AiPD: Autoinhibited Protein Database

Q9HCE1

Gene name	MOV10
Protein name	Helicase MOV-10
Names	Armitage homolog, Moloney leukemia virus 10 protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4343
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

933-1003 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

933-1003 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9HCE1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9HCE1-F1	Predicted				AlphaFoldDB

671 variants for Q9HCE1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1674524213 RCV001270187	944	Y>C	Premature ovarian failure [ClinVar]	Yes	ClinVar dbSNP
TCGA novel	3	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1009403 rs201021656	8	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1009404 rs201021656	8	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1261144526 CA341657925	8	R>W		No	ClinGen gnomAD
CA1009405 COSM527358 rs757439589	11	R>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA28932175 rs921435174	11	R>W		No	ClinGen Ensembl
CA1009407 rs750261841	12	E>A		No	ClinGen ExAC TOPMed gnomAD
CA341657962 rs1399003142	12	E>K		No	ClinGen TOPMed
CA341658011 rs1430194817	16	C>Y		No	ClinGen gnomAD
CA341658037 rs1476462227	18	E>G		No	ClinGen TOPMed
CA1009409 rs4436392	18	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA341658063 rs1402382909	20	F>L		No	ClinGen gnomAD
rs749178705 CA1009410	24	R>Q		No	ClinGen ExAC gnomAD
CA341658139 rs1339040561	25	G>E		No	ClinGen gnomAD
rs1356051346 CA341658172	27	D>G		No	ClinGen gnomAD
CA1009412 rs778301654	28	M>V		No	ClinGen ExAC
rs747646761 CA1009413	32	R>S		No	ClinGen ExAC TOPMed gnomAD
CA341658250 rs1487424564	33	E>K		No	ClinGen TOPMed
CA341658269 rs1348865725	34	R>W		No	ClinGen TOPMed gnomAD
rs771890048 CA1009414	36	R>W		No	ClinGen ExAC gnomAD
rs1253949409 CA341658303	37	T>I		No	ClinGen gnomAD
CA341658335 rs1570738607	40	N>T		No	ClinGen Ensembl
CA1009415 rs772974608	41	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1178960804 CA341658360	42	D>N		No	ClinGen gnomAD
TCGA novel	44	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1381949786 CA341658405	44	K>R		No	ClinGen gnomAD
TCGA novel	46	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1432145788 CA341659922	48	G>E		No	ClinGen gnomAD
CA1009434 rs535795554	49	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1570777436 CA341659925	49	T>P		No	ClinGen Ensembl
CA1009436 rs561408204	51	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1323344238 CA341659943	52	P>S		No	ClinGen gnomAD
CA341659976 rs1391988109	57	M>K		No	ClinGen gnomAD
rs749621392 CA1009437	57	M>L		No	ClinGen ExAC gnomAD
CA1009438 rs769086801	59	Y>C		No	ClinGen ExAC
CA1009440 rs761943431	63	I>M		No	ClinGen ExAC gnomAD
rs774901640 CA1009439	63	I>T		No	ClinGen ExAC gnomAD
CA341660017 rs1449778327	63	I>V		No	ClinGen gnomAD
CA341660028 rs1218095632	65	N>D		No	ClinGen gnomAD
CA341660031 rs1260418243	65	N>S		No	ClinGen TOPMed gnomAD
rs1557758951 CA341660044	67	A>G		No	ClinGen Ensembl
CA1009441 rs142716470	68	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs760900913 CA1009444	69	V>F		No	ClinGen ExAC TOPMed gnomAD
rs760900913 CA1009443	69	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1425963286 CA341660087	71	K>R		No	ClinGen gnomAD
rs530067492 CA1009446	73	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1009445 rs753608129	73	R>W		No	ClinGen ExAC gnomAD
rs898051637 CA28940601	74	V>F		No	ClinGen gnomAD
rs898051637 CA341660110	74	V>I		No	ClinGen gnomAD
rs1249458430 CA341660122	75	R>K		No	ClinGen TOPMed
CA341660128 rs1300039529	75	R>S		No	ClinGen gnomAD
rs1343577793 CA341660138	76	F>Y		No	ClinGen gnomAD
rs765144227 CA341660173	79	L>F		No	ClinGen ExAC TOPMed gnomAD
rs752675873 CA1009448	79	L>P		No	ClinGen ExAC TOPMed gnomAD
CA1009447 rs765144227	79	L>V		No	ClinGen ExAC TOPMed gnomAD
CA1009450 rs777431510	80	D>N		No	ClinGen ExAC TOPMed gnomAD
rs142209700 CA1009451	81	R>C		No	ClinGen ESP ExAC gnomAD
CA341660202 rs1353895265	81	R>H		No	ClinGen TOPMed gnomAD
rs756998623 CA1009452	83	A>V		No	ClinGen ExAC gnomAD
CA1009456 COSM674304 rs769053734	84	D>E	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs370478051 CA1009454	84	D>N		No	ClinGen ExAC TOPMed gnomAD
CA341660235 rs1215671055	84	D>V		No	ClinGen gnomAD
CA1009457 rs748662950	85	V>M		No	ClinGen ExAC gnomAD
rs772510801 CA1009458	86	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1295849842 CA341660243	86	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA341660256 rs1223287112	88	P>S		No	ClinGen gnomAD
CA1009460 rs200320463	90	K>N		No	ClinGen ExAC TOPMed gnomAD
CA1009461 rs760706906	93	M>I		No	ClinGen ExAC gnomAD
CA1009462 rs771106179	95	L>P		No	ClinGen ExAC TOPMed gnomAD
CA341660308 rs771106179	95	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs965415458 CA341660312	96	G>E		No	ClinGen TOPMed gnomAD
rs965415458 CA28940719	96	G>V		No	ClinGen TOPMed gnomAD
CA1009463 rs370943143	99	I>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs759316287 CA1009464	100	S>G		No	ClinGen ExAC gnomAD
CA341660347 rs1437210400	101	K>N		No	ClinGen TOPMed
rs1377443369 CA341660359	103	H>Y		No	ClinGen gnomAD
CA1009468 rs763001472	108	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1277456835 CA341660394	108	A>V		No	ClinGen gnomAD
CA1009469 rs764080471	109	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1272791331 CA341660399	109	K>R		No	ClinGen TOPMed
CA341660402 rs1331310640	110	I>L		No	ClinGen TOPMed
rs112819798 CA28940767	112	Y>C		No	ClinGen Ensembl
CA341660431 rs1211287542	113	D>E		No	ClinGen gnomAD
CA341660432 rs1280139404	114	R>G		No	ClinGen gnomAD
