AiPD: Autoinhibited Protein Database

O60503

Gene name	ADCY9 (KIAA0520)
Protein name	Adenylate cyclase type 9
Names	ATP pyrophosphate-lyase 9, Adenylate cyclase type IX, ACIX, Adenylyl cyclase 9, AC9
Species	Homo sapiens (Human)
KEGG Pathway	hsa:115
EC number	4.6.1.1: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-94 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

16-94 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O60503

Entry ID	Method	Resolution	Chain	Position	Source
AF-O60503-F1	Predicted				AlphaFoldDB

1186 variants for O60503

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs2056001007 RCV001262985	1033	R>T	Neurodevelopmental disorder [ClinVar]	Yes	ClinVar dbSNP
CA7871911 rs56119296	2	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871912 rs752627556	2	A>S		No	ClinGen ExAC gnomAD
rs752627556 CA7871913	2	A>T		No	ClinGen ExAC gnomAD
CA7871910 rs754433408	3	S>F		No	ClinGen ExAC
rs765879734 CA7871908	4	P>A		No	ClinGen ExAC gnomAD
CA7871907 rs762248020	4	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7871909 rs765879734	4	P>S		No	ClinGen ExAC gnomAD
rs764512255 CA7871905	5	P>S		No	ClinGen ExAC gnomAD
rs776121171 CA7871903	6	H>N		No	ClinGen ExAC
CA277038079 rs568010470	6	H>P		No	ClinGen 1000Genomes
CA394579820 rs1567155029	7	Q>E		No	ClinGen Ensembl
CA7871902 rs772304800	7	Q>H		No	ClinGen ExAC
rs1046007898 CA277038071	8	Q>R		No	ClinGen TOPMed gnomAD
CA394579796 rs1379627490	11	H>D		No	ClinGen gnomAD
CA7871901 rs759652644	12	H>Q		No	ClinGen ExAC gnomAD
CA394579774 rs1212732397 CA394579775	13	H>Q		No	ClinGen TOPMed
rs1445807017 CA394579769	14	S>N		No	ClinGen gnomAD
rs1331499494 CA394579761	15	T>S		No	ClinGen gnomAD
rs1597238032 CA394579748	17	V>G		No	ClinGen Ensembl
CA394579733 rs771001767	19	C>F		No	ClinGen ExAC gnomAD
CA7871899 rs771001767	19	C>Y		No	ClinGen ExAC gnomAD
CA7871898 rs749514225	20	D>H		No	ClinGen ExAC gnomAD
CA394579716 rs769603116	22	S>C		No	ClinGen ExAC TOPMed gnomAD
CA7871896 rs769603116	22	S>G		No	ClinGen ExAC TOPMed gnomAD
CA394579689 rs1457391886	25	S>R		No	ClinGen gnomAD
CA7871894 rs781065829	26	N>S		No	ClinGen ExAC gnomAD
CA394579680 rs1224065891	27	S>G		No	ClinGen gnomAD
CA7871893 rs754488479	28	V>A		No	ClinGen ExAC gnomAD
CA277038030 rs866281724	29	R>C		No	ClinGen Ensembl
rs974633473 CA277038024	29	R>P		No	ClinGen Ensembl
rs779598125 CA7871891	32	I>F		No	ClinGen ExAC gnomAD
rs750058500 CA7871889	35	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	36	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1367923371 CA394579612	37	L>P		No	ClinGen gnomAD
rs1294765504 CA394579608	38	S>A		No	ClinGen gnomAD
CA394579605 rs1436842993	38	S>F		No	ClinGen gnomAD
rs761074346 CA7871887	39	S>F		No	ClinGen ExAC TOPMed gnomAD
CA7871885 rs768073914	40	N>K		No	ClinGen ExAC gnomAD
rs753290289 CA7871886	40	N>S		No	ClinGen ExAC gnomAD
TCGA novel	40	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370117453 CA7871884	41	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871882 rs771039334	42	H>N		No	ClinGen ExAC TOPMed gnomAD
CA394579585 rs771039334	42	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA394579574 rs1192986261	43	P>R		No	ClinGen gnomAD
rs1378608182 CA394579577	43	P>S		No	ClinGen gnomAD
rs763126371 CA7871881	44	K>E		No	ClinGen ExAC gnomAD
rs1439793065 CA394579571	44	K>T		No	ClinGen gnomAD
CA394579561 rs1219599466	45	H>Q		No	ClinGen gnomAD
rs979015601 CA277037979	45	H>R		No	ClinGen Ensembl
rs773462672 CA7871880	46	C>R		No	ClinGen ExAC
rs1019989038 CA277037973	49	S>G		No	ClinGen TOPMed
CA394579515 rs1279721401	52	S>P		No	ClinGen TOPMed
rs776562561 CA7871877	54	C>S		No	ClinGen ExAC gnomAD
CA277037955 rs3730095	56	S>R		No	ClinGen TOPMed
rs768638075 CA7871876	58	G>A		No	ClinGen ExAC TOPMed gnomAD
CA394579473 rs1219284190	58	G>R		No	ClinGen gnomAD
rs1219284190 CA394579474	58	G>W		No	ClinGen gnomAD
rs1213690327 CA394579463	59	D>E		No	ClinGen TOPMed
CA7871874 rs746941841	59	D>V		No	ClinGen ExAC TOPMed gnomAD
rs757900535 CA7871873	61	G>E		No	ClinGen ExAC gnomAD
CA394579455 CA394579456 rs1401387089	61	G>R		No	ClinGen TOPMed gnomAD
rs757900535 CA7871872	61	G>V		No	ClinGen ExAC gnomAD
CA277037924 rs1027269999	62	G>D		No	ClinGen TOPMed
CA7871869 rs147045155	63	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141403076 CA7871868	64	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141403076 CA277037912	64	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	66	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1189707806 CA394579430	66	R>P		No	ClinGen gnomAD
rs1478918264 CA394579424	67	V>A		No	ClinGen gnomAD
rs1435229101 CA394579410	70	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA394579404 rs1215592437	71	G>S		No	ClinGen gnomAD
CA7871867 rs767980128	71	G>V		No	ClinGen ExAC gnomAD
rs755610495 CA7871866	72	R>G		No	ClinGen ExAC gnomAD
rs543810324 CA7871865	72	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs755610495 CA394579399	72	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA277037887 rs3730096	73	L>M		No	ClinGen Ensembl
rs766419542 CA7871864	74	R>C		No	ClinGen ExAC gnomAD
rs1298480719 CA394579388	74	R>L		No	ClinGen gnomAD
CA7871863 rs747861796	75	R>S		No	ClinGen ExAC
rs773308825 CA7871860	77	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1175396512 CA394579369	77	K>T		No	ClinGen TOPMed
rs765384924 CA7871859	78	K>Q		No	ClinGen ExAC gnomAD
CA7871858 rs762008889	78	K>R		No	ClinGen ExAC gnomAD
CA7871857 rs776473094	79	L>V		No	ClinGen ExAC gnomAD
CA394579318 rs1466953011	82	L>P		No	ClinGen gnomAD
TCGA novel	82	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7871856 rs768406341	82	L>V		No	ClinGen ExAC gnomAD
CA394579289 rs1174368720	84	E>Q		No	ClinGen TOPMed gnomAD
CA394579271 rs1467421242	85	R>G		No	ClinGen gnomAD
rs374090597 CA277037829	86	A>V		No	ClinGen ESP TOPMed
CA7871854 rs775447524	87	S>C		No	ClinGen ExAC gnomAD
CA394579239 rs1278412037	87	S>T		No	ClinGen TOPMed
CA394579141 rs1193160523	92	D>N		No	ClinGen gnomAD
CA394579121 rs1476734982	93	P>T		No	ClinGen gnomAD
rs139324997 CA7871853	94	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871852 rs139324997	94	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA277037817 rs575082493	98	V>A		No	ClinGen 1000Genomes TOPMed gnomAD
CA7871850 rs757033157	99	N>K		No	ClinGen ExAC TOPMed gnomAD
rs748944336 CA7871849	100	L>Q		No	ClinGen ExAC gnomAD
rs755373968 CA7871847	102	E>V		No	ClinGen ExAC gnomAD
rs1275618342 CA394578948	103	A>D		No	ClinGen TOPMed
rs1436273390 CA394578941	104	C>S		No	ClinGen TOPMed
TCGA novel	104	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394578927 rs1334856634	106	E>D		No	ClinGen gnomAD
rs756054360 CA277037804	106	E>G		No	ClinGen Ensembl
CA394578932 rs1379046528	106	E>K		No	ClinGen TOPMed gnomAD
rs766841271 CA7871845	107	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1401077456 CA394578922	107	R>H		No	ClinGen TOPMed gnomAD
CA394578923 rs1401077456	107	R>L		No	ClinGen TOPMed gnomAD
rs766841271 CA394578925	107	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1170239251 CA394578919	108	C>R		No	ClinGen gnomAD
CA394578907 rs1220928449	109	F>C		No	ClinGen Ensembl
CA394578887 rs1398415416	112	T>S		No	ClinGen TOPMed
CA394578882 rs1370031476	113	Q>E		No	ClinGen gnomAD
rs1327708133 CA394578873	114	R>H		No	ClinGen TOPMed
CA7871843 rs750572939	114	R>S		No	ClinGen ExAC gnomAD
CA7871841 rs762058083	115	R>L		No	ClinGen ExAC TOPMed gnomAD
rs762058083 CA7871842	115	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA394578867 rs1597237616	116	F>L		No	ClinGen Ensembl
CA394578865 rs1597237616	116	F>V		No	ClinGen Ensembl
rs376968312 CA277037783	120	L>V		No	ClinGen ESP TOPMed gnomAD
rs776808117 CA394578828	121	F>L		No	ClinGen ExAC TOPMed gnomAD
rs763895687 CA7871839	123	I>L		No	ClinGen ExAC gnomAD
rs763895687 CA394578818	123	I>V		No	ClinGen ExAC gnomAD
rs775297017 CA7871837	124	G>C		No	ClinGen ExAC TOPMed gnomAD
rs775297017 CA394578812	124	G>R		No	ClinGen ExAC TOPMed gnomAD
rs892102546 CA277037763	125	F>L		No	ClinGen Ensembl
CA394578798 rs1211895946	126	A>V		No	ClinGen TOPMed
CA394578793 rs1313597002	127	C>S		No	ClinGen gnomAD
rs770534868 CA7871833	128	L>F		No	ClinGen ExAC gnomAD
CA394578775 rs1597237557	130	W>G		No	ClinGen Ensembl
CA277037755 rs936383709	131	S>G		No	ClinGen Ensembl
rs1393106457 CA394578755	132	I>M		No	ClinGen gnomAD
rs777520727 CA7871831	133	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA394578736 rs1383108014	135	A>E		No	ClinGen gnomAD
rs768904794 CA7871830	135	A>T		No	ClinGen ExAC gnomAD
rs780267565 CA7871828	137	H>R		No	ClinGen ExAC TOPMed gnomAD
rs200248947 CA7871827	138	M>L		No	ClinGen ExAC TOPMed gnomAD
rs200248947 CA394578721	138	M>V		No	ClinGen ExAC TOPMed gnomAD
CA394578707 rs750860680 CA394578708	139	R>S		No	ClinGen ExAC TOPMed gnomAD
rs750363911 CA277037716	140	S>Y		No	ClinGen TOPMed gnomAD
CA394578697 rs1488363767	141	R>I		No	ClinGen gnomAD
CA7871823 rs754087926	142	L>V		No	ClinGen ExAC gnomAD
CA394578690 rs1219505152	143	I>L		No	ClinGen gnomAD
CA7871821 rs760401817	144	V>G		No	ClinGen ExAC TOPMed gnomAD
CA277037688 rs780969833	145	M>V		No	ClinGen TOPMed
CA7871819 rs767211997	146	V>A		No	ClinGen ExAC gnomAD
CA7871817 rs774411935	147	A>V		No	ClinGen ExAC TOPMed gnomAD
CA394578659 rs1325217251	148	P>A		No	ClinGen TOPMed
CA394578655 rs1363549446	148	P>L		No	ClinGen gnomAD
TCGA novel	149	A>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	149	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA277037669 rs988893119	151	C>G		No	ClinGen TOPMed gnomAD
rs3730098 CA7871814	153	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394578627 rs3730098	153	L>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394578609 rs1486206946	156	C>Y		No	ClinGen TOPMed
