T>I		No	ClinGen TOPMed
CA786884 rs749011841	44	E>D		No	ClinGen ExAC gnomAD
COSM464600 CA786885 rs186973395	45	K>E	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1008215581 CA339811417	46	H>P		No	ClinGen gnomAD
CA20962859 rs1008215581	46	H>R		No	ClinGen gnomAD
rs1290102187 CA339811414	46	H>Y		No	ClinGen TOPMed gnomAD
CA786886 rs780622775	50	A>G		No	ClinGen ExAC TOPMed gnomAD
CA339811487 rs780622775	50	A>V		No	ClinGen ExAC TOPMed gnomAD
CA339811513 rs1243783735	52	V>I		No	ClinGen gnomAD
CA20962869 COSM241224 rs961502910	53	E>Q	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	55	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	55	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA786887 rs747462105	56	L>W		No	ClinGen ExAC gnomAD
rs986459693 CA20962957	59	D>N		No	ClinGen TOPMed
TCGA novel	61	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339811776 rs1285815201	61	A>V		No	ClinGen gnomAD
rs759431590 CA786901	63	A>V		No	ClinGen ExAC gnomAD
rs138799550 CA339811823	64	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1208074488 CA339811815	64	I>V		No	ClinGen TOPMed gnomAD
CA339811824 rs1462496610	65	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA339811841 rs1236674644	66	N>S		No	ClinGen gnomAD
rs113902258 CA20962973	67	M>T		No	ClinGen Ensembl
CA339812213 rs1355657463	73	F>S		No	ClinGen TOPMed
rs150373599 CA786919	75	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs767343380 CA786921	77	I>V		No	ClinGen ExAC TOPMed gnomAD
CA786922 rs775286547	78	R>H		No	ClinGen ExAC TOPMed gnomAD
rs763457871 CA786924	80	N>S		No	ClinGen ExAC gnomAD
TCGA novel	81	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	85	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA339812470 rs1332295014	85	M>V		No	ClinGen TOPMed gnomAD
rs756929050 CA786926	90	G>A		No	ClinGen ExAC TOPMed gnomAD
CA339813268 rs1450886446	96	W>*		No	ClinGen gnomAD
CA339813267 rs1209256500	96	W>L		No	ClinGen gnomAD
CA339813277 rs1265351706	98	D>N		No	ClinGen gnomAD
rs924710963 CA20963542	104	K>E		No	ClinGen Ensembl
rs775953205 CA786945	104	K>N		No	ClinGen ExAC gnomAD
CA339813327 rs1441537948	104	K>T		No	ClinGen TOPMed
rs1352892036 CA339813341	106	S>A		No	ClinGen TOPMed
CA339813343 rs1569648256	106	S>C		No	ClinGen Ensembl
CA339813350 rs1189751653	107	G>V		No	ClinGen gnomAD
CA786946 rs761382927	108	K>N		No	ClinGen ExAC gnomAD
COSM3689682 CA786947 rs764879686 COSM267239	109	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs750092753 CA786948	111	E>G		No	ClinGen ExAC gnomAD
rs762747932 CA786949	115	E>Q		No	ClinGen ExAC gnomAD
rs1457971249 CA339813408	116	E>Q		No	ClinGen gnomAD
CA20963595 rs1054552682	117	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs376529925 CA786950	118	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1163179726 CA339813423	118	G>R		No	ClinGen TOPMed
CA786951 rs753107197	119	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1458804483 CA339813440	121	P>S		No	ClinGen gnomAD
rs918702022 CA20963603	122	P>H		No	ClinGen TOPMed gnomAD
rs918702022 CA339813450	122	P>L		No	ClinGen TOPMed gnomAD
CA786952 rs756533263	123	K>R		No	ClinGen ExAC gnomAD
TCGA novel	124	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA786954 rs200484350	125	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA339813477 rs1438277009	127	Q>E		No	ClinGen TOPMed
CA786955 rs757328126	128	E>K		No	ClinGen ExAC gnomAD
CA786984 rs748811881	129	G>A		No	ClinGen ExAC gnomAD
CA339813526 rs1378019547	129	G>R		No	ClinGen gnomAD
CA339813533 rs748811881	129	G>V		No	ClinGen ExAC gnomAD
CA20964243 rs1017974068	130	E>K		No	ClinGen TOPMed
rs1301327142 CA339813559	131	P>L		No	ClinGen gnomAD
rs1016475431 CA20964254	132	I>M		No	ClinGen Ensembl
rs770390684 CA786985	132	I>V		No	ClinGen ExAC gnomAD
CA786986 rs774052244	133	A>S		No	ClinGen ExAC gnomAD
CA339813589 rs1475007167	134	K>E		No	ClinGen TOPMed
TCGA novel	135	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA20964262 rs748891149	137	R>C		No	ClinGen TOPMed gnomAD
CA786987 rs149451835	137	R>H	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs764384693 CA786988	138	S>P		No	ClinGen ExAC TOPMed gnomAD
CA339813697 rs750975872	141	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs750975872 CA786992	141	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs758471272 CA786993	144	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1320514727 CA339813775	146	I>V		No	ClinGen TOPMed
rs540102410 CA20964283	147	K>N		No	ClinGen 1000Genomes
CA339813841 rs1205398083	148	I>M		No	ClinGen gnomAD
rs766435677 CA786994	148	I>V		No	ClinGen ExAC gnomAD
CA339813895 rs1218789008	151	K>E		No	ClinGen TOPMed
CA339813909 rs1344925834	151	K>R		No	ClinGen TOPMed gnomAD
CA786996 rs139872652	152	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA786998 rs747985266	154	G>S		No	ClinGen ExAC TOPMed gnomAD
CA786999 rs756063594	155	R>C		No	ClinGen ExAC TOPMed gnomAD
rs777825153 CA787000	155	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA339813973 rs1463864979	156	I>V		No	ClinGen TOPMed
CA339814014 rs1352872542	157	Q>E		No	ClinGen gnomAD
CA339814078 rs1366964937	160	L>P		No	ClinGen TOPMed
CA20964335 rs759101916	161	R>C		No	ClinGen TOPMed
COSM3689684 rs776933148 CA787006 COSM3689683	161	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA787007 rs776933148	161	R>L		No	ClinGen ExAC gnomAD
rs573338483 CA787008	163	D>E		No	ClinGen 1000Genomes ExAC gnomAD