TCGA novel	114	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1009491 rs762808148	119	H>R		No	ClinGen ExAC gnomAD
CA341661101 rs1485599954	120	G>A		No	ClinGen TOPMed
CA1009492 rs764172622	121	K>E		No	ClinGen ExAC gnomAD
CA341661128 rs1557759789	122	H>D		No	ClinGen Ensembl
CA341661140 rs1395587995	123	G>S		No	ClinGen gnomAD
rs1343304614 CA341661161	125	D>N		No	ClinGen TOPMed
rs576181686 CA1009494	126	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1213596168 CA341661211	129	Q>R		No	ClinGen TOPMed
CA341661275 rs1403751867	134	A>V		No	ClinGen gnomAD
rs147811471 CA1009496	135	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs755814593 CA1009497	136	D>G		No	ClinGen ExAC gnomAD
rs1341606707 CA341661288	136	D>N		No	ClinGen TOPMed gnomAD
CA1009499 rs376126674	140	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341661339 rs1381738704	140	L>R		No	ClinGen gnomAD
rs376126674 CA1009498	140	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150316337 CA28944065	141	I>T		No	ClinGen ESP TOPMed
rs758746811 CA1009500	142	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1009502 rs116655742	142	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1009501 rs116655742	142	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1489928734 CA341661374	144	D>G		No	ClinGen gnomAD
rs771284179 CA1009503	144	D>H		No	ClinGen ExAC gnomAD
CA1009504 rs781350691	145	L>V		No	ClinGen ExAC gnomAD
rs149029432 CA1009505	147	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs770092703 CA1009506	147	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA341661404 rs1191010617	149	E>K		No	ClinGen gnomAD
rs1229285420 CA341661413	150	V>L		No	ClinGen gnomAD
rs749155784 CA1009508	151	L>P		No	ClinGen ExAC gnomAD
CA1009510 rs768570170	152	T>A		No	ClinGen ExAC
rs984338977 CA28944116	152	T>N		No	ClinGen TOPMed
rs1557760037 CA341661433	154	R>K		No	ClinGen Ensembl
CA341661436 rs1255574071	154	R>S		No	ClinGen TOPMed
rs761827588 CA1009512	156	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	156	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341661459 rs1423610309	158	G>D		No	ClinGen TOPMed gnomAD
CA1009514 rs368056345	159	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA341661498 rs1202889083	164	T>I		No	ClinGen TOPMed
CA28944157 rs916698901	165	L>V		No	ClinGen TOPMed gnomAD
CA1009515 rs760074539	168	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1009518 rs754556608	169	F>L		No	ClinGen ExAC TOPMed gnomAD
CA1009517 rs753482453	169	F>L		No	ClinGen ExAC gnomAD
rs1290953232 CA341661530	170	P>A		No	ClinGen TOPMed
CA341661537 rs1357473822	171	L>F		No	ClinGen gnomAD
rs1286812272 CA341661546	172	C>F		No	ClinGen gnomAD
CA341661542 rs1245608525	172	C>R		No	ClinGen gnomAD
CA1009520 rs574586722	173	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1009519 rs764455810	173	R>W		No	ClinGen ExAC gnomAD
rs370341687 CA1009523	174	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1009522 rs370341687	174	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs146126921 CA1009524	175	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1326816490 CA341661563	176	Q>*		No	ClinGen TOPMed
CA1009527 rs768945998	177	F>L		No	ClinGen ExAC gnomAD
rs749529517 CA1009526	177	F>L		No	ClinGen ExAC gnomAD
CA1009529 rs373787928	179	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009531 rs773003438	180	Y>C		No	ClinGen ExAC gnomAD
CA1009533 rs765876798	181	N>K		No	ClinGen ExAC gnomAD
CA1009532 rs760298300	181	N>S		No	ClinGen ExAC TOPMed gnomAD
CA1009534 rs371779632	185	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341661632 rs1318988871	186	L>M		No	ClinGen gnomAD
TCGA novel	188	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1009535 rs759208673	191	G>A		No	ClinGen ExAC TOPMed gnomAD
CA341661671 rs1570780638	192	P>S		No	ClinGen Ensembl
CA341661675 rs757536290	193	G>R		No	ClinGen ExAC TOPMed gnomAD
CA1009538 rs757536290	193	G>S		No	ClinGen ExAC TOPMed gnomAD
rs199744267 CA1009559	196	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA28944535 rs768468337	199	H>L		No	ClinGen TOPMed gnomAD
rs768468337 CA341661734	199	H>R		No	ClinGen TOPMed gnomAD
CA341661737 rs1481156620	200	V>I		No	ClinGen gnomAD
rs766957320 CA1009560	201	H>N		No	ClinGen ExAC
CA1009561 rs376355139	204	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1486580181 CA341661798	208	G>V		No	ClinGen TOPMed
rs1480404698 CA341661802	209	Y>C		No	ClinGen gnomAD
CA341661804 rs1480404698	209	Y>S		No	ClinGen gnomAD
CA341661810 rs1570781420	210	F>S		No	ClinGen Ensembl
rs1258143023 CA341661817	211	P>S		No	ClinGen TOPMed
rs1171485346 CA341661832	213	T>I		No	ClinGen gnomAD
CA28944555 rs549838098	214	V>G		No	ClinGen 1000Genomes
rs1570781488 CA341661887	222	G>A		No	ClinGen Ensembl
rs369273991 CA28944570	224	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009562 rs369273991	224	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1297858657 CA341661913	227	E>K		No	ClinGen gnomAD
TCGA novel	229	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1009566 rs200470042	230	G>S		No	ClinGen ExAC TOPMed gnomAD
CA341661949 rs1281467008	232	F>C		No	ClinGen gnomAD
CA341661946 rs1356253726	232	F>V		No	ClinGen TOPMed
rs116379281 CA28944597	233	Y>H		No	ClinGen 1000Genomes
rs770891090 CA341661959	234	I>L		No	ClinGen ExAC TOPMed gnomAD
CA1009568 rs770891090	234	I>V		No	ClinGen ExAC TOPMed gnomAD
rs141479017 CA1009569	235	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009570 rs201458678	236	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009571 rs769180599	236	R>H		No	ClinGen ExAC gnomAD
rs775001346 CA1009572	240	A>G		No	ClinGen ExAC gnomAD
rs139270756 CA1009574	241	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341662007 rs1490325825	242	A>T		No	ClinGen TOPMed gnomAD