rs1479243093 CA394578601	157	V>A		No	ClinGen gnomAD
rs769541796 CA7871813	157	V>M		No	ClinGen ExAC gnomAD
TCGA novel	158	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1196255044 CA394578584	160	F>L		No	ClinGen gnomAD
rs1203860717 CA394578554	164	F>C		No	ClinGen gnomAD
rs559120093 CA7871809	164	F>L		No	ClinGen 1000Genomes ExAC gnomAD
rs757336207 CA7871808	166	K>N		No	ClinGen ExAC gnomAD
rs1263678822 CA394578541	166	K>R		No	ClinGen TOPMed
rs777817807 CA7871805	167	L>R		No	ClinGen ExAC gnomAD
CA394578537 rs753858086	167	L>V		No	ClinGen ExAC gnomAD
rs944073479 CA277037622	168	Y>C		No	ClinGen TOPMed gnomAD
rs376711313 CA7871802	169	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376711313 CA7871803	169	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1339557327 CA394578524	169	A>V		No	ClinGen gnomAD
rs751581722 CA394578523	170	R>G		No	ClinGen ExAC TOPMed gnomAD
CA394578521 rs1475963820	170	R>Q		No	ClinGen TOPMed
rs751581722 CA7871800	170	R>W		No	ClinGen ExAC TOPMed gnomAD
rs570699984 CA7871799	171	H>D		No	ClinGen 1000Genomes ExAC gnomAD
CA394578515 rs1162302294	171	H>L		No	ClinGen TOPMed
CA394578499 rs1453783151	173	A>V		No	ClinGen TOPMed
rs142649683 CA7871796	175	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA394578479 rs1478370114	176	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs746163052 CA7871792	178	A>P		No	ClinGen ExAC gnomAD
rs746163052 CA7871793	178	A>S		No	ClinGen ExAC gnomAD
rs774854033 CA394578468	179	L>F		No	ClinGen ExAC gnomAD
CA394578467 rs1313846833	179	L>H		No	ClinGen TOPMed
rs774854033 CA7871791	179	L>V		No	ClinGen ExAC gnomAD
rs1260274417 CA394578457	181	L>V		No	ClinGen gnomAD
rs1219412837 CA394578453	182	L>M		No	ClinGen gnomAD
CA394578444 rs1450203334	183	V>E		No	ClinGen gnomAD
CA394578445 rs1450203334	183	V>G		No	ClinGen gnomAD
rs1268181203 CA394578446	183	V>L		No	ClinGen gnomAD
rs777948652 CA7871788	185	A>T		No	ClinGen ExAC gnomAD
CA7871787 rs190107269	186	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA394578418 rs1170954189	188	L>M		No	ClinGen gnomAD
CA7871786 rs370902956	190	A>T		No	ClinGen ESP ExAC gnomAD
CA394578404 rs1419334163	190	A>V		No	ClinGen gnomAD
CA394578399 rs1166486146	191	Q>R		No	ClinGen gnomAD
rs72556392 CA394578388	192	F>L		No	ClinGen TOPMed
CA7871785 rs781234631	195	L>S		No	ClinGen ExAC gnomAD
rs548157811 CA7871784	196	T>K		No	ClinGen 1000Genomes ExAC gnomAD
rs548157811 CA277037538	196	T>R		No	ClinGen 1000Genomes ExAC gnomAD
rs374051508 CA7871783	197	P>A		No	ClinGen ExAC TOPMed gnomAD
CA394578338 rs1270666820	201	R>C		No	ClinGen gnomAD
CA7871780 rs750360400	201	R>H		No	ClinGen ExAC gnomAD
rs761188131 CA7871779	202	G>A		No	ClinGen ExAC TOPMed gnomAD
rs761188131 CA7871778	202	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1356724708 CA394578335	202	G>S		No	ClinGen TOPMed gnomAD
CA7871777 rs143296765	203	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA394578323 rs1445635187	204	S>G		No	ClinGen gnomAD
rs565323545 CA277037502	205	S>C		No	ClinGen 1000Genomes TOPMed gnomAD
rs147707598 CA7871776	206	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA277037475 rs377300070	207	L>I		No	ClinGen ESP TOPMed
CA394578295 rs1174760230	208	T>K		No	ClinGen TOPMed
CA394578294 rs1174760230	208	T>M		No	ClinGen TOPMed
rs774765745 CA7871775	209	A>D		No	ClinGen ExAC TOPMed gnomAD
CA394578292 rs1159680210	209	A>T		No	ClinGen gnomAD
CA7871774 rs774765745	209	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7871773 rs771254861	210	T>A		No	ClinGen ExAC gnomAD
CA7871772 rs749847952	210	T>I		No	ClinGen ExAC gnomAD
CA394578289 rs771254861	210	T>P		No	ClinGen ExAC gnomAD
TCGA novel	211	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394578275 rs1441874703	212	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7871770 rs769951663	213	P>L		No	ClinGen ExAC gnomAD
CA7871767 rs755314870	215	D>G		No	ClinGen ExAC TOPMed gnomAD
CA7871768 rs372461075	215	D>H		No	ClinGen ExAC gnomAD
rs372461075 CA394578263	215	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs780039488 CA7871765	217	C>G		No	ClinGen ExAC TOPMed gnomAD
CA7871764 rs750404297	217	C>W		No	ClinGen ExAC gnomAD
rs1335201294 CA394578239	218	L>F		No	ClinGen TOPMed
rs1355729315 CA394578242	218	L>S		No	ClinGen gnomAD
CA394578233 rs1309416274	219	S>F		No	ClinGen gnomAD
TCGA novel	221	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1222731167 CA394578218	222	G>R		No	ClinGen TOPMed gnomAD
CA7871761 rs532077124	226	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA394578177 rs1436683498	227	C>F		No	ClinGen gnomAD
CA277037359 rs892137966	228	I>V		No	ClinGen gnomAD
TCGA novel	230	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA277037357 rs201211738	230	V>M		No	ClinGen ESP gnomAD
TCGA novel	231	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	232	F>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362978468 CA394578138	233	L>S		No	ClinGen TOPMed gnomAD
rs1400222331 CA394578132	234	L>F		No	ClinGen gnomAD
CA7871759 rs61731442	236	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760361419 CA7871758	236	T>I		No	ClinGen ExAC gnomAD
rs766756605 COSM3691002 CA7871756	237	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
TCGA novel	238	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1489121445 CA394578107	238	M>T		No	ClinGen gnomAD
COSM249236 rs763267565 CA7871755	239	H>Y	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA277037335 rs1052767711	241	P>A		No	ClinGen TOPMed gnomAD
rs1344439158 CA394578080	242	L>S		No	ClinGen gnomAD
rs1433462978 CA394578059	245	S>N		No	ClinGen TOPMed
rs1175766949 CA394578052	246	L>S		No	ClinGen TOPMed
rs776612058 CA7871750	247	C>*		No	ClinGen ExAC TOPMed gnomAD
CA7871751 rs762374861	247	C>F		No	ClinGen ExAC TOPMed gnomAD
CA394578038 rs1296621515	248	L>R		No	ClinGen TOPMed
CA394578028 rs1597237062	250	V>G		No	ClinGen Ensembl
rs768831553 CA7871749	251	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	253	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1343569759 CA394577577	254	V>I		No	ClinGen gnomAD
rs1178319547 CA394577570	255	L>I		No	ClinGen gnomAD
rs200048380 CA277037297	257	E>*		No	ClinGen Ensembl
rs747253577 CA277037292	258	T>A		No	ClinGen ExAC TOPMed gnomAD
rs747253577 CA7871748	258	T>S		No	ClinGen ExAC TOPMed gnomAD
rs368901949 CA394577528	261	Y>C		No	ClinGen ESP ExAC gnomAD
rs368901949 CA7871747	261	Y>F		No	ClinGen ESP ExAC gnomAD
rs1174500970 CA394577515	263	F>V		No	ClinGen gnomAD
CA394577506 rs1478684312	264	R>P		No	ClinGen TOPMed gnomAD
rs1478684312 CA394577505	264	R>Q		No	ClinGen TOPMed gnomAD
CA277037288 rs72556391	267	A>S		No	ClinGen Ensembl
rs932826873 CA277037281	270	P>L		No	ClinGen TOPMed
CA394577464 rs932826873	270	P>R		No	ClinGen TOPMed
CA7871745 rs745590145	270	P>S		No	ClinGen ExAC TOPMed gnomAD
CA394577460 rs757209625	271	S>*		No	ClinGen ExAC TOPMed gnomAD
rs757209625 CA7871743	271	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7871744 rs757209625	271	S>W		No	ClinGen ExAC TOPMed gnomAD
CA7871741 rs777313389	272	P>L		No	ClinGen ExAC TOPMed gnomAD
rs752382002 CA7871739	273	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1168785469 CA394577441	275	G>R		No	ClinGen TOPMed
rs1382222998 CA394577435	276	A>D		No	ClinGen gnomAD
CA277037246 rs1028325436	276	A>T		No	ClinGen TOPMed
CA7871735 rs765602708	278	H>P		No	ClinGen ExAC TOPMed gnomAD
rs1405359188 CA394577417	279	W>S		No	ClinGen gnomAD
rs558982401 CA7871733	280	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA7871732 rs768888768	283	S>N		No	ClinGen ExAC gnomAD
CA394577377 rs868541812	285	G>A		No	ClinGen TOPMed
CA277037229 rs868541812	285	G>E		No	ClinGen TOPMed
TCGA novel	286	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394577366 rs1426708299	287	L>P		No	ClinGen TOPMed gnomAD
CA394577363 rs1316894899	288	H>D		No	ClinGen TOPMed
CA394577357 rs746100827	288	H>Q		No	ClinGen ExAC gnomAD
CA394577360 rs1182333700	288	H>R		No	ClinGen gnomAD
CA277037212 rs1042847369	289	G>C		No	ClinGen TOPMed
rs778614555 CA7871727	289	G>V		No	ClinGen ExAC gnomAD
rs762721284 CA394577332	292	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA277037206 rs1011387266	292	H>R		No	ClinGen TOPMed
CA7871725 rs749207045	296	V>F		No	ClinGen ExAC gnomAD
TCGA novel	299	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs969206888 CA14275568	299	F>V		No	ClinGen Ensembl
rs1334785327 CA394577283	300	V>D		No	ClinGen gnomAD
CA7871722 rs182142664	300	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7871721 rs182142664	300	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394577282 rs1167320340	301	M>L		No	ClinGen TOPMed
CA7871720 rs754624245	301	M>T		No	ClinGen ExAC gnomAD
CA394577281 rs1167320340	301	M>V		No	ClinGen TOPMed
rs751199997 CA7871719	302	S>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	302	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7871717 rs757597955	303	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs576483205 CA7871716	308	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA277037068 rs867701778	309	T>A		No	ClinGen Ensembl
rs556349980 CA7871715	309	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA394577228 rs867701778	309	T>P		No	ClinGen Ensembl
rs1439974261 CA394577207	312	K>R		No	ClinGen TOPMed gnomAD
CA7871712 rs537274554	313	V>A		No	ClinGen 1000Genomes ExAC gnomAD
rs375980146 CA7871713	313	V>M		No	ClinGen ESP ExAC gnomAD
rs1479871377 CA394577195	314	G>A		No	ClinGen gnomAD
CA277037042 rs956875050	315	Q>R		No	ClinGen TOPMed
rs1339551930 CA394577181	316	S>F		No	ClinGen TOPMed
rs568140024 CA7871710	317	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs770666782 CA7871709	318	M>R		No	ClinGen ExAC gnomAD
