Q8GYD9
PR
Gene name |
SDE3 (At1g05460, T25N20.11, T25N20.26) |
Protein name |
Probable RNA helicase SDE3 |
Names |
Silencing defective protein 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G05460 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GYD9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GYD9-F1 | Predicted | AlphaFoldDB |
73 variants for Q8GYD9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_1604608_G_T,A | 17 | D>E | No | 1000Genomes | |
| ENSVATH10646058 | 41 | G>S | No | 1000Genomes | |
| ENSVATH10646057 | 44 | V>L | No | 1000Genomes | |
| tmp_1_1604523_A_C | 46 | S>A | No | 1000Genomes | |
| tmp_1_1604439_T_G | 74 | T>P | No | 1000Genomes | |
| ENSVATH04524400 | 86 | Y>F | No | 1000Genomes | |
| ENSVATH10646056 | 92 | D>N | No | 1000Genomes | |
| ENSVATH13854925 | 103 | S>L | No | 1000Genomes | |
| tmp_1_1604309_G_T | 117 | T>N | No | 1000Genomes | |
| tmp_1_1604296_T_A | 121 | E>D | No | 1000Genomes | |
| ENSVATH04524395 | 138 | K>M | No | 1000Genomes | |
| ENSVATH04524393 | 141 | D>G | No | 1000Genomes | |
| ENSVATH01015763 | 193 | V>L | No | 1000Genomes | |
| ENSVATH10645653 | 210 | F>Y | No | 1000Genomes | |
| tmp_1_1603985_T_G | 225 | E>A | No | 1000Genomes | |
| ENSVATH01015762 | 228 | E>K | No | 1000Genomes | |
| tmp_1_1603964_A_T | 232 | F>Y | No | 1000Genomes | |
| ENSVATH04524391 | 235 | D>N | No | 1000Genomes | |
| tmp_1_1603726_G_A | 282 | S>F | No | 1000Genomes | |
| tmp_1_1603634_G_T | 313 | H>N | No | 1000Genomes | |
| ENSVATH04524381 | 324 | A>V | No | 1000Genomes | |
| tmp_1_1603477_C_T | 327 | V>I | No | 1000Genomes | |
| ENSVATH00007298 | 329 | M>L | No | 1000Genomes | |
| ENSVATH04524380 | 333 | S>P | No | 1000Genomes | |
| ENSVATH04524379 | 338 | R>H | No | 1000Genomes | |
| ENSVATH00007297 | 372 | N>S | No | 1000Genomes | |
| tmp_1_1603326_G_C | 377 | S>C | No | 1000Genomes | |
| ENSVATH10645646 | 380 | S>A | No | 1000Genomes | |
| tmp_1_1603309_T_A | 383 | R>W | No | 1000Genomes | |
| ENSVATH04524377 | 392 | P>L | No | 1000Genomes | |
| tmp_1_1603282_G_A | 392 | P>S | No | 1000Genomes | |
| ENSVATH04524376 | 393 | I>V | No | 1000Genomes | |
| tmp_1_1603044_C_T | 471 | R>H | No | 1000Genomes | |
| tmp_1_1602917_C_A | 513 | L>F | No | 1000Genomes | |
| tmp_1_1602913_G_T | 515 | R>S | No | 1000Genomes | |
| ENSVATH00007292 | 535 | N>K | No | 1000Genomes | |
| ENSVATH04524365 | 543 | L>F | No | 1000Genomes | |
| tmp_1_1602631_C_T | 609 | G>R | No | 1000Genomes | |
| ENSVATH13854863 | 631 | P>S | No | 1000Genomes | |
| ENSVATH10645594 | 646 | D>E | No | 1000Genomes | |
| tmp_1_1602505_G_C | 651 | L>V | No | 1000Genomes | |
| tmp_1_1602447_T_C | 670 | Q>R | No | 1000Genomes | |
| ENSVATH10645593 | 716 | R>K | No | 1000Genomes | |
| tmp_1_1602156_G_A | 767 | A>V | No | 1000Genomes | |
| tmp_1_1602111_G_T | 782 | A>D | No | 1000Genomes | |
| ENSVATH00007288 | 782 | A>S | No | 1000Genomes | |
| tmp_1_1602100_C_T | 786 | A>T | No | 1000Genomes | |
| tmp_1_1602059_T_C | 799 | I>M | No | 1000Genomes | |
| ENSVATH10645592 | 807 | K>E | No | 1000Genomes | |
| tmp_1_1601934_C_T | 811 | R>Q | No | 1000Genomes | |
| ENSVATH00007286 | 824 | P>A | No | 1000Genomes | |
| tmp_1_1601859_T_G | 836 | Q>P | No | 1000Genomes | |
| ENSVATH00007285 | 854 | S>C | No | 1000Genomes | |
| ENSVATH01015760 | 855 | G>E | No | 1000Genomes | |
| ENSVATH01015761 | 855 | G>R | No | 1000Genomes | |
| ENSVATH04524361 | 860 | G>S | No | 1000Genomes | |
| ENSVATH04524360 | 861 | G>S | No | 1000Genomes | |
| ENSVATH04524359 | 870 | D>H | No | 1000Genomes | |
| ENSVATH13854861 | 880 | E>G | No | 1000Genomes | |
| ENSVATH10645573 | 889 | N>D | No | 1000Genomes | |
