O45435
Gene name |
best-13 (F32B6.9) |
Protein name |
Bestrophin homolog 13 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F32B6.9 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O45435
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O45435-F1 | Predicted | AlphaFoldDB |
No variants for O45435
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O45435 | |||||
No associated diseases with O45435
6 regional properties for O45435
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 191 - 453 | IPR000719 |
| domain | AGC-kinase, C-terminal | 454 - 533 | IPR000961 |
| domain | Pleckstrin homology domain | 558 - 654 | IPR001849 |
| active_site | Serine/threonine-protein kinase, active site | 313 - 325 | IPR008271 |
| domain | RGS domain | 54 - 175 | IPR016137 |
| binding_site | Protein kinase, ATP binding site | 197 - 220 | IPR017441 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NFU0 | BEST4 | Bestrophin-4 | Homo sapiens (Human) | SS |
| Q8NFU1 | BEST2 | Bestrophin-2a | Homo sapiens (Human) | SS |
| Q8N1M1 | BEST3 | Bestrophin-3 | Homo sapiens (Human) | SS |
| O76090 | BEST1 | Bestrophin-1 | Homo sapiens (Human) | SS |
| O88870 | Best1 | Bestrophin-1 | Mus musculus (Mouse) | SS |
| Q6H1V1 | Best3 | Bestrophin-3 | Mus musculus (Mouse) | EV |
| Q8BGM5 | Best2 | Bestrophin-2 | Mus musculus (Mouse) | SS |
| O18303 | best-25 | Bestrophin homolog 25 | Caenorhabditis elegans | PR |
| P34319 | best-5 | Bestrophin homolog 5 | Caenorhabditis elegans | PR |
| P34672 | best-24 | Bestrophin homolog 24 | Caenorhabditis elegans | PR |
| Q19978 | best-14 | Bestrophin homolog 14 | Caenorhabditis elegans | PR |
| Q23369 | best-22 | Bestrophin homolog 22 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTISYSGNVI | RILLRWKGSI | WRTAWKELLI | YLILYYSVRV | FYLKGIDLID | DDEDDRLKMR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RMFETFCRQC | DSYTRLIPLT | FLLGFYVSNV | VARWWRQFET | LYWPEDILSV | LCTVLHQHDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSKRRRHTIA | RYLNLANALA | WRDISSKIRL | RFPSVHSLIE | SGLLTEKEYQ | ILEAMHAENE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSRWITPLHW | IQLIMRQVEE | EHKPTASLFN | QFVGELRIFR | QSLRKLYSYD | WVCVPLVYTQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAALATYSFF | FFTLFGRQPL | FPDIETGKEL | DLVVPVFTIV | QFLFFVGWFK | VGQDLMRPFG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDDDDIELNY | ILDRNVRISF | AIVNQLQESP | IPDFESNDDK | LWHEMHPPTK | DGETSPIPRI |
| 370 | 380 | 390 | 400 | 410 | |
| PQLPHSKYSK | QLSEHPPRLH | AYVPIDDGKG | SIKDLESHHG | CVSLKKDKKH | ISW |