Q8CFQ3
PR
Gene name |
Aqr (Kiaa0560) |
Protein name |
RNA helicase aquarius |
Names |
Intron-binding protein of 160 kDa |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11834 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CFQ3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CFQ3-F1 | Predicted | AlphaFoldDB |
82 variants for Q8CFQ3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388570449 | 3 | A>V | No | EVA | |
| rs3388570464 | 14 | T>S | No | EVA | |
| rs3388577627 | 28 | C>S | No | EVA | |
| rs3388576069 | 61 | I>F | No | EVA | |
| rs3388576109 | 94 | I>V | No | EVA | |
| rs3392090404 | 108 | A>G | No | EVA | |
| rs216910578 | 117 | D>E | No | EVA | |
| rs28271886 | 121 | F>S | No | EVA | |
| rs232458433 | 125 | C>R | No | EVA | |
| rs28271887 | 134 | T>A | No | EVA | |
| rs3388576456 | 158 | E>G | No | EVA | |
| rs3388572032 | 191 | P>S | No | EVA | |
| rs3388583025 | 311 | F>V | No | EVA | |
| rs3388577290 | 322 | T>I | No | EVA | |
| rs28271968 | 346 | P>S | No | EVA | |
| rs3388577587 | 352 | A>P | No | EVA | |
| rs3388581640 | 369 | F>Y | No | EVA | |
| rs3388573966 | 478 | T>I | No | EVA | |
| rs3388576509 | 497 | S>Y | No | EVA | |
| rs3388576502 | 515 | V>E | No | EVA | |
| rs3388581574 | 518 | T>S | No | EVA | |
| rs3388573973 | 523 | A>T | No | EVA | |
| rs3388572327 | 560 | D>H | No | EVA | |
| rs3388576119 | 564 | L>* | No | EVA | |
| rs3388571972 | 586 | Q>H | No | EVA | |
| rs3388573544 | 596 | E>* | No | EVA | |
| rs3388577335 | 601 | L>M | No | EVA | |
| rs3388579673 | 636 | Q>R | No | EVA | |
| rs3388576441 | 637 | D>G | No | EVA | |
| rs3388570452 | 661 | P>Q | No | EVA | |
| rs3388565775 | 670 | L>S | No | EVA | |
| rs3388570458 | 671 | E>D | No | EVA | |
| rs3388573920 | 671 | E>G | No | EVA | |
| rs3388577320 | 688 | H>Q | No | EVA | |
| rs3388578158 | 764 | A>S | No | EVA | |
| rs3388573536 | 786 | N>D | No | EVA | |
| rs3388576050 | 821 | V>I | No | EVA | |
| rs3388565851 | 822 | V>L | No | EVA | |
| rs3388565851 | 822 | V>M | No | EVA | |
| rs3388573947 | 826 | G>A | No | EVA | |
| rs3388577600 | 833 | A>T | No | EVA | |
| rs3388576500 | 834 | V>D | No | EVA | |
| rs3388572298 | 839 | N>Y | No | EVA | |
| rs1132465519 | 844 | F>L | No | EVA | |
| rs1133964500 | 845 | P>A | No | EVA | |
| rs1133198204 | 845 | P>Q | No | EVA | |
| rs3388570477 | 861 | Q>H | No | EVA | |
| rs3388573546 | 919 | L>R | No | EVA | |
| rs3388565785 | 927 | Y>* | No | EVA | |
| rs226145000 | 954 | S>T | No | EVA | |
| rs241522431 | 956 | T>S | No | EVA | |
| rs3413151086 | 976 | E>V | No | EVA | |
| rs3388572312 | 1002 | F>L | No | EVA | |
| rs3392037960 | 1006 | K>E | No | EVA | |
| rs3392006664 | 1021 | L>R | No | EVA | |
| rs3391979099 | 1022 | R>S | No | EVA | |
| rs3392081216 | 1047 | A>T | No | EVA | |
| rs3391782610 | 1054 | V>A | No | EVA | |
| rs3392089523 | 1054 | V>I | No | EVA | |
| rs3392052803 | 1056 | L>S | No | EVA | |
| rs3392058272 | 1087 | D>G | No | EVA | |
| rs3391921994 | 1088 | G>* | No | EVA | |
| rs3388577657 | 1126 | R>S | No | EVA | |
| rs3388573951 | 1188 | D>V | No | EVA | |
| rs3388583037 | 1190 | Q>* | No | EVA | |
| rs3388577313 | 1249 | C>R | No | EVA | |
| rs3388580922 | 1252 | N>D | No | EVA | |
| rs3388572042 | 1292 | R>S | No | EVA | |
| rs3388565763 | 1293 | R>G | No | EVA | |
| rs3388581644 | 1293 | R>H | No | EVA | |
| rs3388579621 | 1295 | V>G | No | EVA | |
| rs3388576420 | 1296 | V>I | No | EVA | |
| rs3388576420 | 1296 | V>L | No | EVA | |
| rs3388573548 | 1316 | N>T | No | EVA | |
| rs3388581577 | 1319 | E>G | No | EVA | |
| rs3388577350 | 1320 | L>M | No | EVA | |
| rs3388579702 | 1329 | A>V | No | EVA | |
| rs3388577617 | 1340 | E>* | No | EVA | |
| rs3388581602 | 1352 | P>S | No | EVA | |
| rs3388572308 | 1366 | A>E | No | EVA | |
| rs254232066 | 1437 | A>T | No | EVA | |
| rs28286618 | 1438 | Q>R | No | EVA |