CA339814132 rs1557447168	164	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA20964343 rs981534733	165	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs773763047 CA787009	166	P>A		No	ClinGen ExAC TOPMed gnomAD
CA339814176 rs1305268925	166	P>R		No	ClinGen gnomAD
CA787010 rs763427310	167	M>V		No	ClinGen ExAC gnomAD
rs1354299333 CA339815918	170	E>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs757170281 CA787038 COSM909342 COSM1584509	173	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA787039 rs778694289	173	R>H		No	ClinGen ExAC TOPMed gnomAD
CA787040 rs570412863	174	C>R		No	ClinGen ExAC gnomAD
rs757897036 CA787041	175	L>P		No	ClinGen ExAC gnomAD
rs1443888316 CA339816054	177	T>A		No	ClinGen gnomAD
rs1211113379 CA339816076	178	H>R		No	ClinGen gnomAD
rs1392803623 CA339816074	178	H>Y		No	ClinGen TOPMed gnomAD
rs768302199 CA787044	180	K>E		No	ClinGen ExAC gnomAD
CA787045 rs778155074	182	F>L		No	ClinGen ExAC gnomAD
rs1412775757 CA339816182	184	F>L		No	ClinGen gnomAD
CA787046 rs375485659	186	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA787047 rs771374286	191	R>C		No	ClinGen ExAC TOPMed gnomAD
CA20967873 rs925108996	191	R>H		No	ClinGen Ensembl
CA787048 rs774718170	192	I>L		No	ClinGen ExAC gnomAD
CA339816324 rs774718170	192	I>V		No	ClinGen ExAC gnomAD
rs938075282 CA20967876	194	P>S		No	ClinGen TOPMed
rs1159248826 CA339816413	197	M>V		No	ClinGen TOPMed
rs775720566 CA787051	201	G>S		No	ClinGen ExAC TOPMed gnomAD
rs760940629 CA787052	206	H>R		No	ClinGen ExAC TOPMed gnomAD
CA787054 rs764245200	207	N>S		No	ClinGen ExAC TOPMed gnomAD
rs764245200 CA787053	207	N>T		No	ClinGen ExAC TOPMed gnomAD
CA339816605 rs1238279664	208	G>R		No	ClinGen gnomAD
rs761484384 CA787055	209	T>I		No	ClinGen ExAC gnomAD
CA339816626 rs761484384	209	T>N		No	ClinGen ExAC gnomAD
rs779462215 CA20967888	214	I>V		No	ClinGen Ensembl
rs750345757 CA787057	215	Y>C		No	ClinGen ExAC gnomAD
rs368373757 CA339816711	215	Y>D		No	ClinGen ESP ExAC gnomAD
CA787056 rs368373757	215	Y>H		No	ClinGen ESP ExAC gnomAD
rs1279330785 CA339816720	216	G>E		No	ClinGen gnomAD
CA339816732 rs1346058533	217	K>N		No	ClinGen gnomAD
CA339816737 rs1207529608	218	K>T		No	ClinGen gnomAD
rs758344472 CA339816749	219	F>L		No	ClinGen ExAC gnomAD
CA339816756 rs751095684	220	D>E		No	ClinGen ExAC TOPMed
rs765808679 CA787059 COSM909343 COSM1584507	220	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1326403489 CA339816810	227	K>Q		No	ClinGen TOPMed
rs780682561 CA787062	228	H>R		No	ClinGen ExAC gnomAD
CA787063 rs747872958	229	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs747872958 CA339816850	229	T>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	238	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1440973128 CA339817318	239	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA787084 rs758884041	241	P>R		No	ClinGen ExAC gnomAD
CA20969100 rs571843486	242	N>S		No	ClinGen Ensembl
CA339817377 rs1557456895	244	N>S		No	ClinGen Ensembl
rs780677615 CA339817414	246	S>A		No	ClinGen ExAC TOPMed gnomAD
rs866582135 CA20969106	246	S>F		No	ClinGen Ensembl
rs780677615 CA787085	246	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1213657125 CA339817439	247	Q>H		No	ClinGen gnomAD
CA787086 rs747620205	247	Q>P		No	ClinGen ExAC gnomAD
TCGA novel	248	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1466531290 CA339817487	249	F>L		No	ClinGen TOPMed gnomAD
CA20969112 rs751635665	250	L>V		No	ClinGen Ensembl
CA339817556 rs1557457059	252	C>S		No	ClinGen Ensembl
rs1425380294 CA339817562	252	C>Y		No	ClinGen TOPMed
rs768602497 CA787089	253	D>G		No	ClinGen ExAC gnomAD
CA787090 rs781344514	254	K>R		No	ClinGen ExAC gnomAD
CA339817653 rs1176864234	257	W>*		No	ClinGen TOPMed
CA339817647 rs1190538038	257	W>R		No	ClinGen gnomAD
rs748248658 CA787091	259	D>G		No	ClinGen ExAC
rs1569708461 CA339817768	264	V>G		No	ClinGen Ensembl
rs1472811462 CA339817791	266	G>R		No	ClinGen TOPMed gnomAD
CA339817813 rs1569708601	267	E>*		No	ClinGen Ensembl
rs72665281 CA787094	270	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs539934916 CA787095	272	L>V		No	ClinGen ExAC gnomAD
CA787096 rs774265713	273	D>H		No	ClinGen ExAC gnomAD
CA787098 rs369622308	274	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs766872571 CA787099	275	L>F		No	ClinGen ExAC gnomAD
rs373395278 CA787101	276	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs142456461 CA787100	276	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs868573979 CA20969306	280	A>V		No	ClinGen Ensembl
rs1413937806 CA339818238	283	S>C		No	ClinGen TOPMed
CA339818261 rs1434380171	283	S>R		No	ClinGen gnomAD
rs1370608227 CA339818282	284	K>R		No	ClinGen gnomAD
rs753108497 CA787128	286	G>R		No	ClinGen ExAC gnomAD
rs1298110721 CA339818354	288	P>S		No	ClinGen gnomAD
rs1371893524 CA339818391	289	K>T		No	ClinGen gnomAD
CA787130 rs753184327	290	Q>R		No	ClinGen ExAC gnomAD
rs1233158443 CA339818541	294	I>V		No	ClinGen gnomAD
rs778032411 CA20969347	295	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA339818565 rs749448341	296	D>H		No	ClinGen ExAC TOPMed gnomAD
CA787133 rs749448341	296	D>N		No	ClinGen ExAC TOPMed gnomAD
CA787134 rs749448341	296	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA787135 rs778524374	298	G>W		No	ClinGen ExAC gnomAD
rs549682152 CA20969361	301	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA787137 rs549682152	301	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q9UNP9