CA394577172 rs1415189861	318	M>V		No	ClinGen TOPMed
CA394577156 rs1242429238	320	G>W		No	ClinGen gnomAD
rs1336380199 CA394577132	323	L>R		No	ClinGen gnomAD
CA394577101 rs1306562915	328	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1369534593 CA394577063	333	M>T		No	ClinGen gnomAD
CA277037024 rs372743404	333	M>V		No	ClinGen ESP
CA7871706 rs769785025	340	R>G		No	ClinGen ExAC gnomAD
CA7871704 rs780726526	340	R>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs780726526 CA7871705	340	R>T		No	ClinGen ExAC TOPMed gnomAD
rs754458281 CA7871703	341	I>V		No	ClinGen ExAC gnomAD
rs928250503 CA277036990	342	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	343	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394576993 rs779690355	344	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs779690355 CA7871701	344	D>Y		No	ClinGen ExAC gnomAD
CA7871700 rs757575136	346	L>F		No	ClinGen ExAC gnomAD
CA394576973 rs1271553193	347	M>L		No	ClinGen gnomAD
rs1200578115 CA394576919	350	G>V		No	ClinGen gnomAD
CA394576893 rs1490276002	352	E>*		No	ClinGen gnomAD
rs1490276002 CA394576894	352	E>K		No	ClinGen gnomAD
TCGA novel	352	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369684993 CA7871699	353	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs751868048	353	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs764548396 CA7871697	354	S>N		No	ClinGen ExAC TOPMed gnomAD
rs756727246 CA7871696	356	N>S		No	ClinGen ExAC TOPMed gnomAD
rs146513626 CA277036961	358	V>I		No	ClinGen ESP TOPMed gnomAD
rs146513626 CA394576791	358	V>L		No	ClinGen ESP TOPMed gnomAD
CA394576756 rs1314132001	360	R>K		No	ClinGen gnomAD
rs2230738 CA394576749	360	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1404132897 CA394576741	361	H>L		No	ClinGen gnomAD
CA277036942 rs867660253	362	A>V		No	ClinGen Ensembl
rs1567153968 CA394576711	363	T>N		No	ClinGen Ensembl
CA7871693 rs145790925	364	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs145790925 CA7871692	364	S>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1159195754 CA394576654	366	P>L		No	ClinGen TOPMed
CA394576651 rs1416549660	367	K>E		No	ClinGen gnomAD
CA7871691 rs766569464	368	N>D		No	ClinGen ExAC gnomAD
rs1399055693 CA394576617	369	R>G		No	ClinGen TOPMed
CA7871689 rs773061605	372	K>E		No	ClinGen ExAC gnomAD
CA394576539 rs1487646686	373	S>F		No	ClinGen gnomAD
TCGA novel	373	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769550957 CA7871688	374	S>F		No	ClinGen ExAC gnomAD
rs1480318921 CA394576500	376	Q>P		No	ClinGen gnomAD
rs748103177 CA7871687	378	A>G		No	ClinGen ExAC TOPMed gnomAD
CA394576440 rs1446904270	380	I>V		No	ClinGen TOPMed
rs77179994 CA277036922	381	A>D		No	ClinGen Ensembl
CA394576421 rs1423803239	381	A>P		No	ClinGen Ensembl
TCGA novel	385	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	389	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs146234753 CA7871686	390	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA394576314 rs1597236628	391	E>D		No	ClinGen Ensembl
rs1203445175 CA394576320	391	E>Q		No	ClinGen gnomAD
rs1285862685 CA394576285	395	I>M		No	ClinGen TOPMed
CA277036899 rs900011883	400	I>T		No	ClinGen Ensembl
rs1041197324 CA277036892	405	K>N		No	ClinGen gnomAD
CA394576131 rs1213446163	406	M>L		No	ClinGen TOPMed
CA394576089 rs1321227540	408	A>T		No	ClinGen gnomAD
rs368028914 CA7871682	414	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871680 rs778333072	421	D>H		No	ClinGen ExAC TOPMed gnomAD
rs778333072 CA7871681	421	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA394575880 rs778333072	421	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA394575830 rs1467893003	424	G>S		No	ClinGen gnomAD
CA7871679 rs756499869	425	R>S		No	ClinGen ExAC gnomAD
CA394575783 rs1597236541	427	D>A		No	ClinGen Ensembl
CA7871675 rs751721888 CA394575734	431	E>D		No	ClinGen ExAC gnomAD
CA394575720 rs1203348462	433	T>I		No	ClinGen gnomAD
rs750592614 CA7871672	438	I>F		No	ClinGen ExAC gnomAD
CA394575683 rs1338456430	438	I>S		No	ClinGen gnomAD
rs1329057812 CA394575662	442	G>R		No	ClinGen TOPMed
CA277036803 rs1011355973	444	C>G		No	ClinGen TOPMed gnomAD
CA394575648 rs1011355973	444	C>S		No	ClinGen TOPMed gnomAD
CA7871668 rs768695964	444	C>S		No	ClinGen ExAC gnomAD
rs1410909710 CA394575636	445	Y>*		No	ClinGen TOPMed gnomAD
rs760522585 CA7871667	445	Y>H		No	ClinGen ExAC gnomAD
CA394575619 rs1237196606	448	V>M		No	ClinGen TOPMed
TCGA novel	450	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394575598 rs1166720360	451	C>F		No	ClinGen gnomAD
CA277036785 rs267604544	452	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA7871665 rs267604544	452	P>T		No	ClinGen 1000Genomes ExAC gnomAD
CA394575582 rs1442803909 CA394575583	453	E>D		No	ClinGen gnomAD
CA394575589 rs1183037749	453	E>K		No	ClinGen gnomAD
CA394575585 rs1212912328	453	E>V		No	ClinGen TOPMed gnomAD
CA277036779 rs919904291	454	P>L		No	ClinGen Ensembl
rs555844213 CA277036780	454	P>S		No	ClinGen gnomAD
CA7871663 rs778668576	455	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA394575573 rs1454638576	456	A>T		No	ClinGen TOPMed
CA277036761 rs553450429	457	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs553450429 CA7871661	457	D>Y		No	ClinGen ExAC gnomAD
CA394575548 rs1360029703	459	A>V		No	ClinGen gnomAD
CA394575544 rs1243169687	460	Y>C		No	ClinGen gnomAD
rs1374827118 CA394575534	461	C>F		No	ClinGen gnomAD
rs1279775912 CA394575515	464	E>Q		No	ClinGen gnomAD
rs1279089422 CA394575484	468	G>A		No	ClinGen gnomAD
rs1335610846 CA394575478	469	M>T		No	ClinGen gnomAD
rs1402138976 CA394575480	469	M>V		No	ClinGen TOPMed gnomAD
COSM378209 CA7871657 rs780202392	471	K>M	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1366756354 CA394575454	472	A>V		No	ClinGen gnomAD
CA394575451 rs1422823034	473	I>F		No	ClinGen TOPMed gnomAD
rs750643399 CA7871655	473	I>N		No	ClinGen ExAC gnomAD
rs1422823034 CA394575453	473	I>V		No	ClinGen TOPMed gnomAD
rs762008865 CA7871653	474	E>D		No	ClinGen ExAC gnomAD
CA394575421 rs1567153730	477	C>F		No	ClinGen Ensembl
rs1052960850 CA277036703	478	Q>R		No	ClinGen TOPMed gnomAD
CA394575394 rs1201292164	480	K>N		No	ClinGen gnomAD
TCGA novel	481	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7871652 rs561305813	481	K>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1293349685 CA394575391	481	K>T		No	ClinGen TOPMed gnomAD
rs1442487024 CA394575376	483	M>L		No	ClinGen TOPMed
CA7871651 rs763763787	484	V>M		No	ClinGen ExAC gnomAD
rs1220075332 CA394575342	487	R>S		No	ClinGen gnomAD
rs775201693 CA277036695	490	V>G		No	ClinGen gnomAD
TCGA novel	490	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7871650 rs760715810	492	T>M		No	ClinGen ExAC gnomAD
rs1348071139 CA394575303	494	T>A		No	ClinGen gnomAD
rs1284749752 CA394575296	495	V>I		No	ClinGen gnomAD
rs759050637 CA7871647	497	C>*		No	ClinGen ExAC gnomAD
TCGA novel	498	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	501	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346467918 CA394575252	502	M>K		No	ClinGen gnomAD
CA277036654 rs200124999	503	R>G		No	ClinGen Ensembl
rs774163987 CA7871646	503	R>S		No	ClinGen ExAC TOPMed gnomAD
rs748890582 CA7871645	504	R>S		No	ClinGen ExAC gnomAD
rs1597236269 CA394575233	505	F>V		No	ClinGen Ensembl
TCGA novel	509	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	510	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747579417 CA7871641	513	D>H		No	ClinGen ExAC gnomAD
CA394575167 rs1406093665	514	V>M		No	ClinGen TOPMed gnomAD
rs1597236253 CA394575158	515	N>T		No	ClinGen Ensembl
CA394575127 rs780468630	520	M>L		No	ClinGen ExAC gnomAD
CA7871640 rs780468630	520	M>V		No	ClinGen ExAC gnomAD
rs778957387 CA7871637	524	G>A		No	ClinGen ExAC gnomAD
rs1272349904 CA394575099	524	G>R		No	ClinGen TOPMed
CA394575094 rs1242242611	525	V>M		No	ClinGen TOPMed gnomAD
CA7871635 rs371561050	527	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1469842444 CA394575072	528	K>R		No	ClinGen TOPMed
CA394575064 rs1597236208	529	V>G		No	ClinGen Ensembl
rs1597236206 CA394575060	530	H>P		No	ClinGen Ensembl
CA277036592 rs72556393	531	I>N		No	ClinGen Ensembl
rs1265100094 CA394575038	533	E>V		No	ClinGen TOPMed
CA394575033 rs1451023510	534	A>D		No	ClinGen TOPMed
rs752686280 CA7871632	534	A>P		No	ClinGen ExAC gnomAD
rs1597236177 CA394575029	535	T>A		No	ClinGen Ensembl
CA7871631 rs767505370	535	T>I		No	ClinGen ExAC TOPMed gnomAD
CA7871629 rs565530412	537	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765960096 CA7871628	538	Y>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	538	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs534906920 CA277036570	540	D>H		No	ClinGen Ensembl
rs148530006 CA7871627	541	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
COSM178873 rs772697228 CA7871626	544	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA7871624 rs374304621	546	E>D		No	ClinGen ESP ExAC gnomAD
rs144747548 CA7871625	546	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871623 rs545435610	547	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7871622 rs772631736	548	G>R		No	ClinGen ExAC gnomAD
CA277036534 rs1028632033	550	V>I		No	ClinGen TOPMed
rs779012578 CA7871620	551	I>V		No	ClinGen ExAC TOPMed gnomAD
CA394574908 rs1244428187	553	R>Q		No	ClinGen gnomAD
CA394574897 rs1399804998	555	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA394574890 rs1460578914	556	Q>R		No	ClinGen gnomAD
rs777791572 CA7871617	557	S>R		No	ClinGen ExAC gnomAD
rs767419142 CA7871614 CA7871616	558	V>L		No	ClinGen ExAC TOPMed gnomAD
rs767419142 CA7871615 COSM1182053	558	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