CA1009577 rs767043168	243	H>R		No	ClinGen ExAC TOPMed gnomAD
CA1009576 rs761090506	243	H>Y		No	ClinGen ExAC
rs867436323 CA341662026	245	P>H		No	ClinGen gnomAD
rs867436323 CA28944659	245	P>L		No	ClinGen gnomAD
CA28944658 rs369968810	245	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs369968810 CA1009579	245	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA341662028 rs1426788929	246	L>M		No	ClinGen gnomAD
CA1009580 rs765244376	248	A>S		No	ClinGen ExAC gnomAD
rs1365104438 CA341662044	249	Q>K		No	ClinGen gnomAD
CA341662069 rs1196182464	252	P>L		No	ClinGen TOPMed
CA1009583 rs764346509	253	M>K		No	ClinGen ExAC TOPMed gnomAD
rs752772081 CA1009582	253	M>L		No	ClinGen ExAC TOPMed gnomAD
CA341662072 rs764346509	253	M>T		No	ClinGen ExAC TOPMed gnomAD
rs752772081 CA1009581	253	M>V		No	ClinGen ExAC TOPMed gnomAD
CA28944678 rs1030672648	254	T>N		No	ClinGen TOPMed
rs751400244 CA1009584	255	P>H		No	ClinGen ExAC gnomAD
CA1009588 rs147230995	258	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147230995 CA341662104	258	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147230995 CA1009587	258	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1009586 rs571867196	258	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1009594 rs768238276	260	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1009593 rs748795486	260	R>W		No	ClinGen ExAC TOPMed
rs747439667 CA1009596 COSM3399540	263	G>R	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1009597 rs771420158	265	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1446661219 CA341662167	269	N>S		No	ClinGen TOPMed gnomAD
CA28944770 rs963236566	270	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1009599 rs759980674	270	R>W		No	ClinGen ExAC gnomAD
CA341662203 rs1343306092	275	E>*		No	ClinGen gnomAD
rs185161677 CA28944773	277	P>L		No	ClinGen 1000Genomes
CA1009600 rs765732006	279	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1009601 rs775468592	279	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs374084556 CA1009629	280	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs375968506 CA1009630	281	K>E		No	ClinGen ESP ExAC gnomAD
CA341662259 rs1175435250	282	G>S		No	ClinGen gnomAD
rs752212749 CA1009632	283	Y>N		No	ClinGen ExAC TOPMed gnomAD
rs370221833 CA1009633	284	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1009634 rs777541279	286	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA341662307 rs1304447929	289	M>V		No	ClinGen TOPMed gnomAD
CA1009637 rs369709845	290	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs369709845 CA1009636	290	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs764361211 CA1009638	290	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1436318193 CA341662327 COSM3360226	292	G>A	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1216720819 CA341662324	292	G>R		No	ClinGen gnomAD
CA341662338 rs1271088668	294	Y>C		No	ClinGen gnomAD
CA341662346 rs1223231397	295	Y>S		No	ClinGen gnomAD
rs760457102 CA1009644	298	P>H		No	ClinGen ExAC gnomAD
rs760457102 CA341662366	298	P>R		No	ClinGen ExAC gnomAD
CA1009643 rs773474689	298	P>S		No	ClinGen ExAC
rs148870988 CA1009645	299	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009646 rs148870988	299	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA28946366 COSM893964 rs150955367	299	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed gnomAD
rs1165964889 CA341662372	300	L>F		No	ClinGen TOPMed gnomAD
CA1009648 rs765231445	304	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1436613760 CA341662406	305	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	306	M>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	309	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201604439 CA1009651	309	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA341662439 rs1368720989	310	G>A		No	ClinGen gnomAD
rs1488078212 CA341662445	311	T>K		No	ClinGen TOPMed
rs751228760 CA1009652	312	S>G		No	ClinGen ExAC gnomAD
TCGA novel	317	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	317	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341662502 rs1247062117	319	E>D		No	ClinGen gnomAD
CA1009659 rs372753999	320	I>M		No	ClinGen ExAC TOPMed gnomAD
CA341662504 rs1294010518	320	I>V		No	ClinGen gnomAD
CA1009660 rs773101901	321	A>S		No	ClinGen ExAC TOPMed gnomAD
CA1009661 rs773101901	321	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1009662 rs144607229	322	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs776526998 CA1009663	322	E>D		No	ClinGen ExAC gnomAD
rs1470481130 CA341662551	326	Q>*		No	ClinGen gnomAD
TCGA novel	328	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341662592 rs1339122907	332	K>T		No	ClinGen gnomAD
CA1009683 rs377289045	334	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1238283513 CA341662615	335	N>T		No	ClinGen TOPMed
CA28947503 rs4448516	341	R>P		No	ClinGen ExAC TOPMed gnomAD
COSM1332763 CA1009685 rs4448516	341	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1009686 rs769716115	347	E>G		No	ClinGen ExAC gnomAD
CA341662723 rs1397205741	352	E>K		No	ClinGen Ensembl
rs1261096027 CA341662732	353	H>D		No	ClinGen gnomAD
rs373947278 CA1009688	353	H>R		No	ClinGen ESP ExAC gnomAD
CA341662755 rs989775366	356	R>P		No	ClinGen gnomAD
rs989775366 CA28947551	356	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1009689 rs763896855	357	H>Q		No	ClinGen ExAC gnomAD
rs1416746822 CA341662761	357	H>R		No	ClinGen gnomAD
TCGA novel	358	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341662787 rs1557764359	361	E>A		No	ClinGen Ensembl
CA341662791 rs1411801604	361	E>D		No	ClinGen gnomAD
