P34319
Gene name |
best-5 (C07A9.8) |
Protein name |
Bestrophin homolog 5 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C07A9.8 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P34319
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P34319-F1 | Predicted | AlphaFoldDB |
No variants for P34319
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P34319 | |||||
No associated diseases with P34319
5 regional properties for P34319
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 34 - 285 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 152 - 164 | IPR008271 |
| domain | Ubiquitin-associated domain | 314 - 356 | IPR015940 |
| binding_site | Protein kinase, ATP binding site | 40 - 63 | IPR017441 |
| domain | BRSK1/2-like, UBA domain | 314 - 367 | IPR048622 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NFU0 | BEST4 | Bestrophin-4 | Homo sapiens (Human) | SS |
| Q8NFU1 | BEST2 | Bestrophin-2a | Homo sapiens (Human) | SS |
| Q8N1M1 | BEST3 | Bestrophin-3 | Homo sapiens (Human) | SS |
| O76090 | BEST1 | Bestrophin-1 | Homo sapiens (Human) | SS |
| O88870 | Best1 | Bestrophin-1 | Mus musculus (Mouse) | SS |
| Q6H1V1 | Best3 | Bestrophin-3 | Mus musculus (Mouse) | EV |
| Q8BGM5 | Best2 | Bestrophin-2 | Mus musculus (Mouse) | SS |
| O18303 | best-25 | Bestrophin homolog 25 | Caenorhabditis elegans | PR |
| O45435 | best-13 | Bestrophin homolog 13 | Caenorhabditis elegans | PR |
| P34672 | best-24 | Bestrophin homolog 24 | Caenorhabditis elegans | PR |
| Q19978 | best-14 | Bestrophin homolog 14 | Caenorhabditis elegans | PR |
| Q23369 | best-22 | Bestrophin homolog 22 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTNNNDPKCV | VIEEPDDVPV | KPPKIFDFTD | WPFEIPDIFK | RKELSYNYNY | DLATSKSLMI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VRMIFKWRGS | LWQAVYKELI | VWICAYSLVS | VIYRFALTRS | QKDIFERFGE | YCDARMGYLP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNFVLGFFCN | IIIRRWLKLY | TSLGNIDNIA | LFVSAYVRGT | DDRARQIRRN | IIRYCVISQC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVFRDIHVGV | RRRFPTLEAV | AQAGIMLPHE | LEKFNSIKSR | YQKYWVSFNW | ALELLNVAKT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EKSIDGDNAR | NAIAQEISKF | RSALTTVSMY | DWVPIPLMYP | QLVNMAVHTY | FFLCIFTRQF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FISADAHNKT | EVDLYIPFMT | IIEFIFYMGW | LKVAMELLNP | FGEDADDFDC | NLLIDRNLAI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLTSVDDAYD | QLPEVKPDVF | TGGSVKPLDS | DDTRSLKYHF | GSAAQMEEIS | YLKKEENKMI |
| 430 | 440 | 450 | |||
| AAGKKPNKLK | LWVKSVRRKR | FETSATQPSF | PIP |