TCGA novel	559	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394574858 rs1296928581	561	D>E		No	ClinGen gnomAD
CA7871612 RCV000971153 rs52791170	564	K>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs766014253 CA7871611	564	K>T		No	ClinGen ExAC gnomAD
CA277014685 rs974084624	565	G>D		No	ClinGen Ensembl
TCGA novel	566	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394581101 rs1358886221	566	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	568	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394581082 rs1317725141	568	T>I		No	ClinGen gnomAD
CA7871576 rs375887137	572	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA394581061 rs748406740	572	S>P		No	ClinGen ExAC TOPMed gnomAD
CA7871578 rs748406740	572	S>T		No	ClinGen ExAC TOPMed gnomAD
CA7871577 rs375887137	572	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs527706058 CA277014667	574	Q>P		No	ClinGen Ensembl
CA394581042 rs1157829648	575	R>T		No	ClinGen TOPMed
CA394581033 rs1402669553	576	A>V		No	ClinGen TOPMed
rs758306629 CA7871573	578	E>K		No	ClinGen ExAC TOPMed gnomAD
CA394581024 rs758306629	578	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs778307855 CA7871572	579	S>C		No	ClinGen ExAC gnomAD
CA7871571 rs778307855	579	S>F		No	ClinGen ExAC gnomAD
rs144065949 CA7871570 RCV000906335	580	R>C		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA394581011 rs1362893267	580	R>H		No	ClinGen gnomAD
CA394580988 rs1471821175	583	C>S		No	ClinGen gnomAD
rs1431883830 CA394580982	584	A>S		No	ClinGen gnomAD
rs763678836 CA7871568	586	A>T		No	ClinGen ExAC gnomAD
rs1597160753 CA394580953	588	L>P		No	ClinGen Ensembl
rs760308458 CA7871567	589	S>F		No	ClinGen ExAC TOPMed gnomAD
CA7871565 rs766737348	592	E>V		No	ClinGen ExAC TOPMed gnomAD
rs763421336 CA7871564	593	V>I		No	ClinGen ExAC gnomAD
rs1222869446 CA394580917	594	I>T		No	ClinGen gnomAD
rs1283681015 CA394580920	594	I>V		No	ClinGen TOPMed gnomAD
rs1382301876 CA394580902	596	G>D		No	ClinGen gnomAD
CA7871562 rs765267200	596	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1318198374 CA394580885 CA394580886	599	V>L		No	ClinGen TOPMed gnomAD
CA7871560 rs776834880	602	G>D		No	ClinGen ExAC gnomAD
CA7871559 rs769064622	603	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7871558 rs747200497	604	R>S		No	ClinGen ExAC TOPMed gnomAD
CA394580853 rs1205300450	605	G>R		No	ClinGen TOPMed
CA7871557 rs775196337	606	Q>R		No	ClinGen ExAC gnomAD
CA7871556 rs771848877	607	G>E		No	ClinGen ExAC gnomAD
rs1435663987 CA394580835	608	T>A		No	ClinGen TOPMed
rs745823164 CA7871555	608	T>I		No	ClinGen ExAC gnomAD
rs150452337 CA7871554	609	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs745357854 CA7871551	612	G>E		No	ClinGen ExAC gnomAD
TCGA novel	614	V>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA277014567 rs193292810	615	S>I		No	ClinGen 1000Genomes gnomAD
rs193292810 CA394580790	615	S>T		No	ClinGen 1000Genomes gnomAD
rs755805807 CA7871550	618	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1597160644 CA394580763	619	Q>R		No	ClinGen Ensembl
CA394580758 rs1434163106	620	T>A		No	ClinGen TOPMed
CA7871549 rs752375588	624	F>L		No	ClinGen ExAC gnomAD
CA277014543 rs79644398	624	F>S		No	ClinGen Ensembl
rs1454288972 CA394580719	626	N>D		No	ClinGen gnomAD
rs1383105495 CA394580706	627	L>R		No	ClinGen gnomAD
CA7871548 rs766679285	628	K>Q		No	ClinGen ExAC gnomAD
rs1597151710 CA394580683	629	T>P		No	ClinGen Ensembl
CA277002214 rs984781815	629	T>S		No	ClinGen TOPMed
rs770923723 CA7871531	630	C>Y		No	ClinGen ExAC gnomAD
CA7871530 rs140567074	631	P>L		No	ClinGen ESP ExAC gnomAD
CA394580669 rs1165709276	631	P>S		No	ClinGen TOPMed
rs148220141 CA7871529	632	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA277002185 rs994169231	633	C>R		No	ClinGen TOPMed gnomAD
rs780834261 CA7871526	634	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1047946477 CA277002169	635	I>F		No	ClinGen Ensembl
rs1467317181 CA394580629	638	A>T		No	ClinGen gnomAD
rs750862551 CA7871524	638	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1361670996 CA394580623	639	P>S		No	ClinGen gnomAD
rs868204077 CA277002139	641	S>F		No	ClinGen Ensembl
CA277002137 rs973524248	642	E>D		No	ClinGen gnomAD
CA7871520 rs370853116	644	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs915966240 CA277002116	645	A>D		No	ClinGen gnomAD
CA7871518 rs752875724	645	A>T		No	ClinGen ExAC gnomAD
rs915966240 CA394580584	645	A>V		No	ClinGen gnomAD
rs774173598 CA7871515	646	E>D		No	ClinGen ExAC gnomAD
CA7871516 rs759674069	646	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7871513 rs200558073	647	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770692766 CA7871514	647	G>R		No	ClinGen ExAC gnomAD
rs773096560 CA7871512	648	G>E		No	ClinGen ExAC gnomAD
rs1475481446 CA394580567	649	A>P		No	ClinGen TOPMed
rs769302200 CA7871511	650	P>S		No	ClinGen ExAC TOPMed gnomAD
CA394580552 rs1255643254	651	Q>H		No	ClinGen gnomAD
CA7871510 rs146408573	651	Q>L		No	ClinGen ESP ExAC gnomAD
rs780559672 CA7871509	652	N>K		No	ClinGen ExAC TOPMed gnomAD
rs143999770 CA7871508	653	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871507 rs542893253	654	C>R		No	ClinGen 1000Genomes ExAC gnomAD
CA394580531 rs1245676303	655	Q>E		No	ClinGen gnomAD
rs1597151596 CA394580528	655	Q>P		No	ClinGen Ensembl
rs977346667 CA394580516	656	D>E		No	ClinGen TOPMed gnomAD
CA7871506 rs779440212	657	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1227383281 CA394580488	660	N>S		No	ClinGen TOPMed gnomAD
rs113187435 RCV000970887 CA7871504	661	S>G		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
TCGA novel	661	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394580327 rs1597150761	665	S>F		No	ClinGen Ensembl
rs76488354 CA277000749	666	G>*		No	ClinGen Ensembl
rs1378313214 CA394580317	667	G>E		No	ClinGen TOPMed
rs1160205554 CA394580321	667	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA7871457 rs780073586	668	P>R		No	ClinGen ExAC gnomAD
CA394580299 rs1173019018	670	P>H		No	ClinGen TOPMed
rs1452957344 CA394580302	670	P>T		No	ClinGen TOPMed
CA394580278 rs1386547859	673	Q>R		No	ClinGen gnomAD
CA7871455 rs750592510	674	N>D		No	ClinGen ExAC TOPMed gnomAD
rs112278827 CA7871454	674	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7871451 rs763995166	675	G>R		No	ClinGen ExAC TOPMed gnomAD
rs763995166 CA7871452	675	G>W		No	ClinGen ExAC TOPMed gnomAD
CA7871450 rs370068796	677	L>F		No	ClinGen ESP ExAC gnomAD
CA394580250 rs1253174135	678	S>N		No	ClinGen gnomAD
CA7871449 rs775180493	679	P>R		No	ClinGen ExAC gnomAD
TCGA novel	683	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868435762 CA277000641	686	T>I		No	ClinGen Ensembl
rs759286668 CA7871447	687	N>H		No	ClinGen ExAC TOPMed gnomAD
CA394580183 rs1245864546	688	S>G		No	ClinGen gnomAD
rs1400305269 CA394580169	689	Q>H		No	ClinGen gnomAD
rs1321369782 CA394580155	692	L>V		No	ClinGen gnomAD
rs770201418 CA7871445	694	E>G		No	ClinGen ExAC gnomAD
TCGA novel	694	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA277000620 rs866821182	697	Q>*		No	ClinGen Ensembl
rs866821182 CA394580122	697	Q>E		No	ClinGen Ensembl
CA277000612 rs961185232	697	Q>H		No	ClinGen Ensembl
CA394580119 rs1347782959	697	Q>R		No	ClinGen TOPMed
TCGA novel	698	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA394580073 rs1366944598	703	A>V		No	ClinGen gnomAD
rs1262012014 CA394580072	704	G>R		No	ClinGen TOPMed
CA277000575 rs1016884739	705	V>M		No	ClinGen Ensembl
rs1456924971 CA394580058	706	S>I		No	ClinGen gnomAD
CA394580056 rs1456924971	706	S>N		No	ClinGen gnomAD
rs1005470058 CA277000569 COSM1377878	710	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1235979588 CA394580021	712	L>V		No	ClinGen TOPMed
CA394580006 rs1482347441	714	P>L		No	ClinGen gnomAD
rs201116391 CA7871436	715	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs150564905 CA7871434	716	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs777620315 CA7871433	716	R>S		No	ClinGen ExAC TOPMed gnomAD
rs201439024 CA277000526	717	F>L		No	ClinGen Ensembl
rs1174337540 CA394579986	718	K>E		No	ClinGen TOPMed
TCGA novel	719	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7871431 rs752621995 COSM1678812	721	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs756178630 CA7871432	721	R>W		No	ClinGen ExAC gnomAD
CA7871430 rs767139105	722	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1347350747 CA394579941	724	T>M		No	ClinGen gnomAD
COSM1377877 rs142301454 CA277000488	725	D>Y	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP NCI-TCGA
rs1387880515 CA394579931	726	A>S		No	ClinGen gnomAD
CA394579933 rs1387880515	726	A>T		No	ClinGen gnomAD
CA394579910 rs1457412681	729	V>M		No	ClinGen TOPMed gnomAD
rs762632067 CA7871427	730	D>E		No	ClinGen ExAC TOPMed gnomAD
CA7871425 rs776923222	731	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1471789490 CA394579882	733	K>R		No	ClinGen gnomAD
rs1291221245 CA394579874	734	E>G		No	ClinGen TOPMed gnomAD
CA394579870 rs1597150543	735	D>N		No	ClinGen Ensembl
CA7871400 rs147236842	736	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA394579317 rs1393881621	738	M>I		No	ClinGen TOPMed
CA7871399 rs778100108	739	K>R		No	ClinGen ExAC gnomAD
rs769730820 CA7871398	742	F>L		No	ClinGen ExAC gnomAD
CA394579265 rs1389621551	743	F>L		No	ClinGen TOPMed gnomAD
CA7871397 rs748002012	745	P>L		No	ClinGen ExAC
TCGA novel	745	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1438401631 CA394579223	747	I>V		No	ClinGen TOPMed
rs746910984 CA7871394	748	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1567425939 CA394579187	750	F>C		No	ClinGen Ensembl
CA394579174 rs1229246853	751	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA276997928 COSM970633 rs1010017999	754	F>V	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs750100695 CA7871391	756	D>N		No	ClinGen ExAC gnomAD
