O80448
Gene name |
PDX11 (PDX1L1, At2g38230, F16M14.16) |
Protein name |
Pyridoxal 5'-phosphate synthase subunit PDX1.1 |
Names |
AtPDX1.1, AtPDX12, PLP synthase subunit PDX1.1, HEVER-like protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G38230 |
EC number |
4.3.3.6: Amine-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O80448
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5LNT | X-ray | 232 A | A/B/C/D | 1-309 | PDB |
| AF-O80448-F1 | Predicted | AlphaFoldDB |
21 variants for O80448
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05676578 | 72 | Q>L | No | 1000Genomes | |
| ENSVATH05676579 | 76 | A>S | No | 1000Genomes | |
| ENSVATH05676580 | 90 | A>V | No | 1000Genomes | |
| ENSVATH01964182 | 118 | V>I | No | 1000Genomes | |
| ENSVATH14595404 | 146 | C>G | No | 1000Genomes | |
| ENSVATH05676582 | 148 | N>D | No | 1000Genomes | |
| ENSVATH00264397 | 152 | A>G | No | 1000Genomes | |
| tmp_2_16011944_G_A | 157 | R>H | No | 1000Genomes | |
| ENSVATH00264399 | 184 | V>L | No | 1000Genomes | |
| tmp_2_16012090_A_G | 206 | I>V | No | 1000Genomes | |
| tmp_2_16012094_C_T | 207 | A>V | No | 1000Genomes | |
| tmp_2_16012186_G_T | 238 | A>S | No | 1000Genomes | |
| ENSVATH05676590 | 242 | M>L | No | 1000Genomes | |
| ENSVATH14595405 | 244 | L>F | No | 1000Genomes | |
| ENSVATH05676591 | 260 | D>N | No | 1000Genomes | |
| tmp_2_16012310_C_A | 279 | A>E | No | 1000Genomes | |
| ENSVATH14595406 | 279 | A>T | No | 1000Genomes | |
| ENSVATH05676592 | 288 | L>V | No | 1000Genomes | |
| tmp_2_16012361_A_G | 296 | N>S | No | 1000Genomes | |
| tmp_2_16012374_G_C | 300 | K>N | No | 1000Genomes | |
| tmp_2_16012373_A_C | 300 | K>T | No | 1000Genomes |
No associated diseases with O80448
1 regional properties for O80448
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PdxS/SNZ N-terminal domain | 24 - 229 | IPR033755 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.3.3.6 | Amine-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| amine-lyase activity | Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity | Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
| pyridoxal phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. |
| pyridoxine biosynthetic process | The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53824 | SNZ2 | Probable pyridoxal 5'-phosphate synthase subunit SNZ2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P43545 | SNZ3 | Probable pyridoxal 5'-phosphate synthase subunit SNZ3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q69LA6 | PDX11 | Probable pyridoxal 5'-phosphate synthase subunit PDX1.1 | Oryza sativa subsp japonica (Rice) | PR |
| Q8W3D0 | PDX12 | Probable pyridoxal 5'-phosphate synthase subunit PDX1.2 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGTGVVAVY | GEGAMTETKQ | KSPFSVKVGL | AQMLRGGVIM | DVVNAEQARI | AEEAGACAVM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALERVPADIR | AQGGVARMSD | PEMIKEIKNA | VTIPVMAKAR | IGHFVEAQIL | EAIGVDYVDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEVLTLADED | NHINKHNFKI | PFVCGCRNLG | EALRRIREGA | AMIRTKGEAG | TGNVVEAVRH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VRSVNGAIRL | LRSMDDDEVF | TYAKKIAAPY | DLVVQTKELG | RLPVVQFAAG | GVATPADAAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MMQLGCDGVF | VGSGVFKSGD | PVKRAKAIVQ | AVTNYRDAAV | LAEVSCGLGE | AMVGLNLDDK |
| VERFASRSE |