Q5ZMN0
Gene name |
ANP32B (RCJMB04_1j7) |
Protein name |
Acidic leucine-rich nuclear phosphoprotein 32 family member B |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
gga:420087 |
EC number |
|
Protein Class |
|
Descriptions
(Annotation from UniProt)
The DAD domain may regulate activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition may be released upon competitive binding of an activated GTPase. The release of DAD may allow the FH2 domain to nucleate and elongate nonbranched actin filaments.
Autoinhibitory domains (AIDs)
Target domain |
1-163 (Leucine-rich region) |
Relief mechanism |
PTM, Others |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZMN0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZMN0-F1 | Predicted | AlphaFoldDB |
6 variants for Q5ZMN0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs731506341 | 20 | K>E | No | EVA | |
| rs739581884 | 60 | L>H | No | EVA | |
| rs315749135 | 72 | S>R | No | EVA | |
| rs1059954313 | 89 | N>K | No | EVA | |
| rs317780148 | 183 | D>Y | No | EVA | |
| rs1058424421 | 199 | E>D | No | EVA |
No associated diseases with Q5ZMN0
9 regional properties for Q5ZMN0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 630 - 853 | IPR003439-1 |
| domain | ABC transporter-like, ATP-binding domain | 1257 - 1489 | IPR003439-2 |
| domain | AAA+ ATPase domain | 657 - 830 | IPR003593-1 |
| domain | AAA+ ATPase domain | 1281 - 1466 | IPR003593-2 |
| domain | ABC transporter type 1, transmembrane domain | 315 - 596 | IPR011527-1 |
| domain | ABC transporter type 1, transmembrane domain | 938 - 1202 | IPR011527-2 |
| conserved_site | ABC transporter-like, conserved site | 755 - 769 | IPR017871 |
| domain | ABC transporter C family, six-transmembrane helical domain 2 | 936 - 1230 | IPR044726 |
| domain | ABC transporter C family, six-transmembrane helical domain 1 | 316 - 604 | IPR044746 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| protein-containing complex binding | Binding to a macromolecular complex. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P51122 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Bos taurus (Bovine) | SS |
| Q3SZC6 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Bos taurus (Bovine) | SS |
| Q5F4A3 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Gallus gallus (Chicken) | SS |
| Q9V895 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Drosophila melanogaster (Fruit fly) | SS |
| P39687 | ANP32A | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Homo sapiens (Human) | EV |
| Q9BTT0 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Homo sapiens (Human) | SS |
| Q92688 | ANP32B | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Homo sapiens (Human) | SS |
| O35381 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Mus musculus (Mouse) | SS |
| P97822 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Mus musculus (Mouse) | SS |
| Q9EST5 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Mus musculus (Mouse) | SS |
| Q5XIE0 | Anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Rattus norvegicus (Rat) | SS |
| P49911 | Anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Rattus norvegicus (Rat) | SS |
| Q9EST6 | Anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Rattus norvegicus (Rat) | SS |
| Q7Y180 | Os03g0668900 | Acidic leucine-rich nuclear phosphoprotein 32-related protein 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q9SCQ7 | At3g50690 | Acidic leucine-rich nuclear phosphoprotein 32-related protein | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q6P1U7 | anp32b | Acidic leucine-rich nuclear phosphoprotein 32 family member B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6NUW5 | anp32e | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7ZUP0 | anp32a | Acidic leucine-rich nuclear phosphoprotein 32 family member A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNAGSMDSQ | QTDFRAHNVP | LKLPMPEPGE | LEERFAIVLN | AMNLPPDKAR | LLRQYDNEKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WELICDQERF | QVKNPPHTYI | QKLKGYLDPA | VTRKKFRRRV | QESTQVLREL | EISLRTNHIG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WVREFLNEEN | KGLDVLVEYL | SFAQYAVTFD | FESVESTVES | SVDKSKPWSR | SIEDLHRGSN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPSPVGNSVS | RSGRHSALRY | NTLPSRRTLK | NSRLVSKKDD | VHVCIMCLRA | IMNYQYGFNM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VMSHPHAVNE | IALSLNNKNP | RTKALVLELL | AAVCLVRGGH | EIILSAFDNF | KEVCGEKQRF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKLMEHFRNE | DNNIDFMVAS | MQFINIVVHS | VEDMNFRVHL | QYEFTKLGLD | EYLDKLKHTE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SDKLQVQIQA | YLDNVFDVGA | LLEDAETKNA | ALERVEELEE | NISHLSEKLQ | DTENEAMSKI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VELEKQLMQR | NKELDVVREI | YKDANTQVHT | LRKMVKEKEE | AIQRQSTLEK | KIHELEKQGT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IKIQKKGDGD | IAILPVVASG | TLSMGSEVVA | GNSVGPTMGA | ASSGPLPPPP | PPLPPSSDTP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ETVQNGPVTP | PMPPPPPPPP | PPPPPPPPPP | PPPLPGPAAE | TVPAPPLAPP | LPSAPPLPGT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSPTVVFNSG | LAAVKIKKPI | KTKFRMPVFN | WVALKPNQIN | GTVFNEIDDE | RILEDLNVDE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FEEIFKTKAQ | GPAIDLSSSK | QKIPQKGSNK | VTLLEANRAK | NLAITLRKAG | KTADEICKAI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HVFDLKTLPV | DFVECLMRFL | PTENEVKVLR | LYERERKPLE | NLSDEDRFMM | QFSKIERLMQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KMTIMAFIGN | FAESIQMLTP | QLHAIIAASV | SIKSSQKLKK | ILEIILALGN | YMNSSKRGAV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YGFKLQSLDL | LLDTKSTDRK | QTLLHYISNV | VKEKYHQVSL | FYNELHYVEK | AAAVSLENVL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LDVKELQRGM | DLTKREYTMH | DHNTLLKEFI | LNNEGKLKKL | QDDAKIAQDA | FDDVVKYFGE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NPKTTPPSVF | FPVFVRFVKA | YKQAEEENEL | RKKQEQALME | KLLEQEALME | QQDPKSPSHK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SKRQQQELIA | ELRRRQVKDN | RHVYEGKDGA | IEDIITVLKT | VPFTARTAKR | GSRFFCEPVL |
| TEEYHY |