rs143872089 CA7871390	757	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394579096 rs1195495074	758	E>G		No	ClinGen TOPMed
CA276997926 rs200493349	759	L>V		No	ClinGen Ensembl
rs1268282511 CA394579065	761	R>*		No	ClinGen TOPMed
rs1482479944 CA394579062	761	R>P		No	ClinGen gnomAD
rs1482479944 CA394579064	761	R>Q		No	ClinGen gnomAD
rs1597148485 CA394579051	762	S>F		No	ClinGen Ensembl
CA7871389 rs756874601	763	Y>C		No	ClinGen ExAC gnomAD
rs767854924 COSM340441 CA7871387	766	S>C	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA276997920 rs765982614	767	Y>C		No	ClinGen gnomAD
rs774854321 CA7871385	770	E>K		No	ClinGen ExAC TOPMed gnomAD
CA276991682 rs751329610	771	V>I		No	ClinGen Ensembl
rs760570249 CA394577993	772	I>K		No	ClinGen ExAC gnomAD
VAR_023750 CA7871359 rs2230739	772	I>M	found in 37.5% of the Asian population, in 30% of the Caucasian population and in 16.3% of the African-American population; reduced adenylyl cyclase activity in response to stimulation of the beta-adregnergic receptor by Mn(2+) agonists isoproteronol and NaF; increased albuterol-stimulated adenylyl cyclase activity in the presence of corticosteroid [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7871360 rs760570249	772	I>T		No	ClinGen ExAC gnomAD
CA7871361 rs768361177	772	I>V		No	ClinGen ExAC gnomAD
CA394577976 rs1438743877	774	N>K		No	ClinGen TOPMed gnomAD
rs1367661195 COSM1377875 CA394577970	775	S>F	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1434109826 CA394577968	776	P>A		No	ClinGen TOPMed gnomAD
rs1386171256 CA394577964	776	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs374735605 CA7871355	777	V>M		No	ClinGen ESP ExAC gnomAD
CA7871354 rs748969774	779	T>A		No	ClinGen ExAC gnomAD
CA394577946 rs1170328809	779	T>M		No	ClinGen gnomAD
CA394577928 rs1421051771	782	S>N		No	ClinGen TOPMed
CA394577916 rs1187522586	784	T>A		No	ClinGen gnomAD
CA394577906 rs1435893894	785	F>S		No	ClinGen TOPMed
rs1212916667 CA394577903	786	S>G		No	ClinGen gnomAD
CA394577898 rs1313318580	786	S>I		No	ClinGen TOPMed gnomAD
CA394577899 rs1313318580	786	S>T		No	ClinGen TOPMed gnomAD
CA276991655 rs922260415	787	S>F		No	ClinGen TOPMed gnomAD
CA394577888 rs1567422183	788	L>F		No	ClinGen Ensembl
rs759028302 CA7871350	790	D>H		No	ClinGen ExAC gnomAD
rs759028302 CA7871349	790	D>N		No	ClinGen ExAC gnomAD
rs759028302 CA394577879	790	D>Y		No	ClinGen ExAC gnomAD
rs1221654127 CA394577853	794	S>P		No	ClinGen TOPMed
CA394577854 rs1221654127	794	S>T		No	ClinGen TOPMed
CA394577834 rs1448423965	797	V>L		No	ClinGen TOPMed gnomAD
rs753842503 CA7871345	800	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1597143694 CA394577801	803	T>P		No	ClinGen Ensembl
CA394577789 rs1167617329	805	C>R		No	ClinGen gnomAD
rs1183996465 CA394577771	807	L>Q		No	ClinGen gnomAD
CA276991611 rs985777337	808	K>E		No	ClinGen Ensembl
rs1481740999 CA394577765	808	K>R		No	ClinGen TOPMed
CA7871341 rs201102758	809	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7871339 rs186527865	810	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs186527865 CA394577754	810	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394577747 rs1352626603	811	A>S		No	ClinGen TOPMed gnomAD
CA7871338 rs372048350	811	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1228010830 CA394577742	812	A>T		No	ClinGen gnomAD
rs1306009113 CA394577737	812	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs777113575 CA7871336	813	T>A		No	ClinGen ExAC gnomAD
rs777113575 CA394577735	813	T>P		No	ClinGen ExAC gnomAD
CA7871334 rs145223924	814	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7871333 rs145223924	814	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276991535 rs1002199492	816	P>H		No	ClinGen TOPMed
rs1002199492 CA394577719	816	P>R		No	ClinGen TOPMed
rs750993435 CA7871331	816	P>S		No	ClinGen ExAC gnomAD
CA7871330 rs367822989	817	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA394577706 rs764068928	819	A>P		No	ClinGen ExAC gnomAD
rs764068928 CA7871327	819	A>T		No	ClinGen ExAC gnomAD
rs752796119 CA394577701	820	A>S		No	ClinGen ExAC TOPMed gnomAD
rs752796119 CA7871325	820	A>T		No	ClinGen ExAC TOPMed gnomAD
rs767330823 CA7871324	820	A>V		No	ClinGen ExAC gnomAD
CA394577688 rs558610583	822	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7871323 rs558610583	822	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766342969 CA394577670	825	S>N		No	ClinGen ExAC gnomAD
rs766342969 CA7871321	825	S>T		No	ClinGen ExAC gnomAD
rs777128676 CA7871320	826	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1046996697 CA276991484	827	A>S		No	ClinGen TOPMed
rs1291186470 CA394577657	827	A>V		No	ClinGen gnomAD
rs929877484 CA276991474	830	L>M		No	ClinGen TOPMed gnomAD
CA394577646 rs929877484	830	L>V		No	ClinGen TOPMed gnomAD
rs922314244 CA276991450	831	E>*		No	ClinGen TOPMed gnomAD
rs922314244 CA394577642	831	E>Q		No	ClinGen TOPMed gnomAD
rs1597143538 CA394577630	832	V>G		No	ClinGen Ensembl
CA394577635 rs1293822996	832	V>M		No	ClinGen gnomAD
CA276991447 rs766810277	833	L>P		No	ClinGen TOPMed gnomAD
CA394577617 rs1459120707	835	L>F		No	ClinGen TOPMed gnomAD
CA394577611 rs1181701464	836	A>P		No	ClinGen TOPMed gnomAD
CA394577612 rs1181701464	836	A>T		No	ClinGen TOPMed gnomAD
CA394577608 rs1417470406	836	A>V		No	ClinGen TOPMed gnomAD
rs776102254 CA7871316	839	I>M		No	ClinGen ExAC
CA7871290 rs187903829	842	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA394576917 rs1186780237	843	F>Y		No	ClinGen TOPMed
rs900818550 CA276985268	845	L>V		No	ClinGen TOPMed gnomAD
CA394576869 rs1450302468	847	D>A		No	ClinGen gnomAD
rs375674603 CA7871287	848	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766162854 CA7871285	850	A>P		No	ClinGen ExAC gnomAD
CA394576820 rs758085762	851	C>F		No	ClinGen ExAC TOPMed gnomAD
CA7871284 rs758085762	851	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs750213995 CA276985220	854	R>C		No	ClinGen ExAC TOPMed gnomAD
rs750213995 CA7871283	854	R>G		No	ClinGen ExAC TOPMed gnomAD
CA7871282 rs142198070	854	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs142198070 CA7871281	854	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs760409676 CA7871278	858	W>C		No	ClinGen ExAC TOPMed gnomAD
rs1267974635 CA394576754	858	W>R		No	ClinGen TOPMed gnomAD
rs545216961 CA394576727	860	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs545216961 CA7871277	860	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7871275 rs763275318	861	G>S		No	ClinGen ExAC TOPMed gnomAD
CA394576702 rs1373761894	862	W>C		No	ClinGen gnomAD
CA276985163 rs1004277264	864	P>A		No	ClinGen Ensembl
rs773593169 CA394576681	865	R>C		No	ClinGen ExAC TOPMed gnomAD
rs770270080 CA7871273	865	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs773593169 CA7871274	865	R>S		No	ClinGen ExAC TOPMed gnomAD
rs910937151 CA276985147	866	H>L		No	ClinGen TOPMed
CA7871272 rs748638309	868	I>L		No	ClinGen ExAC gnomAD
rs1473692140 CA394576643	869	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	870	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747260152 CA7871269	871	I>L		No	ClinGen ExAC TOPMed gnomAD
CA394576602 rs149616013	873	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7871268 rs149616013	873	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA276985099 rs755239155	874	S>L		No	ClinGen TOPMed
rs1026739385 CA276985089	876	P>R		No	ClinGen Ensembl
rs144986362 COSM178844 CA7871265	877	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs145252548 CA276985070	877	A>V		No	ClinGen ESP TOPMed gnomAD
rs1290685591 CA394576540	879	A>V		No	ClinGen gnomAD
CA7871261 rs377240633	880	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA276985012 rs959451403	882	S>Y		No	ClinGen TOPMed
CA7871259 rs767115758	883	H>R		No	ClinGen ExAC TOPMed gnomAD
CA394576477 rs1303982675	885	T>I		No	ClinGen TOPMed
CA394576479 rs1567419574	885	T>S		No	ClinGen Ensembl
rs770135718 CA7871256	887	E>K		No	ClinGen ExAC TOPMed gnomAD
rs770135718 CA394576462	887	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA394576449 rs1182795178	888	Y>H		No	ClinGen gnomAD
rs372821407 CA7871255	891	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7871254 rs777080266	892	I>T		No	ClinGen ExAC gnomAD
CA394576403 rs1202549975	892	I>V		No	ClinGen TOPMed
rs768742360 CA7871253	893	H>N		No	ClinGen ExAC gnomAD
rs758044219	894	F>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1251094400 CA394576278	894	F>I		No	ClinGen TOPMed
CA7871217 rs550558850	896	V>G		No	ClinGen ExAC TOPMed gnomAD
CA276983638 rs764388635	896	V>L		No	ClinGen ExAC gnomAD
CA7871218 rs764388635	896	V>M		No	ClinGen ExAC gnomAD
CA394576244 rs1439383555	897	F>V		No	ClinGen TOPMed
rs776026141 CA7871216	898	T>A		No	ClinGen ExAC TOPMed gnomAD
CA7871214 rs759712460	898	T>I		No	ClinGen ExAC gnomAD
CA7871215 rs759712460	898	T>R		No	ClinGen ExAC gnomAD
rs1359591767 CA394576217	899	G>D		No	ClinGen gnomAD
rs771344306 COSM50420 CA7871212	900	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1597139296 CA394576198	901	A>V		No	ClinGen Ensembl
CA7871208 rs147280539	902	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7871206 rs147280539	902	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7871207 rs147280539	902	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs912752455 CA276983557	902	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs779529291 CA7871204	903	L>M		No	ClinGen ExAC gnomAD
rs1597139260 CA394576160	905	A>V		No	ClinGen Ensembl
rs150826321 CA276983540	906	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871202 rs150826321 COSM308948	906	V>I	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA7871200 rs756453051	907	V>M		No	ClinGen ExAC TOPMed gnomAD