rs773954803 CA1009690	361	E>K		No	ClinGen ExAC
CA1009691 rs199993555	362	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750072129 CA1009693	363	V>M		No	ClinGen ExAC gnomAD
CA28947577 rs912378086	365	M>V		No	ClinGen Ensembl
CA28947595 rs942568758	367	W>S		No	ClinGen Ensembl
rs753013674 CA1009696	369	P>A		No	ClinGen ExAC TOPMed gnomAD
CA341662843 rs1389684474	370	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	376	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA28947634 rs781254645	378	T>M		No	ClinGen Ensembl
rs1227922208 CA341662907	380	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	382	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341663086 rs1557765803	382	P>S		No	ClinGen Ensembl
rs943775212 CA28948897	383	G>A		No	ClinGen Ensembl
CA341663117 rs1331368928	387	S>C		No	ClinGen TOPMed gnomAD
CA341663125 rs1426571447	388	R>C	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs558568709 CA1009725	388	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs772001776 CA341663150	391	V>L		No	ClinGen ExAC TOPMed gnomAD
rs772001776 CA1009726	391	V>M		No	ClinGen ExAC TOPMed gnomAD
CA28948929 rs114362309	393	R>Q		No	ClinGen 1000Genomes
rs772742073 CA1009727	393	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341663261 rs1188458982	400	L>R		No	ClinGen TOPMed
rs776259482 CA1009730	402	S>T		No	ClinGen ExAC gnomAD
rs1056198529 CA28948956	403	S>L		No	ClinGen TOPMed
rs1570796041 CA341663332	406	H>Y		No	ClinGen Ensembl
rs554628721 CA1009734	408	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs768104788 CA1009735	410	P>L		No	ClinGen ExAC gnomAD
CA1009736 rs750581385	412	T>I		No	ClinGen ExAC gnomAD
rs1446673879 CA341663450	419	K>M		No	ClinGen gnomAD
rs1446673879 CA341663449	419	K>R		No	ClinGen gnomAD
CA1009739 rs143888387	424	R>C		No	ClinGen ESP ExAC gnomAD
CA1009740 rs755174132	424	R>H		No	ClinGen ExAC gnomAD
CA1009742 rs747937140	432	S>C		No	ClinGen ExAC gnomAD
TCGA novel	434	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1009767 rs775195870	436	R>C		No	ClinGen ExAC TOPMed gnomAD
rs775195870 CA341663575	436	R>G		No	ClinGen ExAC TOPMed gnomAD
rs748592404 CA1009768	436	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs773653752 CA1009770	438	V>M		No	ClinGen ExAC gnomAD
rs1278124080 CA341663606	441	L>V		No	ClinGen gnomAD
rs776616491 CA1009773	444	K>R		No	ClinGen ExAC gnomAD
CA341663644 rs1249783824	446	N>K		No	ClinGen TOPMed gnomAD
TCGA novel	446	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1570797455 CA341663655	448	T>P		No	ClinGen Ensembl
rs1482674228 CA341663672	450	N>T		No	ClinGen gnomAD
CA28949438 rs1026861232	451	R>C		No	ClinGen TOPMed gnomAD
rs566667009 CA1009775	451	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs566667009 CA1009774	451	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1271000315 CA341663691	453	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1009777 rs758553612	455	R>*		No	ClinGen ExAC TOPMed gnomAD
CA1009778 COSM2119950 rs763895465	455	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	458	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751314294 CA1009779	459	R>H		No	ClinGen ExAC TOPMed gnomAD
CA341663736 rs1369456396	461	L>P		No	ClinGen gnomAD
CA341663734 rs747964776	461	L>V		No	ClinGen TOPMed
TCGA novel	464	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1304244406 CA341663761	465	G>A		No	ClinGen gnomAD
CA1009783 COSM3688889 rs755646925	466	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA28949550 COSM1600561 rs144977139	466	R>H	liver [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
CA341663775 rs1316264399	467	W>C		No	ClinGen TOPMed
rs778316862 CA1009787	470	W>C		No	ClinGen ExAC TOPMed gnomAD
CA341663788 rs1570797816	470	W>G		No	ClinGen Ensembl
CA1009788 CA341663806 rs747349653	472	M>I		No	ClinGen ExAC TOPMed gnomAD
CA28949570 rs950050968	472	M>V		No	ClinGen TOPMed
rs771394471 CA1009789	473	L>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	477	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1009791 rs200051144	478	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1557766727 CA341663840	478	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1009793 rs373206941	479	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs769927111 CA1009792	479	R>W		No	ClinGen ExAC gnomAD
CA341663855 rs112768939	481	V>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs112768939 CA1009795	481	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA28949596 rs112768939	481	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1009796 rs751402225	482	P>L		No	ClinGen ExAC TOPMed gnomAD
CA28949598 rs751402225	482	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA341663876 rs1198168739	485	P>S		No	ClinGen TOPMed
rs890897754 CA28949619	486	S>*		No	ClinGen TOPMed
CA341663897 rs1164950465	487	D>Y		No	ClinGen gnomAD
rs1404166050 CA341663913	488	V>M		No	ClinGen gnomAD
CA341663929 rs1205189326	489	K>R		No	ClinGen TOPMed
CA341664030 rs1557767021	494	D>N		No	ClinGen Ensembl
CA341664047 rs775586121	495	R>P		No	ClinGen ExAC TOPMed gnomAD
rs775586121 CA1009814	495	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA1009813 rs770157691	495	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1461482495 CA341664088	498	E>D		No	ClinGen gnomAD
CA341664084 rs1267346869	498	E>G		No	ClinGen gnomAD
rs768924193 CA1009816	500	N>S		No	ClinGen ExAC gnomAD
rs761874986 CA1009818	501	P>L		No	ClinGen ExAC TOPMed gnomAD
rs761874986 CA28949866	501	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs774551277 CA1009817	501	P>S		No	ClinGen ExAC gnomAD
CA28949876 rs971504487	502	E>Q		No	ClinGen TOPMed
CA341664174 rs1570798819	505	Q>*		No	ClinGen Ensembl
