P47103

PR
Gene name
CPR7 (YJR032W, J1585)
Protein name
Peptidyl-prolyl cis-trans isomerase CYP7
Names
PPIase CYP7, Rotamase CYP7
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJR032W
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P47103

Entry ID Method Resolution Chain Position Source
5JHE X-ray 180 A A 1-393 PDB
AF-P47103-F1 Predicted AlphaFoldDB

8 variants for P47103

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-491333 87 S>L No SGRP
s10-491446 125 E>K No SGRP
s10-491521 150 A>P No SGRP
s10-491633 187 S>L No SGRP
s10-491659 196 V>M No SGRP
s10-491666 198 E>G No SGRP
s10-491782 237 L>F No SGRP
s10-491921 283 R>K No SGRP

No associated diseases with P47103

6 regional properties for P47103

Type Name Position InterPro Accession
repeat Tetratricopeptide repeat 1 330 - 363 IPR001440
domain Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain 8 - 196 IPR002130
repeat Tetratricopeptide repeat 240 - 273 IPR019734-1
repeat Tetratricopeptide repeat 292 - 325 IPR019734-2
repeat Tetratricopeptide repeat 330 - 363 IPR019734-3
conserved_site Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site 57 - 74 IPR020892

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
cyclosporin A binding Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
unfolded protein binding Binding to an unfolded protein.

3 GO annotations of biological process

Name Definition
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue.
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UNP9 PPIE Peptidyl-prolyl cis-trans isomerase E Homo sapiens (Human) PR
P52009 cyn-1 Peptidyl-prolyl cis-trans isomerase 1 Caenorhabditis elegans PR
10 20 30 40 50 60
MIQDPLVYLD ISIDKKPIGR IVCKLFREKA PKTTENFYKL CAGDVKSPLK DQQYLSYKGN
70 80 90 100 110 120
GFHRVVKNFM IQAGDIVFGT QKDSSSSSVG KGGCSIYADK EEVKTDDESF CYGNFEDENL
130 140 150 160 170 180
GEFVEPFTLG MANLGSPNTN NSQFFITTYA APHLNGKHSI FGQVVHGKSV VRTIENCRVD
190 200 210 220 230 240
SDGVPESDVR ISDCGVWEKT MGVPLYNASN DQIGGDVYEE YPDDDTHFGD DDFGKALEAA
250 260 270 280 290 300
NIIKESGTLL FKKKDYSNAF FKYRKSLNYI NEYMPEPDVD KERNIQFINL KMKIYLNLSL
310 320 330 340 350 360
VLFNLERYDD AIMYATYLLE MDNVPNRDQA KAYYRRGNSY LKKKRLDEAL QDYIFCKEKN
370 380 390
PDDEVIEQRI EYVNRLIEEN KEKTRKNISK FFS