CA394576118 rs905073122	909	Y>F		No	ClinGen TOPMed gnomAD
rs1457319401 CA394576122	909	Y>H		No	ClinGen TOPMed
CA276983522 rs905073122	909	Y>S		No	ClinGen TOPMed gnomAD
rs1045137938 CA276983518	910	C>R		No	ClinGen TOPMed gnomAD
CA394576113 rs1045137938	910	C>S		No	ClinGen TOPMed gnomAD
CA394576107 rs1252168727	910	C>Y		No	ClinGen TOPMed gnomAD
CA394576088 rs1204091731	912	F>I		No	ClinGen gnomAD
CA7871199 rs752983999	915	L>F		No	ClinGen ExAC gnomAD
CA394576017 rs1310659602	918	W>R		No	ClinGen gnomAD
CA7871197 rs759954267	920	R>K		No	ClinGen ExAC gnomAD
CA276983501 rs759954267	920	R>M		No	ClinGen ExAC gnomAD
rs1464029468 CA394575980	921	S>A		No	ClinGen TOPMed
CA394575976 rs1329834891	921	S>F		No	ClinGen TOPMed
rs751717694 CA7871196	923	L>F		No	ClinGen ExAC TOPMed gnomAD
rs763272036 CA394575953	924	A>S		No	ClinGen ExAC gnomAD
CA7871194 rs763272036	924	A>T		No	ClinGen ExAC gnomAD
CA394575928 rs1167591871	926	V>A		No	ClinGen gnomAD
CA7871190 rs776256089	926	V>I		No	ClinGen ExAC TOPMed gnomAD
CA394575924 rs779548082	927	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7871187 rs779548082	927	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs144319192 CA7871184	929	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7871182 rs753174574	930	G>A		No	ClinGen ExAC gnomAD
CA394575892 rs753174574	930	G>E		No	ClinGen ExAC gnomAD
CA394575897 rs1214446616	930	G>R		No	ClinGen TOPMed
rs374631917 CA7871181	931	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1190816780 CA394575868	933	L>P		No	ClinGen TOPMed
rs1262881841 CA394575852	935	L>F		No	ClinGen TOPMed
CA7871176 rs750505834	936	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1169192126 CA394575842	936	Y>D		No	ClinGen TOPMed
CA7871174 rs374209133	937	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1347599961 CA394575816	938	S>F		No	ClinGen TOPMed
CA7871172 rs768273214	939	L>P		No	ClinGen ExAC gnomAD
rs1176556124 CA394575791	941	P>A		No	ClinGen TOPMed gnomAD
rs1039087539 CA276983385	941	P>L		No	ClinGen TOPMed
rs200807161 CA7871143	945	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs780559235 CA7871141	947	T>A		No	ClinGen ExAC gnomAD
CA394574799 rs758989525	947	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7871140 rs758989525	947	T>S		No	ClinGen ExAC gnomAD
COSM970628 CA7871138 rs779084996	948	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1044390225 CA276981212	949	P>A		No	ClinGen gnomAD
TCGA novel	950	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756325728 CA7871134	952	A>T		No	ClinGen ExAC gnomAD
CA394574768 rs950171987	953	V>I		No	ClinGen TOPMed gnomAD
rs950171987 CA276981192	953	V>L		No	ClinGen TOPMed gnomAD
rs1434141802 CA394574761	954	Q>K		No	ClinGen TOPMed gnomAD
TCGA novel	956	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7871108 rs764775577	959	E>K		No	ClinGen ExAC TOPMed gnomAD
rs974015341 CA276975995	961	N>D		No	ClinGen TOPMed
CA7871106 rs768405098	962	P>L	Variant assessed as Somatic; 4.646e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7871105 rs768405098	962	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA7871103 rs774774591	963	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA394574675 rs1258513412	964	N>D		No	ClinGen Ensembl
rs771400616 CA7871102	964	N>S		No	ClinGen ExAC gnomAD
CA394574668 rs1335425544	965	S>G		No	ClinGen gnomAD
rs1042273291 CA276975981	965	S>I		No	ClinGen TOPMed gnomAD
CA7871100 COSM970627 rs777717895	966	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA7871098 rs748391119	967	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7871096 rs184286992	968	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368342558 CA7871097	968	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs545959256 CA7871094	969	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7871092 rs141519764	969	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141519764 CA7871093	969	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1027823367 CA276975936	970	D>A		No	ClinGen Ensembl
rs893651633 CA276975933	971	L>F		No	ClinGen TOPMed
rs1470161574 CA394574635	971	L>P		No	ClinGen gnomAD
rs200143861 CA394574633	972	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs374135203 CA276975916	972	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs374135203 COSM178841 CA7871090	972	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs200143861 CA7871091	972	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763906715 CA7871088	973	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7871089 rs200825289	973	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs774593490 CA7871086	975	A>P		No	ClinGen ExAC gnomAD
rs774593490 CA276975872	975	A>T		No	ClinGen ExAC gnomAD
rs1401024401 CA394574617	976	S>G		No	ClinGen TOPMed gnomAD
rs1236756658 CA394574613	976	S>I		No	ClinGen gnomAD
CA394574609 rs1371929686	977	L>V		No	ClinGen TOPMed gnomAD
rs763398960 CA7871085	978	I>M		No	ClinGen ExAC TOPMed gnomAD
rs770263456 CA7871082	979	G>R		No	ClinGen ExAC TOPMed gnomAD
CA7871083 rs770263456	979	G>S		No	ClinGen ExAC TOPMed gnomAD
CA7871080 rs776685050	980	Q>E		No	ClinGen ExAC gnomAD
rs768815007 CA394574591	980	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs768815007 CA7871079	980	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA394574575 rs1175185834	982	V>G		No	ClinGen gnomAD
CA394574561 rs745631015	985	V>F		No	ClinGen ExAC TOPMed gnomAD
CA7871075 rs745631015	985	V>I		No	ClinGen ExAC TOPMed gnomAD
rs745631015 CA394574562 COSM1629894	985	V>L	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs779038291 CA7871072	988	L>I		No	ClinGen ExAC TOPMed gnomAD
rs779038291 CA394574541	988	L>V		No	ClinGen ExAC TOPMed gnomAD
rs755728965 CA7871068	992	L>F		No	ClinGen ExAC gnomAD
CA394574517 rs763640707	992	L>V		No	ClinGen ExAC TOPMed gnomAD
CA394574507 rs1246814546	993	V>G		No	ClinGen TOPMed
rs1348910075 CA394574497	995	F>I		No	ClinGen gnomAD
rs752352941 CA7871066	995	F>L		No	ClinGen ExAC gnomAD
rs1467181138 CA394574475	998	R>C		No	ClinGen TOPMed
rs372256275 CA7871065	998	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs773530497 CA7871063	999	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7871062 rs765800358	1004	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA394574432 rs765800358	1004	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs762293576 CA7871061	1005	R>C		No	ClinGen ExAC gnomAD
CA7871060 rs776703788	1005	R>H		No	ClinGen ExAC gnomAD
rs1374494955 CA394574421	1006	L>H		No	ClinGen gnomAD
rs1171333142 CA394574416	1007	H>Y		No	ClinGen gnomAD
rs768712325 CA7871059	1009	H>D		No	ClinGen ExAC TOPMed gnomAD
rs1422083472 CA394574399	1009	H>R		No	ClinGen gnomAD
CA276975794 rs369874673	1011	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA394574381 rs1415087301	1012	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1257126554 CA394574357	1015	D>E		No	ClinGen gnomAD
rs961414699 CA276975770	1015	D>G		No	ClinGen gnomAD
rs1208276083 CA394574350	1016	L>R		No	ClinGen gnomAD
rs72556389 CA276975760	1017	H>L		No	ClinGen Ensembl
rs954982548 CA276975766	1017	H>Y		No	ClinGen TOPMed gnomAD
rs772154703 CA7871056	1018	R>H		No	ClinGen ExAC gnomAD
CA7871055 rs745725605	1019	T>A		No	ClinGen ExAC gnomAD
CA7871054 rs778842205	1020	K>N		No	ClinGen ExAC gnomAD
CA394574330 rs1316019716	1020	K>T		No	ClinGen gnomAD
rs757277884 CA7871053	1022	Q>E		No	ClinGen ExAC gnomAD
rs749173620 CA7871052	1024	M>I		No	ClinGen ExAC gnomAD
rs777459326 CA394574296	1025	R>G		No	ClinGen ExAC gnomAD
CA7871050 rs537762832	1025	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	1025	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1428143466 CA394574269	1029	D>H		No	ClinGen TOPMed
rs767235806 CA7871048	1030	W>R		No	ClinGen ExAC gnomAD
CA394574195 CA394574194 rs375586019	1039	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1040	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1422168562 CA394574182	1041	A>V		No	ClinGen gnomAD
CA394574133 rs1167697653	1048	Q>H		No	ClinGen gnomAD
rs750845309 CA7871046	1049	T>I		No	ClinGen ExAC gnomAD
rs762310025 CA7871044	1051	S>P		No	ClinGen ExAC
CA394574110 rs1180128663	1052	K>R		No	ClinGen gnomAD
rs2230742 CA7871043 CA394574092	1054	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394574088 rs1234569494	1055	D>G		No	ClinGen TOPMed gnomAD
CA276975732 rs964742894	1055	D>H		No	ClinGen TOPMed gnomAD
CA394574090 rs964742894	1055	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA394574087 rs1234569494	1055	D>V		No	ClinGen TOPMed gnomAD
CA394574091 rs964742894	1055	D>Y		No	ClinGen TOPMed gnomAD
COSM1678811 rs760849601 CA7871041	1057	G>R	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA394574060 rs1597132015	1059	V>G		No	ClinGen Ensembl
CA7871040 rs775427887	1060	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1315704361 CA394574052	1061	F>L		No	ClinGen gnomAD
rs72556390 CA394574044	1062	A>S		No	ClinGen TOPMed gnomAD
rs72556390 CA276975722	1062	A>T	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7871038 rs759778264	1063	S>N		No	ClinGen ExAC gnomAD
rs566557148 CA394574033	1064	I>L		No	ClinGen 1000Genomes ExAC gnomAD
rs566557148 CA7871037	1064	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA7871034 rs777812556	1065	V>A		No	ClinGen ExAC gnomAD
rs1297229961 CA394574027	1065	V>I		No	ClinGen TOPMed gnomAD
rs1297229961 CA394574026	1065	V>L		No	ClinGen TOPMed gnomAD
CA394574018 rs1359571796	1066	N>S		No	ClinGen TOPMed
rs146567172 CA7871033	1068	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA7871032 rs151019592	1068	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs959631555 CA276975671	1069	E>A		No	ClinGen Ensembl