rs767358480 CA1009819	505	Q>P		No	ClinGen ExAC gnomAD
rs750138719 CA1009820	508	R>K		No	ClinGen ExAC TOPMed gnomAD
rs760699545 CA1009821	511	V>I		No	ClinGen ExAC gnomAD
rs377381143 CA1009823	512	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA341664236 rs1570798927	514	T>P		No	ClinGen Ensembl
CA1009825 rs778778772	515	T>I		No	ClinGen ExAC TOPMed gnomAD
rs777118633 CA28949968	516	R>C		No	ClinGen gnomAD
rs752407299 CA1009826	516	R>H		No	ClinGen ExAC TOPMed gnomAD
rs757934734 CA1009827	518	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1428720517 CA341664275	521	I>V		No	ClinGen TOPMed
CA1009829 rs746184267	523	F>I		No	ClinGen ExAC gnomAD
CA341664325 rs1253418058	529	G>R		No	ClinGen gnomAD
CA1009831 rs780523864	533	T>M		No	ClinGen ExAC TOPMed gnomAD
CA341664355 rs780523864	533	T>R		No	ClinGen ExAC TOPMed gnomAD
CA341664972 rs764967134	550	I>M		No	ClinGen ExAC TOPMed gnomAD
CA1009849 rs749810313	550	I>V		No	ClinGen ExAC gnomAD
CA1009852 rs748146686	554	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1557767846 CA341665010	556	S>F		No	ClinGen Ensembl
rs1459432795 CA341665018	557	N>K		No	ClinGen gnomAD
rs1416814751 CA341665016	557	N>S		No	ClinGen gnomAD
rs772390323 CA1009854	559	G>A		No	ClinGen ExAC gnomAD
rs370148422 CA28950571	562	L>I		No	ClinGen ESP TOPMed gnomAD
TCGA novel	565	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773296247 CA341665076	566	R>S		No	ClinGen ExAC gnomAD
rs372683047 CA1009858	568	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA1009856 rs140221891	568	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1570800883 CA341665094	570	H>P		No	ClinGen Ensembl
rs765233250 CA1009860	570	H>Q		No	ClinGen ExAC gnomAD
CA28950615 rs374544225	570	H>Y		No	ClinGen ESP TOPMed
CA1009861 rs775111931	573	S>T		No	ClinGen ExAC gnomAD
CA1009862 rs199885350	575	I>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1488330238 CA341665133	576	Y>C		No	ClinGen TOPMed gnomAD
CA341665132 rs1488330238	576	Y>S		No	ClinGen TOPMed gnomAD
rs990746871 CA28950647	577	R>G		No	ClinGen Ensembl
CA341665139 rs1209761297	577	R>H		No	ClinGen gnomAD
rs763871620 CA1009863	578	L>V		No	ClinGen ExAC gnomAD
CA1009864 rs151323201	579	L>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009865 rs756844277	580	A>D		No	ClinGen ExAC gnomAD
CA341665158 rs1162548955	581	P>S		No	ClinGen gnomAD
rs1457523501 CA341665165	582	S>N		No	ClinGen gnomAD
CA1009868 rs746494871	583	R>K		No	ClinGen ExAC gnomAD
rs946514563 CA28950696	586	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs188207425 CA1009869	586	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1226151941 CA341665196	587	M>V		No	ClinGen gnomAD
TCGA novel	589	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1009871 rs758407447	592	I>V		No	ClinGen ExAC TOPMed gnomAD
CA341665262 rs1370678878	594	P>L		No	ClinGen TOPMed gnomAD
CA341665258 rs1276284842	594	P>S		No	ClinGen TOPMed
CA341665269 rs1431137870	595	C>Y		No	ClinGen gnomAD
rs1321440579 CA341665288	598	W>G		No	ClinGen TOPMed
CA341665290 rs1321440579	598	W>R		No	ClinGen TOPMed
rs1349189245 CA341665297	599	D>N		No	ClinGen gnomAD
rs765842366 CA1009889	600	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1369985985 CA341665324	602	K>N		No	ClinGen gnomAD
rs1217741280 CA341665329	603	G>A		No	ClinGen gnomAD
rs753151960 CA1009890	603	G>W		No	ClinGen ExAC TOPMed
rs1279667342 CA341665332	604	E>Q		No	ClinGen gnomAD
CA1009891 rs758886608	608	P>A		No	ClinGen ExAC gnomAD
CA1009892 rs777742440	608	P>H		No	ClinGen ExAC TOPMed gnomAD
rs371708913 CA1009897	609	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs371708913 CA1009896	609	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009899 rs144650909	612	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1465743811 CA341665387	612	K>T		No	ClinGen TOPMed
CA1009901 rs773774889	615	E>Q		No	ClinGen ExAC gnomAD
CA1009902 rs375776210	617	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs375776210 CA1009903	617	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA341665420 rs1314337422	617	R>W		No	ClinGen TOPMed
CA1009904 rs772850250	618	V>F		No	ClinGen ExAC gnomAD
CA341665423 rs772850250	618	V>I		No	ClinGen ExAC gnomAD
CA28951669 rs762633832	620	I>T		No	ClinGen Ensembl
rs1272567923 CA341665446	621	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA341665453 rs1365810275	623	L>F		No	ClinGen TOPMed
CA341665470 rs1409955805	625	T>N		No	ClinGen gnomAD
rs765537865 CA1009907	626	A>V		No	ClinGen ExAC gnomAD
TCGA novel	627	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341665477 rs1434807450	627	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA341665484 rs1570803766	628	R>W		No	ClinGen Ensembl
rs753636534 CA1009934	629	L>F		No	ClinGen ExAC gnomAD
CA1009937 rs748100975	634	F>L		No	ClinGen ExAC gnomAD
COSM230868 CA28951874 rs1016367515	635	P>S	Variant assessed as Somatic; impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA341665549 rs758287272	636	I>S		No	ClinGen ExAC TOPMed gnomAD
rs758287272 CA1009938	636	I>T		No	ClinGen ExAC TOPMed gnomAD
CA341665557 rs1294336052	637	D>E		No	ClinGen TOPMed gnomAD
rs750149774 CA28951881	637	D>G		No	ClinGen TOPMed gnomAD
rs777300998 CA1009939	639	F>L		No	ClinGen ExAC gnomAD
CA1009940 rs376937553	642	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs770544212 CA1009941	644	I>M		No	ClinGen ExAC gnomAD
CA341665607 rs1273300931	645	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA1009944 rs769076201	650	C>S		No	ClinGen ExAC TOPMed gnomAD
rs774806375 CA341665650	651	M>L		No	ClinGen ExAC TOPMed gnomAD
CA1009945 rs774806375	651	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1353367054 CA341665666	653	P>T		No	ClinGen TOPMed
