P35980

PR
Gene name
Rpl18
Protein name
60S ribosomal protein L18
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:19899
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

121-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P35980

Entry ID Method Resolution Chain Position Source
6SWA EM 310 A P 1-188 PDB
7CPU EM 282 A LQ 1-188 PDB
7CPV EM 303 A LQ 1-188 PDB
7LS1 EM 330 A K2 1-188 PDB
7LS2 EM 310 A K2 1-188 PDB
AF-P35980-F1 Predicted AlphaFoldDB

6 variants for P35980

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388914529 4 D>N No EVA
rs3388903545 46 V>A No EVA
rs3388900518 46 V>I No EVA
rs3398018635 67 I>V No EVA
rs3388907886 68 R>L No EVA
rs3388911356 113 I>V No EVA

No associated diseases with P35980

2 regional properties for P35980

Type Name Position InterPro Accession
domain Ribosomal protein L18e/L15P 2 - 188 IPR021131
conserved_site Ribosomal protein L18/L18-A/B/e, conserved site 49 - 66 IPR021132

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasm
  • Rough endoplasmic reticulum
  • Detected on cytosolic polysomes (By similarity)
  • Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic large ribosomal subunit The large subunit of a ribosome located in the cytosol.
cytosolic ribosome A ribosome located in the cytosol.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
polysomal ribosome A ribosome bound to mRNA that forms part of a polysome.
rough endoplasmic reticulum The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

2 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q07020 RPL18 60S ribosomal protein L18 Homo sapiens (Human) PR
O22254 RPL18A Putative 60S ribosomal protein L18-1 Arabidopsis thaliana (Mouse-ear cress) PR
P42791 RPL18B 60S ribosomal protein L18-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q940B0 RPL18C 60S ribosomal protein L18-3 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP
70 80 90 100 110 120
LSLSRMIRKM KLPGRENKTA VVVGTVTDDV RILEVPKLKV CALRVSSRAR SRILKAGGKI
130 140 150 160 170 180
LTFDQLALES PKGRGTVLLS GPRKGREVYR HFGKAPGTPH SHTKPYVRSK GRKFERARGR
RASRGYKN