P43545

PR
Gene name
SNZ3 (YFL059W)
Protein name
Probable pyridoxal 5'-phosphate synthase subunit SNZ3
Names
PLP synthase subunit SNZ3, PDX1 homolog 3, Pdx1.3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YFL059W
EC number
4.3.3.6: Amine-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

138-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P43545

Entry ID Method Resolution Chain Position Source
AF-P43545-F1 Predicted AlphaFoldDB

6 variants for P43545

Variant ID(s) Position Change Description Diseaes Association Provenance
s06-11547 62 R>H No SGRP
s06-11844 161 I>N No SGRP
s06-11858 166 A>T No SGRP
s06-11896 178 E>D No SGRP
s06-11941 193 D>E No SGRP
s06-11955 198 T>I No SGRP

No associated diseases with P43545

1 regional properties for P43545

Type Name Position InterPro Accession
domain PdxS/SNZ N-terminal domain 4 - 211 IPR033755

Functions

Description
EC Number 4.3.3.6 Amine-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
amine-lyase activity Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate.
pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate.

4 GO annotations of biological process

Name Definition
cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
pyridoxal phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.
pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53824 SNZ2 Probable pyridoxal 5'-phosphate synthase subunit SNZ2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8W3D0 PDX12 Probable pyridoxal 5'-phosphate synthase subunit PDX1.2 Oryza sativa subsp japonica (Rice) PR
Q69LA6 PDX11 Probable pyridoxal 5'-phosphate synthase subunit PDX1.1 Oryza sativa subsp japonica (Rice) PR
O80448 PDX11 Pyridoxal 5'-phosphate synthase subunit PDX1.1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSEFKVKTGL AQMLKGGVIM DVVTPEQAII AERAGACAVM ALERIPADMR KSGQVCRMSD
70 80 90 100 110 120
PRMIKEIMEA VSIPVMAKVR IGHFVEAQIL EELQVDYIDE SEVLTPADWT HHIEKHNFKV
130 140 150 160 170 180
PFVCGAKDLG EALRRINEGA AMIRTKGEAG TGDVSEAVKH ITKIKAEIQQ YKENLKTESD
190 200 210 220 230 240
FAAKATELRV PVDLLKTTLS EGKLPVVNFA AGGVATPADA ALLMQLGCEG VFVGSGIFKS
250 260 270 280 290
SDPEKLACAI VEATTHYDNP AKLLQVSSDL GDLMGGISIQ SINEAGGKNG ARLSEIGW