P51830
PR
Gene name |
Adcy9 |
Protein name |
Adenylate cyclase type 9 |
Names |
ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, Adenylyl cyclase 9, AC9, Adenylyl cyclase type 10, ACTP10 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11515 |
EC number |
4.6.1.1: Phosphorus-oxygen lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51830
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51830-F1 | Predicted | AlphaFoldDB |
56 variants for P51830
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs217048329 | 232 | L>F | No | EVA | |
| rs260538135 | 239 | Q>H | No | EVA | |
| rs3389395162 | 300 | V>G | No | EVA | |
| rs3389412668 | 318 | M>I | No | EVA | |
| rs3389412680 | 370 | K>M | No | EVA | |
| rs3389348206 | 402 | G>V | No | EVA | |
| rs3389358480 | 458 | H>L | No | EVA | |
| rs3389367204 | 477 | C>R | No | EVA | |
| rs3413080392 | 520 | M>L | No | EVA | |
| rs3405720982 | 527 | G>S | No | EVA | |
| rs3389348166 | 557 | S>* | No | EVA | |
| rs3389391145 | 559 | V>E | No | EVA | |
| rs3389313873 | 617 | L>F | No | EVA | |
| rs3389395117 | 617 | L>S | No | EVA | |
| rs3389367186 | 640 | K>R | No | EVA | |
| rs3389313899 | 644 | G>A | No | EVA | |
| rs3389395109 | 646 | E>* | No | EVA | |
| rs252326501 | 649 | T>A | No | EVA | |
| rs3389391161 | 686 | T>P | No | EVA | |
| rs3389395139 | 727 | H>N | No | EVA | |
| rs3389406911 | 742 | F>L | No | EVA | |
| rs3389406899 | 773 | K>Q | No | EVA | |
| rs3389358504 | 795 | T>S | No | EVA | |
| rs3389399180 | 808 | K>R | No | EVA | |
| rs3389397013 | 818 | P>S | No | EVA | |
| rs3389348167 | 850 | T>K | No | EVA | |
| rs3406019386 | 850 | T>S | No | EVA | |
| rs3389394093 | 881 | Y>* | No | EVA | |
| rs3389399171 | 901 | A>V | No | EVA | |
| rs3389348146 | 902 | V>M | No | EVA | |
| rs3389399063 | 913 | C>Y | No | EVA | |
| rs3389393638 | 925 | T>I | No | EVA | |
| rs3406439530 | 926 | I>M | No | EVA | |
| rs3389393650 | 972 | R>K | No | EVA | |
| rs259735288 | 973 | R>K | No | EVA | |
| rs3405650371 | 974 | P>L | No | EVA | |
| rs3406671980 | 976 | S>G | No | EVA | |
| rs3406439653 | 978 | I>L | No | EVA | |
| rs3389406959 | 1013 | E>D | No | EVA | |
| rs3389391150 | 1039 | H>R | No | EVA | |
| rs3389399238 | 1046 | V>I | No | EVA | |
| rs3389391134 | 1058 | G>* | No | EVA | |
| rs3389367211 | 1060 | I>M | No | EVA | |
| rs3389403072 | 1079 | K>* | No | EVA | |
| rs3389393666 | 1102 | N>S | No | EVA | |
| rs3389406937 | 1117 | A>D | No | EVA | |
| rs3389348214 | 1141 | F>L | No | EVA | |
| rs3389377213 | 1152 | F>Y | No | EVA | |
| rs3389358469 | 1199 | T>I | No | EVA | |
| rs3389412685 | 1214 | R>H | No | EVA | |
| rs3389390896 | 1243 | P>S | No | EVA | |
| rs3389397075 | 1246 | T>K | No | EVA | |
| rs4152563 | 1305 | R>H | No | EVA | |
| rs239853404 | 1311 | S>P | No | EVA | |
| rs3389358553 | 1316 | V>I | No | EVA | |
| rs3389377221 | 1343 | E>D | No | EVA |
No associated diseases with P51830
4 regional properties for P51830
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 325 - 571 | IPR001054-1 |
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 1023 - 1241 | IPR001054-2 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 498 - 521 | IPR018297-1 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 1175 - 1198 | IPR018297-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.6.1.1 | Phosphorus-oxygen lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| adenylate cyclase activity | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating adrenergic receptor signaling pathway | An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| cAMP biosynthetic process | The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O60503 | ADCY9 | Adenylate cyclase type 9 | Homo sapiens (Human) | PR |