rs552555768 CA276975674	1069	E>K		No	ClinGen Ensembl
rs1162803356 CA394573978	1072	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA394573977 rs1162803356	1072	E>Q		No	ClinGen TOPMed gnomAD
rs779278647 CA7871028	1076	E>K		No	ClinGen ExAC gnomAD
rs757669826 CA7871027	1077	G>V		No	ClinGen ExAC gnomAD
CA7871025 rs371807206	1078	G>S		No	ClinGen ESP ExAC gnomAD
rs1222332240 CA394573925	1079	K>R		No	ClinGen TOPMed
rs759871885 CA394573896	1083	R>P		No	ClinGen ExAC TOPMed
CA7871021 rs759871885	1083	R>Q		No	ClinGen ExAC TOPMed
rs767432735 CA7871022	1083	R>W		No	ClinGen ExAC gnomAD
rs1237487191 CA394573887	1085	L>F		No	ClinGen gnomAD
rs762878876 CA7871018	1089	I>V		No	ClinGen ExAC gnomAD
rs1395101421 CA394573831	1093	D>H		No	ClinGen TOPMed gnomAD
TCGA novel	1093	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780756690 CA7871014	1096	L>V		No	ClinGen ExAC gnomAD
rs768112417 CA7871013	1097	S>N		No	ClinGen ExAC gnomAD
rs1397079174 CA394573787	1099	P>L		No	ClinGen gnomAD
CA7871012 rs531124205	1099	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed
rs754286793 CA7871009	1100	D>A		No	ClinGen ExAC
rs758042130 CA7871010	1100	D>Y		No	ClinGen ExAC gnomAD
CA394573779 rs1265231936	1101	Y>H		No	ClinGen gnomAD
CA394573772 rs1434488549	1102	S>G		No	ClinGen TOPMed
CA7871007 rs756652210	1102	S>R		No	ClinGen ExAC TOPMed gnomAD
CA7871006 rs548468725	1103	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA7871004 rs759735634	1104	I>M		No	ClinGen ExAC TOPMed gnomAD
CA394573754 rs1213738293	1104	I>T		No	ClinGen gnomAD
TCGA novel	1109	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1445327990 CA394573708 COSM1742714	1111	G>R	biliary_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
CA394573691 rs1299897624	1113	T>M		No	ClinGen TOPMed gnomAD
CA7871000 rs773073326	1116	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA394573663 rs1417890063	1117	A>V		No	ClinGen gnomAD
CA7870996 rs576787672	1121	N>S		No	ClinGen 1000Genomes ExAC gnomAD
CA394573638 rs1597131810	1122	T>P		No	ClinGen Ensembl
CA7870993 COSM3402320 rs771725261	1123	A>T	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7870992 rs745449501 COSM3794847	1123	A>V	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA7870990 rs756388353	1124	Q>E		No	ClinGen ExAC gnomAD
CA276975481 rs940194040	1124	Q>R		No	ClinGen Ensembl
CA7870989 rs544468394	1125	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7870988 rs374305565	1125	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs751743531 CA7870986	1126	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA276975475 rs776446870	1127	D>G		No	ClinGen Ensembl
CA394573611 rs1230026025	1127	D>N		No	ClinGen gnomAD
rs750569843 CA7870983	1128	G>D		No	ClinGen ExAC
CA394573604 rs1278100124	1128	G>S		No	ClinGen TOPMed gnomAD
rs1357446146 CA394573582	1131	P>A		No	ClinGen gnomAD
rs201367484 CA7870982	1131	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs776481614 CA7870980	1132	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA276975444 rs551293106	1135	L>V		No	ClinGen Ensembl
CA394573550 rs1422886469	1136	Q>*		No	ClinGen gnomAD
rs1168406570 CA394573545	1136	Q>H		No	ClinGen gnomAD
rs1417323161 CA394573547	1136	Q>R		No	ClinGen TOPMed
rs1475939275 CA394573537	1137	I>M		No	ClinGen gnomAD
rs774989006 CA7870977	1138	L>V		No	ClinGen ExAC gnomAD
COSM231718 rs745559844 CA7870975	1140	E>K	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA394573508 rs770583603	1142	A>S		No	ClinGen ExAC TOPMed gnomAD
CA7870973 rs770583603	1142	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7870972 rs748524658	1145	M>V		No	ClinGen ExAC TOPMed gnomAD
CA7870971 rs781677508	1146	M>T		No	ClinGen ExAC TOPMed gnomAD
rs755552694 CA7870970	1147	R>C		No	ClinGen ExAC gnomAD
rs755552694 CA394573471	1147	R>G		No	ClinGen ExAC gnomAD
rs145693515 CA7870969	1147	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs145693515 CA394573470	1147	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1338947684 CA394573468	1148	V>M		No	ClinGen TOPMed gnomAD
CA7870968 rs780311928	1150	D>N		No	ClinGen ExAC gnomAD
CA7870966 rs750492924	1151	D>N		No	ClinGen ExAC gnomAD
CA276975363 rs61731445	1154	N>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61731445 CA7870965 VAR_070887	1154	N>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs757489326 CA7870964	1155	N>D		No	ClinGen ExAC gnomAD
CA394573403 rs1365225812	1157	L>Q		No	ClinGen gnomAD
CA7870962 rs763810376	1158	W>S		No	ClinGen ExAC gnomAD
rs752586436 CA7870961	1160	N>K		No	ClinGen ExAC gnomAD
rs1197068652 CA394573364	1162	K>R		No	ClinGen gnomAD
rs1195076485 CA394573353	1164	R>C		No	ClinGen TOPMed
CA394573351 COSM3817969 rs1421885899	1164	R>H	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs144864117 CA7870957	1165	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394573349 rs144864117	1165	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7870954 rs777136439	1168	N>S		No	ClinGen ExAC gnomAD
rs940309439 CA276975279	1169	H>R		No	ClinGen Ensembl
CA7870951 rs780753391	1171	P>A		No	ClinGen ExAC TOPMed gnomAD
rs780753391 CA394573310	1171	P>S		No	ClinGen ExAC TOPMed gnomAD
COSM1377869 rs1371707087 CA394573294	1173	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1403167221 CA394573288	1174	A>V		No	ClinGen gnomAD
rs1158584676 CA394573287	1175	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA394573277 rs1597131570	1176	V>G		No	ClinGen Ensembl
rs757425450 CA7870947	1176	V>I		No	ClinGen ExAC gnomAD
CA394573275 rs1567412866	1177	I>V		No	ClinGen Ensembl
CA7870945 rs777570578	1178	G>S		No	ClinGen ExAC TOPMed gnomAD
rs775005712 CA276975237	1181	K>E		No	ClinGen Ensembl
rs1206521304 CA394573227	1185	D>N		No	ClinGen TOPMed
CA7870940 rs751041166	1189	D>H		No	ClinGen ExAC gnomAD
rs1368036635 CA394573185	1190	T>I		No	ClinGen gnomAD
rs772950125 CA7870937	1193	I>T		No	ClinGen ExAC gnomAD
CA7870936 rs769546776	1194	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	1198	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA276975178 rs267604541	1201	G>D		No	ClinGen gnomAD
COSM435241 rs149465612 CA7870933	1201	G>S	Variant assessed as Somatic; 0.0001386 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs778892072 CA7870931	1202	V>M		No	ClinGen ExAC TOPMed gnomAD
rs770998158 CA7870930	1204	C>Y		No	ClinGen ExAC gnomAD
CA7870929 rs749352306 COSM1128959	1205	R>C	prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA7870928 rs778012664	1205	R>H		No	ClinGen ExAC gnomAD
CA394573078 rs1160493612	1206	I>M		No	ClinGen TOPMed
TCGA novel	1206	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747992457 CA7870926	1207	Q>*		No	ClinGen ExAC gnomAD
rs1567412764 CA394573074	1207	Q>R		No	ClinGen Ensembl
CA394573057 rs754871847	1209	S>R		No	ClinGen ExAC TOPMed gnomAD
CA276975155 rs770070508	1210	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1341412380 CA394573042	1211	E>D		No	ClinGen gnomAD
rs914794233 CA276975154	1213	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs914794233 CA394573029	1213	Y>F		No	ClinGen TOPMed
rs1278739094 CA394573024	1214	R>C		No	ClinGen TOPMed gnomAD
CA7870923 rs200863972	1214	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA7870919 rs765047478	1215	V>A		No	ClinGen ExAC gnomAD
rs369920383 CA7870921 COSM1182055	1215	V>I	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs369920383 CA7870920	1215	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394573000 rs1282118320	1218	K>T		No	ClinGen TOPMed
rs981533550 CA276975122	1219	M>I		No	ClinGen TOPMed gnomAD
rs761501337 CA394572992	1219	M>K		No	ClinGen ExAC TOPMed gnomAD
CA7870918 rs761501337	1219	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1219	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201893525 CA7870917	1220	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA276975117 rs971860689	1221	Y>C		No	ClinGen TOPMed
CA7870916 rs767884304	1224	D>A		No	ClinGen ExAC gnomAD
CA394572960 rs1477572085	1224	D>N		No	ClinGen gnomAD
TCGA novel	1227	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7870914 rs141452008	1229	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs559533290 CA7870913	1230	N>H		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	1230	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1362306134 CA394572876	1236	Q>P		No	ClinGen TOPMed
TCGA novel	1236	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773264079 CA7870911	1237	M>V		No	ClinGen ExAC gnomAD
CA394572853 rs1315921662	1239	T>N		No	ClinGen gnomAD
rs1294598242 CA394572850	1240	Y>N		No	ClinGen gnomAD
rs748299013 CA7870909	1244	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA7870908 rs147811130	1246	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA394572792 rs1465567691	1248	H>P		No	ClinGen gnomAD
rs746758399 CA7870906	1249	R>T		No	ClinGen ExAC gnomAD
CA276975095 rs1007408384	1250	V>F		No	ClinGen TOPMed gnomAD
CA394572765 rs780077845	1252	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7870905 rs780077845	1252	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs202245497 CA276975092 CA394572758	1253	Q>H		No	ClinGen 1000Genomes TOPMed
rs1597131338 CA394572759	1253	Q>L		No	ClinGen Ensembl
rs1413392573 CA394572753	1254	H>R		No	ClinGen gnomAD
rs758404652 CA7870904	1255	Q>R		No	ClinGen ExAC
rs764775400 CA7870902	1256	L>P		No	ClinGen ExAC gnomAD
rs753481552 CA394572729	1258	I>N		No	ClinGen ExAC gnomAD
rs753481552 CA7870900	1258	I>S		No	ClinGen ExAC gnomAD
CA394572731 rs1334815418	1258	I>V		No	ClinGen TOPMed
CA7870899 rs376614156	1259	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7870897 rs774577020	1261	D>H		No	ClinGen ExAC gnomAD