4 regional properties for Q9UNP9

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	6 - 84	IPR000504
domain	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	143 - 299	IPR002130
conserved_site	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	184 - 201	IPR020892
domain	Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif	8 - 82	IPR034168

Functions

		Description
EC Number	5.2.1.8	Cis-trans isomerases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
ficolin-1-rich granule lumen	Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
secretory granule lumen	The volume enclosed by the membrane of a secretory granule.
U2-type catalytic step 2 spliceosome	A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.

5 GO annotations of molecular function

Name	Definition
cyclosporin A binding	Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
peptidyl-prolyl cis-trans isomerase activity	Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
poly(A) binding	Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
RNA binding	Binding to an RNA molecule or a portion thereof.

5 GO annotations of biological process

Name	Definition
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
positive regulation of viral genome replication	Any process that activates or increases the frequency, rate or extent of viral genome replication.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein peptidyl-prolyl isomerization	The modification of a protein by cis-trans isomerization of a proline residue.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P47103	CPR7	Peptidyl-prolyl cis-trans isomerase CYP7	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P52009	cyn-1	Peptidyl-prolyl cis-trans isomerase 1	Caenorhabditis elegans	PR

10	20	30	40	50	60
MATTKRVLYV	GGLAEEVDDK	VLHAAFIPFG	DITDIQIPLD	YETEKHRGFA	FVEFELAEDA
70	80	90	100	110	120
AAAIDNMNES	ELFGRTIRVN	LAKPMRIKEG	SSRPVWSDDD	WLKKFSGKTL	EENKEEEGSE
130	140	150	160	170	180
PPKAETQEGE	PIAKKARSNP	QVYMDIKIGN	KPAGRIQMLL	RSDVVPMTAE	NFRCLCTHEK
190	200	210	220	230	240
GFGFKGSSFH	RIIPQFMCQG	GDFTNHNGTG	GKSIYGKKFD	DENFILKHTG	PGLLSMANSG
250	260	270	280	290	300
PNTNGSQFFL	TCDKTDWLDG	KHVVFGEVTE	GLDVLRQIEA	QGSKDGKPKQ	KVIIADCGEY

V