Q3TKY6
Gene name |
Cwc27 |
Protein name |
Spliceosome-associated protein CWC27 homolog |
Names |
Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog, PPIase CWC27 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67285 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TKY6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TKY6-F1 | Predicted | AlphaFoldDB |
29 variants for Q3TKY6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3413013282 | 12 | N>K | No | EVA | |
| rs3389297869 | 14 | K>M | No | EVA | |
| rs3389314283 | 31 | K>E | No | EVA | |
| rs3389317524 | 39 | N>H | No | EVA | |
| rs3389300685 | 41 | I>T | No | EVA | |
| rs3389298982 | 43 | L>F | No | EVA | |
| rs3389268189 | 91 | L>* | No | EVA | |
| rs3389229414 | 93 | F>I | No | EVA | |
| rs36738180 | 156 | R>* | No | EVA | |
| rs3389294339 | 163 | S>N | No | EVA | |
| rs3403155740 | 228 | R>P* | No | EVA | |
| rs3389275802 | 231 | S>N | No | EVA | |
| rs3389259585 | 233 | H>L | No | EVA | |
| rs3389298970 | 281 | L>* | No | EVA | |
| rs3389314229 | 297 | S>R | No | EVA | |
| rs3389229356 | 299 | K>E | No | EVA | |
| rs3389303487 | 313 | E>G | No | EVA | |
| rs248596315 | 337 | I>T | No | EVA | |
| rs251769424 | 348 | A>T | No | EVA | |
| rs3389229346 | 372 | P>S | No | EVA | |
| rs3389312656 | 391 | S>Y | No | EVA | |
| rs3389303526 | 395 | Q>* | No | EVA | |
| rs3389298974 | 396 | A>V | No | EVA | |
| rs3389317530 | 427 | T>A | No | EVA | |
| rs3389259602 | 427 | T>I | No | EVA | |
| rs3389309775 | 436 | Q>* | No | EVA | |
| rs3389285262 | 443 | I>T | No | EVA | |
| rs3389317536 | 463 | R>* | No | EVA | |
| rs3389285265 | 467 | E>G | No | EVA |
No associated diseases with Q3TKY6
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| peptidyl-prolyl cis-trans isomerase activity | Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein peptidyl-prolyl isomerization | The modification of a protein by cis-trans isomerization of a proline residue. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P52009 | cyn-1 | Peptidyl-prolyl cis-trans isomerase 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNIYIQEPP | TNGKVLLKTT | AGDIDIELWS | KEAPKACRNF | IQLCLEAYYD | NTIFHRVVPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIVQGGDPTG | TGTGGESIYG | APFKDEFHSR | LRFNRRGLVA | MANAGPHDNG | SQFFFTLGRA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DELNNKHTIF | GKVTGDTVYN | MLRLTEVDID | DEERPRNPHR | IKSCEVLFNP | FDDITPREIK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPKNEKPEEE | VKKLKPKGTK | NFSLLSFGEE | AEEEEEEVNR | VSQSMKGRSK | SSHDLLKDDP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HLSSVPAVES | EKDDATGDLE | DDGEDDSAER | DEYMEDDEKN | LMRERIAKRL | KKDASASVKS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AGDGEKKPAS | RSEELRKEAR | QLKRELLAAK | QKKETAIKVE | EGREEEEAAP | DGAVAEYRRE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KQKYEALRKQ | QPKKGTSRED | QTLALLSQFK | SKLTQAITET | PENSVPEAEV | EDDEGWMSHV |
| 430 | 440 | 450 | 460 | ||
| LQFEDKTRKV | KDASMQDSDT | FEIYDPRNPV | NKRRREESKK | LLREKKERR |