P23249
PR
Gene name |
Mov10 (Gb110) |
Protein name |
Putative helicase MOV-10 |
Names |
Moloney leukemia virus 10 protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17454 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P23249
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P23249-F1 | Predicted | AlphaFoldDB |
47 variants for P23249
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs227532316 | 41 | H>Q | No | EVA | |
| rs3388651517 | 48 | G>R | No | EVA | |
| rs3388658695 | 50 | P>S | No | EVA | |
| rs3388636099 | 105 | S>P | No | EVA | |
| rs3388643692 | 108 | A>V | No | EVA | |
| rs13459070 | 142 | H>R | No | EVA | |
| rs864278832 | 159 | G>R | No | EVA | |
| rs3393494849 | 174 | T>K | No | EVA | |
| rs3393024325 | 175 | P>T | No | EVA | |
| rs3388652905 | 244 | S>R | No | EVA | |
| rs3388651532 | 259 | P>T | No | EVA | |
| rs3388659197 | 271 | R>Q | No | EVA | |
| rs3412942314 | 287 | E>D | No | EVA | |
| rs3388651527 | 299 | I>T | No | EVA | |
| rs3388656480 | 394 | R>* | No | EVA | |
| rs3388651490 | 402 | L>F | No | EVA | |
| rs3388643671 | 414 | Y>C | No | EVA | |
| rs3388655893 | 422 | E>* | No | EVA | |
| rs3388651524 | 423 | L>M | No | EVA | |
| rs864290441 | 442 | L>R | No | EVA | |
| rs3388652843 | 454 | P>T | No | EVA | |
| rs246717088 | 478 | A>S | No | EVA | |
| rs3388656453 | 527 | P>S | No | EVA | |
| rs3388644290 | 529 | T>I | No | EVA | |
| rs3388658653 | 533 | V>D | No | EVA | |
| rs3393484133 | 583 | S>R | No | EVA | |
| rs3388658661 | 611 | K>N | No | EVA | |
| rs3393403540 | 623 | T>S | No | EVA | |
| rs3393494904 | 624 | L>P | No | EVA | |
| rs3388652501 | 686 | G>E | No | EVA | |
| rs3388656455 | 696 | K>T | No | EVA | |
| rs3388643663 | 714 | Y>F | No | EVA | |
| rs3388656481 | 719 | N>I | No | EVA | |
| rs3388652478 | 726 | I>T | No | EVA | |
| rs3388652816 | 739 | I>L | No | EVA | |
| rs3388657604 | 758 | V>M | No | EVA | |
| rs3388656462 | 772 | Q>* | No | EVA | |
| rs3388644249 | 774 | G>D | No | EVA | |
| rs30355675 | 835 | R>Q | No | EVA | |
| rs3388654648 | 886 | Q>R | No | EVA | |
| rs3388643715 | 895 | F>L | No | EVA | |
| rs3388644260 | 940 | K>* | No | EVA | |
| rs3388656454 | 940 | K>E | No | EVA | |
| rs3388658627 | 944 | G>E | No | EVA | |
| rs586994849 | 978 | R>C | No | EVA | |
| rs3388650472 | 984 | Q>H | No | EVA | |
| rs3388650467 | 1003 | E>G | No | EVA |
No associated diseases with P23249
5 regional properties for P23249
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase MOV-10/SDE3, DEXXQ/H-box helicase domain | 499 - 734 | IPR026122 |
| domain | DNA2/NAM7 helicase, helicase domain | 500 - 569 | IPR041677-1 |
| domain | DNA2/NAM7 helicase, helicase domain | 611 - 691 | IPR041677-2 |
| domain | DNA2/NAM7 helicase-like, C-terminal | 700 - 923 | IPR041679 |
| domain | Upf1-like, C-terminal helicase domain | 735 - 940 | IPR047187 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic ribonucleoprotein granule | A ribonucleoprotein granule located in the cytoplasm. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P granule | A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-3' RNA helicase activity | Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| 3'-UTR-mediated mRNA destabilization | An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. |
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| miRNA-mediated gene silencing | A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. |
| miRNA-mediated gene silencing by mRNA destabilization | An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. |
| negative regulation of transposition, RNA-mediated | Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate. |
| positive regulation of mRNA catabolic process | Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| regulation of neuron projection arborization | Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZKD7 | MOV10 | Putative helicase MOV-10 | Gallus gallus (Chicken) | PR |
| Q9HCE1 | MOV10 | Helicase MOV-10 | Homo sapiens (Human) | PR |
| Q8CFQ3 | Aqr | RNA helicase aquarius | Mus musculus (Mouse) | PR |
| Q8GYD9 | SDE3 | Probable RNA helicase SDE3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSKFSCRKL | RETGQRFESF | LAERGLDLET | DRERLRTIYN | HDFKPSYGTP | APGFSSMLYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MKIANLAFVT | KTRVRFFKLD | RWADVQLPEK | RRIKPGSNIS | KQHRSLLARI | FHDRAEYLHG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KHGVDVEVQG | PHEARDGQLL | IHLDLNRKEV | LTLRLRNGGS | KPVTLTHLFP | LCWTPQFVFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HGEQDLPCPL | GPGESYELHI | YCKTSIVGYF | PATVLWELLG | PGESGAEGAE | TFYIARFLAA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAHSPLAAQL | KPTTPFKRPP | RLTRNSVLTN | RIEEGERPDR | AKGYELELSL | ALGTYYPPIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRQLLPTLLQ | GPSIFTAPKE | VAEIKAQLET | TLKSRNYEVK | LRLLLHLEEL | QMEHDIRHYD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LDSVPMTWDP | VDQNPRLLTL | EVPGVAESRP | SVLRGDHLFA | LLSSETQQDD | PVTYKGFVHK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VELDRVKLSF | STSLLSRFVD | GLTFKVNFTF | NRQPLRVQHR | ALELTGRWVL | WPMLFPVASR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GVSLLPSDVK | FKLYDRSLES | NPEQLQAMKH | IVRGTTRPAP | YIIFGPPGTG | KTVTLVEAIK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QVVKHLPKAH | ILACAPSNSG | ADLLCQRLRV | HLPSSIYRLL | APSRDIRMVP | EDIKTCCNWD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AKKGEYVYPA | KKHLQQYRVL | ITTLITASRL | VSAQFPIDHF | THIFIDEAGH | CMEPESLVAI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AGLMDVKETG | NPGGQLVLAG | DPRQLGPVLR | SPLALKHGLG | YSLLERLLAY | NSLYKKGPNG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YDPQFITKLL | RNYRSHPTIL | DIPNQLYYDG | ELQACADVVD | RERFCRWEGL | PQQGFPIIFH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GVMGKDEREG | NSPSFFNPEE | AATVTSYLKQ | LLAPSSKKGK | ARLSPRNVGV | ISPYRKQVEK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IRYCITKLDR | ELRGLDDIKD | LKVGSVEEFQ | GQERSVILIS | TVRSSQSFVQ | LDLDFNLGFL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KNPKRFNVAV | TRAKALLIVV | GNPLLLGHDP | DWKTFLEFCK | ENGGYTGCPF | PAKLDLQQGQ |
| 970 | 980 | 990 | 1000 | ||
| DLLQGLSKLS | PSTSGPRRHQ | NLPQEREGEG | GLPLQVEPEW | RNEL |