CA341665675 rs1484957957	654	E>A		No	ClinGen gnomAD
TCGA novel	654	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs942757989 CA28951940	655	S>N		No	ClinGen TOPMed gnomAD
rs762441456 CA1009946	659	I>V		No	ClinGen ExAC
rs768106693 CA1009947	660	A>P		No	ClinGen ExAC gnomAD
rs560631173 CA28952078	661	G>A		No	ClinGen gnomAD
rs560631173 COSM2153487 CA341665730	661	G>E	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA341665744 rs1332339307	663	M>I		No	ClinGen TOPMed
CA28952093 rs916055620	664	E>G		No	ClinGen Ensembl
CA341665784 rs1427809152	669	G>V		No	ClinGen gnomAD
CA1009973 rs776528287	670	D>N		No	ClinGen ExAC gnomAD
rs1391127536 CA341665800	672	G>R		No	ClinGen gnomAD
rs1388317621 CA341665809	673	G>E		No	ClinGen gnomAD
CA341665814 rs1289970756	674	Q>*		No	ClinGen TOPMed
CA1009974 rs759838405	676	V>L		No	ClinGen ExAC gnomAD
CA341665825 rs759838405	676	V>M		No	ClinGen ExAC gnomAD
rs1228488726 CA341665840	678	A>V		No	ClinGen gnomAD
CA341665841 rs1299249120	679	G>R		No	ClinGen gnomAD
CA1009975 rs765419570	680	D>E		No	ClinGen ExAC TOPMed gnomAD
CA1009976 rs370183923	681	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1009977 rs370183923	681	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs766050330 CA341665860	682	R>L		No	ClinGen ExAC gnomAD
rs766050330 CA1009979	682	R>Q		No	ClinGen ExAC gnomAD
CA28952133 rs1044753712	682	R>W		No	ClinGen TOPMed gnomAD
rs1468261882 CA341665882	686	P>S		No	ClinGen gnomAD
CA341665886 rs1185731342	687	V>M		No	ClinGen gnomAD
CA1009980 rs757092829	689	R>H		No	ClinGen ExAC gnomAD
rs780784924 CA341665916	692	L>P		No	ClinGen ExAC gnomAD
rs780784924 CA1009981	692	L>Q		No	ClinGen ExAC gnomAD
CA341665915 rs1169594503	692	L>V		No	ClinGen TOPMed gnomAD
rs1293386264 CA341665932	695	K>Q		No	ClinGen TOPMed
CA341665945 rs1460349341	696	H>L		No	ClinGen TOPMed
rs1459188754 CA341665951	697	G>E		No	ClinGen gnomAD
rs1323722039 CA341665971	700	Y>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA341665974 rs1393261338	701	S>P		No	ClinGen gnomAD
rs375700340 CA341665980	702	L>V		No	ClinGen ESP TOPMed gnomAD
rs1425746621 CA341665984	703	L>V		No	ClinGen TOPMed gnomAD
CA28952227 rs765934294	705	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs755635865 CA1009983	705	R>W		No	ClinGen ExAC gnomAD
CA28952230 rs936312971	707	L>F		No	ClinGen gnomAD
CA341666006 rs936312971	707	L>V		No	ClinGen gnomAD
rs373394269 CA1009986	708	T>I		No	ClinGen ESP ExAC gnomAD
CA1009987 rs778199324	709	Y>S		No	ClinGen ExAC gnomAD
rs747373547 CA1009988	710	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1484899413 CA341666029	711	S>T		No	ClinGen gnomAD
CA341666045 rs1256771628	713	Y>F		No	ClinGen gnomAD
CA341666049 rs1425545378	714	K>E		No	ClinGen gnomAD
rs771236863 CA1009989	714	K>R		No	ClinGen ExAC TOPMed gnomAD
CA341666070 rs1457601383	717	P>S		No	ClinGen gnomAD
CA1009992 rs527541634	718	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA1009991 rs35168617	718	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	719	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1467082344 CA341666091	720	Y>C		No	ClinGen TOPMed
rs1380518531 CA341666095	721	D>Y		No	ClinGen gnomAD
rs763080177 CA341666107	722	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs763080177 CA1009994	722	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1292009049 CA341666109	723	Q>*		No	ClinGen gnomAD
CA341666114 rs1355164484	723	Q>H		No	ClinGen gnomAD
rs1161918173 CA341666125	725	I>V		No	ClinGen gnomAD
rs1270173919 CA341666136	726	T>I		No	ClinGen gnomAD
CA341666151 rs774195962	729	L>F		No	ClinGen ExAC gnomAD
rs774195962 CA1009996	729	L>I		No	ClinGen ExAC gnomAD
CA1009997 rs761629290 COSM1257883	730	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1009998 rs143986452	730	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341666171 rs1453745854	732	Y>C		No	ClinGen gnomAD
CA28955446 rs371391531	735	H>Y		No	ClinGen ESP
CA341666206 rs1170098716	736	P>T		No	ClinGen gnomAD
CA1010028 rs749536144	738	I>V		No	ClinGen ExAC gnomAD
CA28955468 rs955771576	741	I>V		No	ClinGen Ensembl
CA341666258 rs1409683814	744	Q>*		No	ClinGen gnomAD
rs149009106 COSM3747499 CA1010029	746	Y>C	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA28955473 rs987182217	746	Y>H		No	ClinGen Ensembl
rs778863602 CA1010030	748	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748325491 CA1010031	750	E>G		No	ClinGen ExAC gnomAD
rs773330410 CA1010033	753	A>G		No	ClinGen ExAC TOPMed
CA341666354 rs1338740130	758	V>A		No	ClinGen gnomAD
rs776369976 CA1010036	758	V>M		No	ClinGen ExAC TOPMed gnomAD
rs973077603 CA28955522	759	D>G		No	ClinGen Ensembl
rs1274865640 CA341666358	759	D>N		No	ClinGen gnomAD
CA28955524 CA1010038 rs780063037	761	E>D		No	ClinGen ExAC gnomAD
CA341666375 rs1184419449 COSM893966	762	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1184419449 CA341666374	762	R>G		No	ClinGen gnomAD
rs762575240 CA1010040	763	F>L		No	ClinGen ExAC gnomAD
CA1010042 rs767983345	765	R>C		No	ClinGen ExAC TOPMed gnomAD
CA1010043 rs151095542 RCV000968448	765	R>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1010041 rs767983345	765	R>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	767	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs115341385 CA1010044	767	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1010046 rs755150534	768	G>V		No	ClinGen ExAC TOPMed gnomAD
CA341666428 rs748152573	771	R>*		No	ClinGen ExAC gnomAD
rs748152573 CA1010048	771	R>G		No	ClinGen ExAC gnomAD
rs375102670 CA1010050	771	R>Q		No	ClinGen ESP ExAC gnomAD
CA341666433 rs1368040478	772	Q>*		No	ClinGen TOPMed
CA341666457 rs1421275242	773	G>A		No	ClinGen gnomAD
