P51122
Gene name |
ANP32A (LANP, PHAP1) |
Protein name |
Acidic leucine-rich nuclear phosphoprotein 32 family member A |
Names |
Leucine-rich acidic nuclear protein , LANP , Potent heat-stable protein phosphatase 2A inhibitor I1PP2A |
Species |
Homo sapiens (Human) |
KEGG Pathway |
bta:538427 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
1-163 (Leucine-rich region) |
Relief mechanism |
PTM, Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51122
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51122-F1 | Predicted | AlphaFoldDB |
35 variants for P51122
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs461060701 | 3 | M>V | No | EVA | |
| rs460443512 | 15 | T>M | No | EVA | |
| rs444639379 | 19 | V>A | No | EVA | |
| rs440393124 | 95 | L>* | No | EVA | |
| rs482114535 | 115 | L>P | No | EVA | |
| rs463734465 | 132 | R>G | No | EVA | |
| rs441945556 | 144 | Y>* | No | EVA | |
| rs469107192 | 147 | G>R | No | EVA | |
| rs474844393 | 163 | Y>* | No | EVA | |
| rs459701412 | 166 | G>D | No | EVA | |
| rs441471952 | 170 | D>E | No | EVA | |
| rs471273119 | 174 | E>G | No | EVA | |
| rs437432670 | 176 | E>Q | No | EVA | |
| rs460769408 | 179 | Y>N | No | EVA | |
| rs438455722 | 186 | V>A | No | EVA | |
| rs455932208 | 187 | E>K | No | EVA | |
| rs444036052 | 191 | D>G | No | EVA | |
| rs455510487 | 192 | E>D | No | EVA | |
| rs473899343 | 192 | E>G | No | EVA | |
| rs800157964 | 195 | E>G | No | EVA | |
| rs466702051 | 196 | E>D | No | EVA | |
| rs433888224 | 196 | E>K | No | EVA | |
| rs451485202 | 197 | E>G | No | EVA | |
| rs465506019 | 199 | E>G | No | EVA | |
| rs450104398 | 201 | E>G | No | EVA | |
| rs468052731 | 202 | D>A | No | EVA | |
| rs468052731 | 202 | D>G | No | EVA | |
| rs438032035 | 202 | D>N | No | EVA | |
| rs449568965 | 203 | V>G | No | EVA | |
| rs479380436 | 204 | S>R | No | EVA | |
| rs460650380 | 205 | G>A | No | EVA | |
| rs477944062 | 208 | E>Q | No | EVA | |
| rs458593681 | 209 | E>G | No | EVA | |
| rs442031865 | 240 | E>D | No | EVA | |
| rs475335530 | 245 | G>A | No | EVA |
No associated diseases with P51122
1 regional properties for P51122
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, RING-type | 123 - 166 | IPR001841 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| nucleocytoplasmic transport | The directed movement of molecules between the nucleus and the cytoplasm. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZC6 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Bos taurus (Bovine) | SS |
| Q5F4A3 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Gallus gallus (Chicken) | SS |
| Q5ZMN0 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Gallus gallus (Chicken) | SS |
| Q8HY67 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| Q9V895 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Drosophila melanogaster (Fruit fly) | SS |
| Q92688 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Homo sapiens (Human) | SS |
| Q9BTT0 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Homo sapiens (Human) | SS |
| P39687 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Homo sapiens (Human) | EV |
| O43423 | ANP32CP | Putative uncharacterized protein ANP32CP | Homo sapiens (Human) | SS |
| P97822 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Mus musculus (Mouse) | SS |
| Q9EST5 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Mus musculus (Mouse) | SS |
| O35381 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Mus musculus (Mouse) | SS |
| Q9EST6 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Rattus norvegicus (Rat) | SS |
| Q5XIE0 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Rattus norvegicus (Rat) | SS |
| P49911 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Rattus norvegicus (Rat) | SS |
| Q7Y180 | Os03g0668900 | Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q9SCQ7 | At3g50690 | Acidic leucine-rich nuclear phosphoprotein 32-related protein | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6P1U7 | anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6NUW5 | anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7ZUP0 | anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMTVDFEEC | LKDSPRFRAA | LEEVEGDVAE | LELKLDKLVK | LCIAMIDTGK | AFCVANKQFM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGIRDLAQYS | SNDAVVETSL | TKFSDSLQEM | INFHTILFDQ | TQRSIKAQLQ | NFVKEDLRKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDAKKQFEKV | SEEKENALVK | NAQVQRNKQH | EVEEATNILT | ATRKCFRHIA | LDYVLQINVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSKRRSEILK | SMLSFMYAHL | AFFHQGYDLF | SELGPYMKDL | GAQLDRLVVD | AAKEKREMEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KHSTIQQKDF | SSDDSKLEYN | VDAANGIVME | GYLFKRASNA | FKTWNRRWFS | IQNNQLVYQK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFKDNPTVVV | EDLRLCTVKH | CEDIERRFCF | EVVSPTKSCM | LQADSEKLRQ | AWIKAVQTSI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ATAYREKGDE | SEKLDKKSSP | STGSLDSGNE | SKEKLLKGES | ALQRVQCIPG | NASCCDCGLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DPRWASINLG | ITLCIECSGI | HRSLGVHFSK | VRSLTLDTWE | PELLKLMCEL | GNDVINRVYE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ANVEKMGIKK | PQPGQRQEKE | AYIRAKYVER | KFVDKYSISL | SPPEQQKKFV | SKSSEEKRLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ISKFGPGDQV | RASAQSSVRS | NDSGIQQSSD | DGRESLPSTV | SANSLYEPEG | ERQDSSMFLD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SKHLNPGLQL | YRASYEKNLP | KMAEALAHGA | DVNWANSEEN | KATPLIQAVL | GGSLVTCEFL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LQNGANVNQR | DVQGRGPLHH | ATVLGHTGQV | CLFLKRGANQ | HATDEEGKDP | LSIAVEAANA |
| 730 | 740 | 750 | 760 | 770 | |
| DIVTLLRLAR | MNEEMRESEG | LYGQPGDETY | QDIFRDFSQM | ASNNPEKLNR | FQQDSQKF |