No associated diseases with Q8CFQ3
4 regional properties for Q8CFQ3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Intron-binding protein aquarius, N-terminal | 20 - 802 | IPR032174 |
| domain | DNA2/NAM7 helicase, helicase domain | 802 - 1110 | IPR041677 |
| domain | DNA2/NAM7 helicase-like, C-terminal | 1119 - 1309 | IPR041679 |
| domain | Upf1-like, C-terminal helicase domain | 1144 - 1327 | IPR047187 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| U2-type catalytic step 2 spliceosome | A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' RNA helicase activity | Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| single-stranded RNA binding | Binding to single-stranded RNA. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAPAQPKKI | VAPTVSQINA | EFVTQLACKY | WAPHIKKKSP | FDIKVIEEIY | EKEIVKSRFA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IRKIMLLEFS | QYLENYLWMN | YSPEVSSKAY | LMSICCMVNE | KFRENVPAWE | TFKKKPDHFP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFFKCILKAA | LAETDGEFSL | HEQTLLLLFL | DHCFNSLEVD | LIRSQVQQLI | SLPMWMGLQP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARLELELKKT | PKLRKFWNLI | KKNDEKMDPE | AREQAYQERR | FLSRLIQKFI | SVLKSIPLSE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PVTMDKVHYC | ERFIELMIDL | EALLPTRRWF | NTILDDSHLL | VHCYLSSLVH | REEDGHLFSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLDMLKFYTG | FEINDQTGNA | LTENEMTTIH | YDRITSLQRA | AFAHFPELYD | FALSNVAEVD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ARDSLVKFFG | PLSSNTLHQV | ASYLCLLPTL | PKNEDTTFDK | EFLLELLVSR | HERRISQIQQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LNQMPLYPTE | KIIWDENIVP | TEYYSGEGCL | ALPKLNLQFL | TLHDYLLRNF | NLFRLESTYE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRQDIEDSVS | RMKPWQSEYG | GVVFGGWARM | AQPIVAFTVV | EVAKPNIGEN | WPTRVRADVT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| INLNVRDHIK | DEWEGLRKHD | VCFLITVRPT | KPYGTKFDRR | RPFIEQVGLV | YVRGCEIQGM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LDDKGRVIED | GPEPRPNLRG | ESRTFRVFLD | PNQYQQDMTN | TIQNGAEDVY | DTFNVIMRRK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PKENNFKAVL | ETIRNLMNTD | CVVPDWLHDI | ILGYGDPSSA | HYSKMPNQIA | TLDFNDTFLS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IEHLKASFPG | HNVKVTVSDP | ALQIPPFRIT | FPVRSGKGKK | RKDADGEEDD | TEEAKTLIVE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PHVIPNRGPY | PYNQPKRNTI | QFTHTQIEAI | RAGMQPGLTM | VVGPPGTGKT | DVAVQIISNI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YHNFPEQRTL | IVTHSNQALN | QLFEKIMALD | IDERHLLRLG | HGEEELETEK | DFSRYGRVNY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VLARRIELLE | EVKRLQKSLG | VPGDASYTCE | TAGYFFLYQV | MSRWEEYMSR | VKNSGTACPD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AAPDAAQVAT | FFPFHEYFAN | APQPIFKGRS | YEEDMEIAEG | CFRHIKKIFT | QLEEFRASEL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LRSGLDRSKY | LLVKEAKIIA | MTCTHAALKR | HDLVKLGFKY | DNILMEEAAQ | ILEIETFIPL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LLQNPQDGFS | RLKRWIMIGD | HHQLPPVIKN | MAFQKYSNME | QSLFTRFVRV | GVPTVDLDAQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GRARASLCNL | YNWRYKNLGN | LPHVQLLPEF | STANAGLLYD | FQLINVEDFQ | GVGESEPNPY |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| FYQNLGEAEY | VVALFMYMCL | LGYPADKISI | LTTYNGQKHL | IRDIINRRCG | NNPLIGRPNK |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VTTVDRFQGQ | QNDYILLSLV | RTRAVGHLRD | VRRLVVAMSR | ARLGLYIFAR | VSLFQNCFEL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| TPAFSQLTAR | PLHLHIIPTE | PFPTSRKNGE | RPPHEVQVIK | NMPQMANFVY | NMYMHLIQTT |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| HHYHQTFLQL | PPAMVEEGEE | GQSQETEMEA | EEETVSAQGN | LTPSPADASL | SQETPAAQPD |
| 1450 | 1460 | 1470 | 1480 | ||
| CSSQTEDTSA | PCDIATAAEP | VSAAAEAATP | QDAESVPTET | E |