CA1010082 rs777233250	776	I>M		No	ClinGen ExAC TOPMed gnomAD
rs766846743 CA1010081	776	I>V		No	ClinGen ExAC gnomAD
CA1010085 rs373470360	781	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs764472760 CA28956073	782	M>K		No	ClinGen ExAC gnomAD
rs764472760 CA1010087	782	M>T		No	ClinGen ExAC gnomAD
rs751671796 CA341666532	785	D>H		No	ClinGen ExAC TOPMed gnomAD
CA1010088 rs751671796	785	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1254114452 CA341666549	787	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
COSM252617 rs576123899 CA28956078	787	R>H	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA341666579 rs1331391234	791	S>N		No	ClinGen gnomAD
TCGA novel	792	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341666613 rs1570811503	796	N>T		No	ClinGen Ensembl
rs1300681968 CA341666619	797	P>A		No	ClinGen TOPMed gnomAD
TCGA novel	798	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341666641 rs1346317619	800	A>P		No	ClinGen gnomAD
CA341666652 rs1570811554	802	T>P		No	ClinGen Ensembl
CA341666663 rs1570811590	803	V>G		No	ClinGen Ensembl
rs1252439557 CA341666658	803	V>L		No	ClinGen gnomAD
rs1194451257 CA341666704	810	L>F		No	ClinGen TOPMed gnomAD
rs1570811632 CA341666711	811	L>P		No	ClinGen Ensembl
CA341666715 rs1207608178	812	A>T		No	ClinGen gnomAD
rs146641181 CA1010092	813	P>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1010093 rs146641181	813	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1570811693 CA341666724	814	S>P		No	ClinGen Ensembl
CA28956132 rs774131643	817	K>E		No	ClinGen Ensembl
rs749104311 CA341666748	817	K>N		No	ClinGen ExAC gnomAD
CA341666767 rs768283807	820	A>D		No	ClinGen ExAC gnomAD
CA1010095 rs768283807	820	A>G		No	ClinGen ExAC gnomAD
CA341666770 rs1374726085	821	R>C		No	ClinGen TOPMed gnomAD
rs747624544 CA1010097	821	R>H		No	ClinGen ExAC TOPMed gnomAD
rs771600297 CA1010098	823	S>R		No	ClinGen ExAC TOPMed gnomAD
CA341666793 rs1557772441	825	R>*		No	ClinGen Ensembl
rs776951802 CA1010099	826	S>N		No	ClinGen ExAC TOPMed gnomAD
CA341666814 rs1454939512	828	G>D		No	ClinGen TOPMed gnomAD
CA1010101 rs376504097	829	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA1010102 rs775913789	831	S>Y		No	ClinGen ExAC gnomAD
CA1010103 rs370420551	832	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1010106 rs757365243	834	R>Q		No	ClinGen ExAC gnomAD
CA1010105 rs751865425	834	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	836	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	839	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA28956547 rs867755838	841	R>C		No	ClinGen TOPMed gnomAD
CA341666906 rs867755838	841	R>G		No	ClinGen TOPMed gnomAD
rs116009972 COSM1169313 CA1010131	841	R>H	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1291872039 CA341666927	844	I>V		No	ClinGen gnomAD
rs758061672 CA1010132	849	R>T		No	ClinGen ExAC gnomAD
CA341666982 rs1224497182	852	R>*		No	ClinGen gnomAD
rs573626187 CA1010133	853	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341666988 rs1185214748	853	G>R		No	ClinGen TOPMed
rs1259242884 CA341667024	858	K>M		No	ClinGen TOPMed
TCGA novel	859	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	861	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1557774105 CA341667084	865	V>A		No	ClinGen Ensembl
CA1010160 rs367907892	865	V>L		No	ClinGen ESP ExAC gnomAD
rs1557774126	867	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA341667109 rs1173071155	869	Q>K		No	ClinGen gnomAD
rs1476171944 COSM201440 CA341667140	873	R>*	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA341667151 rs1352950580	874	S>R		No	ClinGen TOPMed gnomAD
CA1010162 rs772354886	875	V>I		No	ClinGen ExAC gnomAD
CA341667164 rs1192241680	877	L>I		No	ClinGen TOPMed
CA1010163 rs773433668	878	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA28957784 rs371817602	881	V>M		No	ClinGen ESP
TCGA novel	882	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1438807058 CA341667193	882	R>G		No	ClinGen gnomAD
CA1010164 COSM3788437 rs747208248	882	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1362643393 CA341667198	883	S>G		No	ClinGen gnomAD
CA341667217 rs1210711063	885	Q>R		No	ClinGen TOPMed
rs1216099915 CA341667226	886	S>I		No	ClinGen gnomAD
rs770927906 CA1010165	888	V>L		No	ClinGen ExAC gnomAD
CA341667246 rs1311602015	889	Q>R		No	ClinGen TOPMed
CA1010167 rs759666453	891	D>G		No	ClinGen ExAC gnomAD
rs114634769 CA341667255	891	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs114634769 CA1010166	891	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA341667265 rs1276208450	892	L>P		No	ClinGen TOPMed
rs1277842211 CA341667321	900	K>N		No	ClinGen TOPMed
rs1432645012 CA341667328	901	N>I		No	ClinGen gnomAD
rs1270936545 CA341667329	901	N>K		No	ClinGen gnomAD
CA341667337 rs763811223	903	K>E		No	ClinGen ExAC gnomAD
rs763811223 CA1010171	903	K>Q		No	ClinGen ExAC gnomAD
rs758823732 CA1010196	906	N>S		No	ClinGen ExAC TOPMed gnomAD
CA341667374 rs758823732	906	N>T		No	ClinGen ExAC TOPMed gnomAD
CA1010197 rs778398108	911	R>W		No	ClinGen ExAC TOPMed
TCGA novel	912	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341667453 rs1422765637	919	V>L		No	ClinGen TOPMed
rs1422765637 CA341667451	919	V>M		No	ClinGen TOPMed
rs1314535992 CA341667469	921	N>K		No	ClinGen gnomAD
TCGA novel	921	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762760106 CA1010204	922	P>*		No	ClinGen ExAC
rs768457349 CA1010206	923	L>F		No	ClinGen ExAC TOPMed gnomAD
rs761658937 CA1010208	929	P>S		No	ClinGen ExAC gnomAD
CA1010209 rs772012793	931	W>C		No	ClinGen ExAC gnomAD
rs377196406 CA1010236	934	F>L		No	ClinGen ESP ExAC gnomAD
TCGA novel	938	C>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1371011348 CA341667621	942	G>R		No	ClinGen gnomAD