| ENSVATH10645572 | 890 | S>N | No | 1000Genomes | |
| ENSVATH10645565 | 897 | K>E | No | 1000Genomes | |
| ENSVATH10645513 | 899 | D>N | No | 1000Genomes | |
| ENSVATH10645512 | 903 | D>E | No | 1000Genomes | |
| tmp_1_1601629_C_T | 913 | G>R | No | 1000Genomes | |
| tmp_1_1601602_C_T | 922 | A>T | No | 1000Genomes | |
| ENSVATH04524356 | 931 | W>* | No | 1000Genomes | |
| ENSVATH04524355 | 931 | W>C | No | 1000Genomes | |
| ENSVATH10645511 | 934 | S>I | No | 1000Genomes | |
| tmp_1_1601523_C_T | 948 | R>K | No | 1000Genomes | |
| ENSVATH04524353 | 960 | E>A | No | 1000Genomes | |
| ENSVATH04524352 | 965 | C>S | No | 1000Genomes | |
| ENSVATH00007283 | 991 | A>G | No | 1000Genomes |
No associated diseases with Q8GYD9
5 regional properties for Q8GYD9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase MOV-10/SDE3, DEXXQ/H-box helicase domain | 396 - 622 | IPR026122 |
| domain | DNA2/NAM7 helicase, helicase domain | 397 - 482 | IPR041677-1 |
| domain | DNA2/NAM7 helicase, helicase domain | 512 - 584 | IPR041677-2 |
| domain | DNA2/NAM7 helicase-like, C-terminal | 593 - 796 | IPR041679 |
| domain | Upf1-like, C-terminal helicase domain | 623 - 812 | IPR047187 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| RNAi-mediated antiviral immune response | A post-transcriptional gene silencing pathway mediated by the action of regulatory RNAs that protects against foreign organism invasion by restricting viral replication and dissemination. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSVSGYKSDD | EYSVIADKGE | IGFIDYQNDG | SSGCYNPFDE | GPVVVSVPFP | FKKEKPQSVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGETSFDSFT | VKNTMDEPVD | LWTKIYASNP | EDSFTLSILK | PPSKDSDLKE | RQCFYETFTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDRMLEPGDT | LTIWVSCKPK | DIGLHTTVVT | VDWGSDRVER | VVFLLAEDKI | SSSLTSNRPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRSRRAPKKD | FAVDDYVKGS | RPSKVVERSF | RNRLPLYEIP | KEIREMIENK | EFPDDLNEGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TARNYANYYK | TLLIMEELQL | EEDMRAYDME | NVSMKRRGIY | LSLEVPGLAE | RRPSLVHGDF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IFVRHAYDDG | TDHAYQGFVH | RVEADEVHMK | FASEFHQRHT | AGSVYNVRFT | YNRINTRRLY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QAVDAAEMLD | PNFLFPSLHS | GKRMIKTKPF | VPISPALNAE | QICSIEMVLG | CKGAPPYVIH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GPPGTGKTMT | LVEAIVQLYT | TQRNARVLVC | APSNSAADHI | LEKLLCLEGV | RIKDNEIFRL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NAATRSYEEI | KPEIIRFCFF | DELIFKCPPL | KALTRYKLVV | STYMSASLLN | AEGVNRGHFT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HILLDEAGQA | SEPENMIAVS | NLCLTETVVV | LAGDPRQLGP | VIYSRDAESL | GLGKSYLERL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FECDYYCEGD | ENYVTKLVKN | YRCHPEILDL | PSKLFYDGEL | VASKEDTDSV | LASLNFLPNK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EFPMVFYGIQ | GCDEREGNNP | SWFNRIEISK | VIETIKRLTA | NDCVQEEDIG | VITPYRQQVM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KIKEVLDRLD | MTEVKVGSVE | QFQGQEKQVI | IISTVRSTIK | HNEFDRAYCL | GFLSNPRRFN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VAITRAISLL | VIIGNPHIIC | KDMNWNKLLW | RCVDNNAYQG | CGLPEQEEFV | EEPFKQEGSS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| NGPQYPPEAE | WNNSGELNNG | GANENGEWSD | GWNNNGGTKE | KNEWSDGWNS | NGGGTKKKDE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| WSDGWDNNGG | TNGINQEGSS | NAPQDPQEAE | WNDSGEVKNG | GTKEKDVRSD | GWNNNGGKNE |
| 970 | 980 | 990 | 1000 | ||
| KEECCDGWKD | GGSGEEIKNG | GKFETRGDFV | AKEEDEWSDG | WK |