rs766932381 CA7870896	1261	D>V		No	ClinGen ExAC gnomAD
CA7870895 rs763389710	1263	R>C		No	ClinGen ExAC TOPMed gnomAD
rs773282474 CA7870894	1263	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7870892 rs151282873	1264	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7870891 rs367911334	1265	Q>H		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA7870890 rs768729134	1267	D>G		No	ClinGen ExAC gnomAD
CA394572673 rs1162694496	1268	G>S		No	ClinGen TOPMed gnomAD
rs1421753893 CA394572664	1269	S>N		No	ClinGen gnomAD
CA394572654 rs1177794562	1270	I>M		No	ClinGen gnomAD
rs538118003 CA276975021	1270	I>T		No	ClinGen TOPMed
rs746886527 CA7870889	1271	G>R		No	ClinGen ExAC gnomAD
rs997238587 CA276975011	1272	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs371680928 CA7870888	1272	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA276974998 rs897486098	1274	P>A		No	ClinGen Ensembl
rs778588883 CA7870886	1277	E>D		No	ClinGen ExAC gnomAD
rs1374162032 CA394572566	1278	I>M		No	ClinGen TOPMed
CA394572579 rs1567412547	1278	I>T		No	ClinGen Ensembl
rs142260607 CA276974963	1278	I>V		No	ClinGen ESP
CA394572552 rs1463925971	1279	A>D		No	ClinGen TOPMed
CA7870882 rs375515956	1282	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	1285	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370863551 CA276974947	1286	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs943523654 CA276974946	1287	Y>C		No	ClinGen TOPMed
rs763480855 CA7870877	1287	Y>H		No	ClinGen ExAC gnomAD
CA7870876 rs750878205	1289	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1439924451 CA394572387	1289	D>N		No	ClinGen TOPMed
CA7870875 rs530150534	1293	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA394572309 rs776569230	1294	G>C		No	ClinGen ExAC TOPMed gnomAD
rs776569230 CA7870873	1294	G>S		No	ClinGen ExAC TOPMed gnomAD
CA394572290 rs768979927	1295	S>C		No	ClinGen ExAC gnomAD
rs768979927 CA7870872	1295	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA394572263 rs1417697017	1296	D>E		No	ClinGen TOPMed gnomAD
CA276974909 rs888717225	1297	S>G		No	ClinGen TOPMed
rs148729420 CA7870871	1297	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs192788160 CA7870870	1299	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs192788160 CA394572209	1299	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368305972 CA7870867	1300	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs770771235 CA7870866	1301	A>S		No	ClinGen ExAC gnomAD
CA7870865 rs748891359	1302	K>M		No	ClinGen ExAC gnomAD
TCGA novel	1302	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7870863 rs777093117	1303	D>E		No	ClinGen ExAC gnomAD
rs1486414978 CA394572125	1304	A>G		No	ClinGen TOPMed gnomAD
rs755792053 CA394572117 CA7870862	1305	H>Q		No	ClinGen ExAC TOPMed
rs1258134193 CA394572119	1305	H>R		No	ClinGen gnomAD
CA7870860 rs752248079	1307	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1461540677 CA394572102	1308	P>R		No	ClinGen TOPMed
rs1299789359 CA394572088	1310	R>I		No	ClinGen gnomAD
rs144464713 CA7870857	1311	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144464713 CA394572083	1311	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201541852 CA7870858	1311	P>T		No	ClinGen ExAC TOPMed gnomAD
rs913886418 CA276974828	1313	K>Q		No	ClinGen Ensembl
rs545884748 CA7870854	1314	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA394572058 rs915968908	1315	P>A		No	ClinGen TOPMed gnomAD
TCGA novel	1315	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs915968908 CA276974805	1315	P>T		No	ClinGen TOPMed gnomAD
rs1597131046 CA394572051	1316	V>A		No	ClinGen Ensembl
TCGA novel	1316	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764041960 CA7870852	1316	V>I		No	ClinGen ExAC TOPMed gnomAD
CA7870851 rs760974192	1318	A>T		No	ClinGen ExAC
CA7870849 rs146352467	1319	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1422302651 CA394572020	1321	R>G		No	ClinGen gnomAD
CA7870848 rs759474569	1321	R>K		No	ClinGen ExAC TOPMed
CA7870847 rs774279006	1322	G>D		No	ClinGen ExAC gnomAD
CA394572010 rs774279006	1322	G>V		No	ClinGen ExAC gnomAD
TCGA novel	1322	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1256363458 CA394572008 COSM970620	1323	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA394572007 rs149834476	1323	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7870846 rs149834476	1323	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA394571986 rs1261735077	1326	K>I		No	ClinGen TOPMed
CA7870845 rs749110041	1327	A>T		No	ClinGen ExAC TOPMed gnomAD
rs557051514 CA7870843	1329	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs772806621 CA7870844	1329	E>K		No	ClinGen ExAC TOPMed gnomAD
CA276974758 rs997578740	1330	K>Q		No	ClinGen TOPMed
rs780861346 CA394571952	1331	D>E		No	ClinGen ExAC gnomAD
rs754619679 CA7870839	1332	D>N		No	ClinGen ExAC TOPMed gnomAD
rs754619679 CA394571949	1332	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA394571931 rs1415016352	1334	D>G		No	ClinGen TOPMed
CA7870837 rs199644950	1335	E>G		No	ClinGen ExAC TOPMed gnomAD
CA276974751 COSM3420986 rs374081146	1335	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed gnomAD
CA394571927 rs374081146	1335	E>Q		No	ClinGen ESP TOPMed gnomAD
CA276974739 rs371323934	1338	I>T		No	ClinGen Ensembl
CA7870836 rs757814677	1340	E>A		No	ClinGen ExAC gnomAD
CA394571894 rs1402943117	1340	E>K		No	ClinGen gnomAD
rs1451398810 CA394571883	1341	A>V		No	ClinGen TOPMed
CA394571881 rs1411075318	1342	N>H		No	ClinGen gnomAD
rs139504822 CA7870833 CA394571876	1342	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1167942428 CA394571878	1342	N>S		No	ClinGen gnomAD
CA394571873 COSM1478870 rs1368722853	1343	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA7870832 rs752822315	1345	T>I		No	ClinGen ExAC TOPMed gnomAD
CA394571857 rs752822315	1345	T>S		No	ClinGen ExAC TOPMed gnomAD
CA7870831 rs767912207	1346	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs1214106113 CA394571847	1347	L>F		No	ClinGen TOPMed
rs200722281 CA7870829	1348	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200722281 CA394571840	1348	N>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1458627244 CA394571834	1349	V>A		No	ClinGen gnomAD
rs141625716 CA7870826	1349	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA7870827 rs141625716	1349	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA394571810 rs1194194706	1351	K>T		No	ClinGen gnomAD
CA276974664 rs1030612865	1352	S>G		No	ClinGen Ensembl
rs747722293 CA7870824	1352	S>N		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with O60503

2 regional properties for O60503

Type	Name	Position	InterPro Accession
domain	Histone deacetylase complex subunit SAP30 zinc-finger	18 - 88	IPR025717
domain	Histone deacetylase complex subunit SAP30, Sin3 binding domain	105 - 157	IPR025718

Functions

		Description
EC Number	4.6.1.1	Phosphorus-oxygen lyases
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
adenylate cyclase activity	Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.

6 GO annotations of biological process

Name	Definition
adenylate cyclase-activating adrenergic receptor signaling pathway	An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process.
adenylate cyclase-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
cAMP biosynthetic process	The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
in utero embryonic development	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P40145	ADCY8	Adenylate cyclase type 8	Homo sapiens (Human)	PR
P51830	Adcy9	Adenylate cyclase type 9	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MASPPHQQLL	HHHSTEVSCD	SSGDSNSVRV	KINPKQLSSN	SHPKHCKYSI	SSSCSSSGDS
70	80	90	100	110	120
GGVPRRVGGG	GRLRRQKKLP	QLFERASSRW	WDPKFDSVNL	EEACLERCFP	QTQRRFRYAL
130	140	150	160	170	180
FYIGFACLLW	SIYFAVHMRS	RLIVMVAPAL	CFLLVCVGFF	LFTFTKLYAR	HYAWTSLALT
190	200	210	220	230	240
LLVFALTLAA	QFQVLTPVSG	RGDSSNLTAT	ARPTDTCLSQ	VGSFSMCIEV	LFLLYTVMHL
250	260	270	280	290	300
PLYLSLCLGV	AYSVLFETFG	YHFRDEACFP	SPGAGALHWE	LLSRGLLHGC	IHAIGVHLFV
310	320	330	340	350	360
MSQVRSRSTF	LKVGQSIMHG	KDLEVEKALK	ERMIHSVMPR	IIADDLMKQG	DEESENSVKR
370	380	390	400	410	420
HATSSPKNRK	KKSSIQKAPI	AFRPFKMQQI	EEVSILFADI	VGFTKMSANK	SAHALVGLLN
430	440	450	460	470	480
DLFGRFDRLC	EETKCEKIST	LGDCYYCVAG	CPEPRADHAY	CCIEMGLGMI	KAIEQFCQEK
490	500	510	520	530	540
KEMVNMRVGV	HTGTVLCGIL	GMRRFKFDVW	SNDVNLANLM	EQLGVAGKVH	ISEATAKYLD
550	560	570	580	590	600
DRYEMEDGKV	IERLGQSVVA	DQLKGLKTYL	ISGQRAKESR	CSCAEALLSG	FEVIDGSQVS
610	620	630	640	650	660
SGPRGQGTAS	SGNVSDLAQT	VKTFDNLKTC	PSCGITFAPK	SEAGAEGGAP	QNGCQDEHKN
670	680	690	700	710	720
STKASGGPNP	KTQNGLLSPP	QEEKLTNSQT	SLCEILQEKG	RWAGVSLDQS	ALLPLRFKNI
730	740	750	760	770	780
REKTDAHFVD	VIKEDSLMKD	YFFKPPINQF	SLNFLDQELE	RSYRTSYQEE	VIKNSPVKTF
790	800	810	820	830	840
ASPTFSSLLD	VFLSTTVFLT	LSTTCFLKYE	AATVPPPPAA	LAVFSAALLL	EVLSLAVSIR
850	860	870	880	890	900
MVFFLEDVMA	CTKRLLEWIA	GWLPRHCIGA	ILVSLPALAV	YSHVTSEYET	NIHFPVFTGS
910	920	930	940	950	960
AALIAVVHYC	NFCQLSSWMR	SSLATVVGAG	PLLLLYVSLC	PDSSVLTSPL	DAVQNFSSER
970	980	990	1000	1010	1020
NPCNSSVPRD	LRRPASLIGQ	EVVLVFFLLL	LLVWFLNREF	EVSYRLHYHG	DVEADLHRTK
1030	1040	1050	1060	1070	1080
IQSMRDQADW	LLRNIIPYHV	AEQLKVSQTY	SKNHDSGGVI	FASIVNFSEF	YEENYEGGKE
1090	1100	1110	1120	1130	1140
CYRVLNELIG	DFDELLSKPD	YSSIEKIKTI	GATYMAASGL	NTAQAQDGSH	PQEHLQILFE
1150	1160	1170	1180	1190	1200
FAKEMMRVVD	DFNNNMLWFN	FKLRVGFNHG	PLTAGVIGTT	KLLYDIWGDT	VNIASRMDTT
1210	1220	1230	1240	1250	1260
GVECRIQVSE	ESYRVLSKMG	YDFDYRGTVN	VKGKGQMKTY	LYPKCTDHRV	IPQHQLSISP
1270	1280	1290	1300	1310	1320
DIRVQVDGSI	GRSPTDEIAN	LVPSVQYVDK	TSLGSDSSTQ	AKDAHLSPKR	PWKEPVKAEE
1330	1340	1350
RGRFGKAIEK	DDCDETGIEE	ANELTKLNVS	KSV