O18303

PR
Gene name
best-25 (ZK849.4)
Protein name
Bestrophin homolog 25
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_ZK849.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

410-602 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O18303

Entry ID Method Resolution Chain Position Source
AF-O18303-F1 Predicted AlphaFoldDB

No variants for O18303

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O18303

No associated diseases with O18303

9 regional properties for O18303

Type Name Position InterPro Accession
domain SANT/Myb domain 135 - 263 IPR001005-1
domain SANT/Myb domain 430 - 478 IPR001005-2
domain SET domain 613 - 734 IPR001214
domain CXC domain 504 - 606 IPR026489
domain Tesmin/TSO1-like CXC domain 556 - 593 IPR033467
domain Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain 159 - 262 IPR041343
domain Pre-SET CXC domain 560 - 591 IPR041355
domain EZH1, SET domain 608 - 743 IPR044438
domain EZH1/2, MCSS domain 270 - 322 IPR048358

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloride channel complex An ion channel complex through which chloride ions pass.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NFU0 BEST4 Bestrophin-4 Homo sapiens (Human) SS
Q8NFU1 BEST2 Bestrophin-2a Homo sapiens (Human) SS
Q8N1M1 BEST3 Bestrophin-3 Homo sapiens (Human) SS
O76090 BEST1 Bestrophin-1 Homo sapiens (Human) SS
O88870 Best1 Bestrophin-1 Mus musculus (Mouse) SS
Q6H1V1 Best3 Bestrophin-3 Mus musculus (Mouse) EV
Q8BGM5 Best2 Bestrophin-2 Mus musculus (Mouse) SS
O45435 best-13 Bestrophin homolog 13 Caenorhabditis elegans PR
P34319 best-5 Bestrophin homolog 5 Caenorhabditis elegans PR
P34672 best-24 Bestrophin homolog 24 Caenorhabditis elegans PR
Q19978 best-14 Bestrophin homolog 14 Caenorhabditis elegans PR
Q23369 best-22 Bestrophin homolog 22 Caenorhabditis elegans PR
10 20 30 40 50 60
MHKVHIIYSR IFQMTVTYNR AVSTESIHNF VSIMSYWHGS LVKSIWKEYA IWIVLYHLIL
70 80 90 100 110 120
FIYRVVMPIF GWADYCKKVI ENWTPHQDMT IPLEFLLGFF VTTVIDRWRK AFQNIPYIEI
130 140 150 160 170 180
CAFAVAAAIP GRIRIINKKQ NEVRAPGGQD LRDVPAVEVN HPVQRGPEAP AAALPMPGAP
190 200 210 220 230 240
ERPAVALPMP GAPEGPAAIQ QPSVDVKLTA RRTIIRYLVL SQILLFREIS TKVKKRFVDL
250 260 270 280 290 300
KCLVDSKFLT DEELKILSKE VKCDHYDSYF LPINWAFSIL QEHKVKSNPE FINAWNVIRD
310 320 330 340 350 360
WQVKLSLLRN GDFIPIPLAY PQAVFLAIRF YFLVCLFTRQ HLDMDDKKSI DYYFPLMTSL
370 380 390 400 410 420
QFIFIVGWMK VAEILLNPMG EDDDDFELNN IIDKNLYIGL AIVDTECGKH PEIVKDTIGK
430 440 450 460 470 480
DCLPFYPQND DDNERNRALV GSTKNINLSG RSDTPAASPS VFYVNINVKV ENPTPVIVDG
490 500 510 520 530 540
ARPPPSPPAL PPALPNPNEP PPPPPPAEAL RADQPRHSLI HEVGAQADPA EANGAQALSP
550 560 570 580 590 600
VLPNPNERAD EHGHSPVIDN EAQPSPPPAE ANRAPIPNQQ PQVNGNAAPA SPRQAKVPDD
PH