| O88444 | Adcy1 | Adenylate cyclase type 1 | Mus musculus (Mouse) | PR |
| P97490 | Adcy8 | Adenylate cyclase type 8 | Mus musculus (Mouse) | PR |
| Q8VHH7 | Adcy3 | Adenylate cyclase type 3 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASSPHQQLL | HHHSTEVSCD | SSGDSNSVRV | KINPKQLSSN | THPKHCKYSI | SSSCSSSGDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGLPRRVGGG | GRLRRQKKLP | QLFERASSRW | WDPKFDSMNL | EEACLERCFP | QTQRRFRYAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FYVGFACLLW | SIYFAVHMKS | KVIVMVVPAL | CFLVVCVGFF | LFTFTKLYAR | HYAWTSLALT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLVFALTLAA | QFQVWTPLSG | RVDSSNHTLT | ATPADTCLSQ | VGSFSICIEV | LLLLYTVMQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PLYLSLFLGV | VYSVLFETFG | YHFRNEDCYP | SPGPGALHWE | LLSRALLHVC | IHAIGIHLFV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MSQVRSRSTF | LKVGQSIMHG | KDLEVEKALK | ERMIHSVMPR | IIADDLMKQG | DEESENSVKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HATSSPKNRK | KKSSIQKAPI | AFRPFKMQQI | EEVSILFADI | VGFTKMSANK | SAHALVGLLN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLFGRFDRLC | EQTKCEKIST | LGDCYYCVAG | CPEPRADHAY | CCIEMGLGMI | KAIEQFCQEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KEMVNMRVGV | HTGTVLCGIL | GMRRFKFDVW | SNDVNLANLM | EQLGVAGKVH | ISEATAKYLD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DRYEMEDGRV | IERLGQSVVA | DQLKGLKTYL | ISGQRAKESH | CSCAEALLSG | FEVIDDSRES |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SGPRGQGTAS | PGSVSDLAQT | VKTFDNLKTC | PSCGITFAPK | SEAGAEGGTV | QNGCQDEPKT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| STKASGGPNS | KTQNGLLSPP | AEEKLTNSQT | SLCEILQEKG | RWAGVSLDQS | ALLPLRFKNI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| REKTDAHFVD | VIKEDSLMKD | YFFKPPINQF | SLNFLDQELE | RSYRTSYQEE | VIKNSPVKTF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ASATFSSLLD | VFLSTTVFLI | LSITCFLKYG | ATATPPPPAA | LAVFGADLLL | EVLSLIVSIR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MVFFLEDVMT | CTKWLLEWIA | GWLPRHCIGA | ILVSLPALAV | YSHITSEFET | NIHVTMFTGS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AVLVAVVHYC | NFCQLSSWMR | SSLATIVGAG | LLLLLHISLC | QDSSIVMSPL | DSAQNFSAQR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NPCNSSVLQD | GRRPASLIGK | ELILTFFLLL | LLVWFLNREF | EVSYRLHYHG | DVEADLHRTK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IQSMRDQADW | LLRNIIPYHV | AEQLKVSQTY | SKNHDSGGVI | FASIVNFSEF | YEENYEGGKE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| CYRVLNELIG | DFDELLSKPD | YNSIEKIKTI | GATYMAASGL | NTAQCQEGGH | PQEHLRILFE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FAKEMMRVVD | DFNNNMLWFN | FKLRVGFNHG | PLTAGVIGTT | KLLYDIWGDT | VNIASRMDTT |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| GVECRIQVSE | ESYRVLSKMG | YDFDYRGTVN | VKGKGQMKTY | LYPKCTDNGV | VPQHQLSISP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| DIRVQVDGSI | GRSPTDEIAN | LVPSVQYSDK | ASLGSDDSTQ | AKEARLSSKR | SWREPVKAEE |
| 1330 | 1340 | 1350 | |||
| RFPFGKAIEK | DSCEDIGVEE | ASELSKLNVS | KSV |