P0C5H6
PR
Gene name |
Igsf9 (Dasm1, Igsf9a) |
Protein name |
Protein turtle homolog A |
Names |
Dendrite arborization and synapse maturation protein 1, Immunoglobulin superfamily member 9A, IgSF9A |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:304982 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0C5H6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0C5H6-F1 | Predicted | AlphaFoldDB |
6 variants for P0C5H6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3322324192 | 173 | R>Q | No | EVA | |
| rs3322516620 | 298 | H>Y | No | EVA | |
| rs3322097315 | 599 | V>I | No | EVA | |
| rs3322380061 | 612 | V>I | No | EVA | |
| rs3322419694 | 616 | P>S | No | EVA | |
| rs3322324163 | 949 | P>L | No | EVA |
No associated diseases with P0C5H6
21 regional properties for P0C5H6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Immunoglobulin subtype 2 | 36 - 120 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 152 - 215 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 241 - 310 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 337 - 404 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 433 - 495 | IPR003598-5 |
| domain | Immunoglobulin subtype | 30 - 134 | IPR003599-1 |
| domain | Immunoglobulin subtype | 146 - 226 | IPR003599-2 |
| domain | Immunoglobulin subtype | 235 - 322 | IPR003599-3 |
| domain | Immunoglobulin subtype | 331 - 417 | IPR003599-4 |
| domain | Immunoglobulin subtype | 426 - 506 | IPR003599-5 |
| domain | Fibronectin type III | 232 - 302 | IPR003961-1 |
| domain | Fibronectin type III | 510 - 604 | IPR003961-2 |
| domain | Fibronectin type III | 614 - 708 | IPR003961-3 |
| domain | Immunoglobulin-like domain | 38 - 115 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 139 - 226 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 228 - 320 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 324 - 415 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 420 - 504 | IPR007110-5 |
| domain | Immunoglobulin V-set domain | 40 - 115 | IPR013106-1 |
| domain | Immunoglobulin V-set domain | 156 - 210 | IPR013106-2 |
| domain | Immunoglobulin V-set domain | 245 - 305 | IPR013106-3 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| axon | The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| inhibitory synapse | A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cell-cell adhesion mediator activity | The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| dendrite development | The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| regulation of synapse organization | Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UPX0 | IGSF9B | Protein turtle homolog B | Homo sapiens (Human) | PR |
| P13595 | Ncam1 | Neural cell adhesion molecule 1 | Mus musculus (Mouse) | PR |
| Q05BQ1 | Igsf9 | Protein turtle homolog A | Mus musculus (Mouse) | PR |
| Q62682 | Cntn3 | Contactin-3 | Rattus norvegicus (Rat) | PR |
| P13596 | Ncam1 | Neural cell adhesion molecule 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIWCLRLTIL | SLILSQGADG | RRKPEVVSVV | GRAGESAVLG | CDLLPPAGRP | PLHVIEWLRF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GFLLPIFIQF | GLYSPRIDPD | YVGRVRLQTG | ASLQIEGLRV | EDQGWYECRV | LFLDQHSPEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DFANGSWVHL | TVNSPPQFQE | TPPLVLEVKE | LEAVTLRCVA | LGSPQPYVTW | KFRGQDLGKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QGQVQVRNGT | LWIRRVERGS | AGDYTCQASS | TEGSVTHTTQ | LLVLGPPVIV | VPPNNNTVNA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQDVSLACRA | EAYPANLTYS | WFQDRINVFH | ISRLQSRVRI | LVDGSLWLQA | TQPDDAGHYT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CVPSNGFPHP | PSASAYLTVL | YPAQVTVMPP | ETPLPIGMRG | VIRCPVRANP | PLLFVTWTKD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GQALQLDKFP | GWSLGPEGSL | VIALGNEDAL | GEYSCTPYNS | LGTAGSSPVT | RVLLKAPPAF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IDQPKEEYFQ | EVGRDLLIPC | SARGDPPPIV | SWAKVGRGLQ | GQAQVDSNNS | LILRPLTKEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HGRWECSARN | AVAHVTISTN | VYVLGTSPHV | VTNVSVVPLP | KGANVSWEPG | FDGGYLQRFS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VWYTPLAKRP | DRAHHDWVSL | AVPMGATHLL | VPGLQAYTQY | QFSVLAQNKL | GSGPFSEIVL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SIPEGLPTTP | AVPRLPPTEM | PPPLSPPRGL | VAVRTPRGVL | LHWDPPELIP | ERLDGYILEG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RQGSQGWEIL | DQGVAGTEIQ | LLVPGLIKDV | LYEFRLVAFA | DSYVSDPSNI | ANISTSGLEV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YPSRTQLPGL | LPQPVLAGVV | GGVCFLGVAV | LVSILAACLM | NRRRAARRHR | KRLRQDPPLI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FSPRGRSGPH | SAPGSDSPDS | VTKFKLQGSP | VPSLRQSLLW | GEPARPPSPH | PDSPLGRGPL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PLEPICRGPD | GRFVMGPTVA | PPQEKLCLER | SEPRTSAKRL | AQSLDCSSSS | PSGVPQPLCI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TDISPVGQPP | AAMPSPLPGP | GPLLQYLSLP | FFREMNVDGD | WPPLEEPTPA | SPPDFMGSHP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| CPTSSFLPPP | DSPPTNLRAV | LPGTLMGVGV | SSEPPYTALA | DWTLRERVLP | GLLSAAPRGS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LTSQSSGRGS | ASFLRPPSTA | PSAGGSYLSP | APGDTSSWAS | GPERWPRREH | VVTVSKRRNT |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SVDENYEWDS | EFPGDMELLE | TWHPGLASSR | AHPELEPELG | VKTPEKSCLL | NTTHAPGPEA |
| 1150 | 1160 | 1170 | |||
| RCAALREEFL | AFRRRRDATR | ARLPVCQQSI | SYPEQATLL |