TCGA novel	944	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs996929478 CA28958418	945	T>I		No	ClinGen gnomAD
CA1010240 rs766472100	949	F>L		No	ClinGen ExAC TOPMed gnomAD
CA1010241 rs754110947	951	A>T		No	ClinGen ExAC gnomAD
rs1232762459 CA341667686	952	K>Q		No	ClinGen gnomAD
rs114753027 CA28958454 COSM3849207	952	K>T	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes
rs1488009013 CA341667717	957	Q>K		No	ClinGen TOPMed
CA28958455 rs911986294	958	G>R		No	ClinGen TOPMed gnomAD
rs1257668068 CA341667758	963	Q>K		No	ClinGen gnomAD
rs1195640235 CA341667807	970	P>S		No	ClinGen TOPMed gnomAD
rs748304296 CA1010244	971	S>T		No	ClinGen ExAC gnomAD
CA1010268 rs781038670	975	P>S		No	ClinGen ExAC gnomAD
rs970943093 CA28958655	976	H>P		No	ClinGen Ensembl
rs1363067427 CA341667863	977	S>N		No	ClinGen gnomAD
CA341667866 rs6679	977	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1010270 rs200652089	978	H>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	979	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1356309549 CA341667885	980	Y>D		No	ClinGen gnomAD
rs748758956 CA1010272	981	L>P		No	ClinGen ExAC TOPMed gnomAD
rs775164567 CA1010271	981	L>V		No	ClinGen ExAC gnomAD
CA341667900 rs1321125272	982	P>L		No	ClinGen TOPMed gnomAD
CA1010274 rs759227126	983	Q>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	983	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1010275 rs761247181	984	E>K		No	ClinGen ExAC TOPMed gnomAD
rs201257888 CA1010278 COSM293835	985	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs777040893 CA1010277	985	R>W		No	ClinGen ExAC TOPMed gnomAD
CA28958732 rs991613919	986	E>A		No	ClinGen TOPMed gnomAD
CA1010280 rs752995933	987	G>D		No	ClinGen ExAC gnomAD
rs1465267472 CA341667932	988	E>Q		No	ClinGen TOPMed
CA1010281 rs763074995	989	G>E		No	ClinGen ExAC gnomAD
rs1418461720 CA341667948	990	G>V		No	ClinGen TOPMed gnomAD
rs1450636262 CA341667988	997	P>A		No	ClinGen TOPMed gnomAD
CA341668007 rs1392010820	999	W>*		No	ClinGen gnomAD
CA341668016 rs1309311810	1000	R>S		No	ClinGen gnomAD
rs781044244 CA1010285	1003	L>F		No	ClinGen ExAC gnomAD

No associated diseases with Q9HCE1

1 regional properties for Q9HCE1

Type	Name	Position	InterPro Accession
domain	Armadillo repeat-containing domain	307 - 527	IPR006911

Functions

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Cytoplasm, P-body Cytoplasm, Cytoplasmic ribonucleoprotein granule Cytoplasm, Stress granule Nucleus Cytoplasm	Co-enriched in cytoplasmic foci with TUT4 (PubMed:30122351) In developing neurons, localizes both in nucleus and cytoplasm, but in the adulthood it is only cytoplasmic (By similarity) After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasmic ribonucleoprotein granule	A ribonucleoprotein granule located in the cytoplasm.
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P granule	A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

4 GO annotations of molecular function

Name	Definition
5'-3' RNA helicase activity	Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding	Binding to an RNA molecule or a portion thereof.

8 GO annotations of biological process

Name	Definition
3'-UTR-mediated mRNA destabilization	An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
miRNA-mediated gene silencing	A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.
miRNA-mediated gene silencing by mRNA destabilization	An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism.
negative regulation of transposition, RNA-mediated	Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate.
positive regulation of mRNA catabolic process	Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
post-transcriptional gene silencing by RNA	A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.
regulation of neuron projection arborization	Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZKD7	MOV10	Putative helicase MOV-10	Gallus gallus (Chicken)	PR
O60306	AQR	RNA helicase aquarius	Homo sapiens (Human)	PR
P23249	Mov10	Putative helicase MOV-10	Mus musculus (Mouse)	PR
Q8GYD9	SDE3	Probable RNA helicase SDE3	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MPSKFSCRQL	REAGQCFESF	LVVRGLDMET	DRERLRTIYN	RDFKISFGTP	APGFSSMLYG
70	80	90	100	110	120
MKIANLAYVT	KTRVRFFRLD	RWADVRFPEK	RRMKLGSDIS	KHHKSLLAKI	FYDRAEYLHG
130	140	150	160	170	180
KHGVDVEVQG	PHEARDGQLL	IRLDLNRKEV	LTLRLRNGGT	QSVTLTHLFP	LCRTPQFAFY
190	200	210	220	230	240
NEDQELPCPL	GPGECYELHV	HCKTSFVGYF	PATVLWELLG	PGESGSEGAG	TFYIARFLAA
250	260	270	280	290	300
VAHSPLAAQL	KPMTPFKRTR	ITGNPVVTNR	IEEGERPDRA	KGYDLELSMA	LGTYYPPPRL
310	320	330	340	350	360
RQLLPMLLQG	TSIFTAPKEI	AEIKAQLETA	LKWRNYEVKL	RLLLHLEELQ	MEHDIRHYDL
370	380	390	400	410	420
ESVPMTWDPV	DQNPRLLTLE	VPGVTESRPS	VLRGDHLFAL	LSSETHQEDP	ITYKGFVHKV
430	440	450	460	470	480
ELDRVKLSFS	MSLLSRFVDG	LTFKVNFTFN	RQPLRVQHRA	LELTGRWLLW	PMLFPVAPRD
490	500	510	520	530	540
VPLLPSDVKL	KLYDRSLESN	PEQLQAMRHI	VTGTTRPAPY	IIFGPPGTGK	TVTLVEAIKQ
550	560	570	580	590	600
VVKHLPKAHI	LACAPSNSGA	DLLCQRLRVH	LPSSIYRLLA	PSRDIRMVPE	DIKPCCNWDA
610	620	630	640	650	660
KKGEYVFPAK	KKLQEYRVLI	TTLITAGRLV	SAQFPIDHFT	HIFIDEAGHC	MEPESLVAIA
670	680	690	700	710	720
GLMEVKETGD	PGGQLVLAGD	PRQLGPVLRS	PLTQKHGLGY	SLLERLLTYN	SLYKKGPDGY
730	740	750	760	770	780
DPQFITKLLR	NYRSHPTILD	IPNQLYYEGE	LQACADVVDR	ERFCRWAGLP	RQGFPIIFHG
790	800	810	820	830	840
VMGKDEREGN	SPSFFNPEEA	ATVTSYLKLL	LAPSSKKGKA	RLSPRSVGVI	SPYRKQVEKI
850	860	870	880	890	900
RYCITKLDRE	LRGLDDIKDL	KVGSVEEFQG	QERSVILIST	VRSSQSFVQL	DLDFNLGFLK
910	920	930	940	950	960
NPKRFNVAVT	RAKALLIIVG	NPLLLGHDPD	WKVFLEFCKE	NGGYTGCPFP	AKLDLQQGQN
970	980	990	1000
LLQGLSKLSP	STSGPHSHDY	LPQEREGEGG	LSLQVEPEWR	NEL