P13595

PR
Gene name
Ncam1 (Ncam)
Protein name
Neural cell adhesion molecule 1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17967
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

735-820 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P13595

Entry ID Method Resolution Chain Position Source
2NCM NMR - A 20-116 PDB
3NCM NMR - A 119-208 PDB
AF-P13595-F1 Predicted AlphaFoldDB

No variants for P13595

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P13595

No associated diseases with P13595

22 regional properties for P13595

Type Name Position InterPro Accession
domain Immunoglobulin subtype 2 32 - 103 IPR003598-1
domain Immunoglobulin subtype 2 130 - 196 IPR003598-2
domain Immunoglobulin subtype 2 226 - 295 IPR003598-3
domain Immunoglobulin subtype 2 321 - 393 IPR003598-4
domain Immunoglobulin subtype 2 418 - 487 IPR003598-5
domain Immunoglobulin subtype 26 - 115 IPR003599-1
domain Immunoglobulin subtype 124 - 209 IPR003599-2
domain Immunoglobulin subtype 220 - 306 IPR003599-3
domain Immunoglobulin subtype 315 - 404 IPR003599-4
domain Immunoglobulin subtype 412 - 499 IPR003599-5
domain Fibronectin type III 499 - 599 IPR003961-1
domain Fibronectin type III 601 - 696 IPR003961-2
domain Immunoglobulin-like domain 20 - 111 IPR007110-1
domain Immunoglobulin-like domain 116 - 189 IPR007110-2
domain Immunoglobulin-like domain 212 - 302 IPR007110-3
domain Immunoglobulin-like domain 309 - 402 IPR007110-4
domain Immunoglobulin-like domain 407 - 492 IPR007110-5
domain Immunoglobulin I-set 21 - 114 IPR013098-1
domain Immunoglobulin I-set 217 - 305 IPR013098-2
domain Immunoglobulin I-set 414 - 493 IPR013098-3
domain Immunoglobulin V-set domain 230 - 290 IPR013106-1
domain Immunoglobulin V-set domain 325 - 388 IPR013106-2

Functions

Description
EC Number
Subcellular Localization
  • [Isoform 1]: Cell membrane; Single-pass type I membrane protein
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

15 GO annotations of cellular component

Name Definition
anchored component of membrane The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cell surface The external part of the cell wall and/or plasma membrane.
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
integral component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.

3 GO annotations of molecular function

Name Definition
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
LRR domain binding Binding to a LRR domain (leucine rich repeats) of a protein.
phosphatase binding Binding to a phosphatase.

21 GO annotations of biological process

Name Definition
aging A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
axonal fasciculation The collection of axons into a bundle of rods, known as a fascicle.
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
commissural neuron axon guidance The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
homotypic cell-cell adhesion The attachment of a cell to a second cell of the identical type via adhesion molecules.
learning or memory The acquisition and processing of information and/or the storage and retrieval of this information over time.
modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
multicellular organismal response to stress Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
negative regulation of cell death Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
regulation of exocyst assembly Any process that modulates the frequency, rate or extent of exocyst assembly.
regulation of semaphorin-plexin signaling pathway Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway.
regulation of sensory perception of pain Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
response to cocaine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
response to lead ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
thalamus development The process in which the thalamus changes over time, from its initial formation to its mature state.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UPX0 IGSF9B Protein turtle homolog B Homo sapiens (Human) PR
Q05BQ1 Igsf9 Protein turtle homolog A Mus musculus (Mouse) PR
P0C5H6 Igsf9 Protein turtle homolog A Rattus norvegicus (Rat) PR
P13596 Ncam1 Neural cell adhesion molecule 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLRTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE
70 80 90 100 110 120
KLSPNQQRIS VVWNDDDSST LTIYNANIDD AGIYKCVVTA EDGTQSEATV NVKIFQKLMF
130 140 150 160 170 180
KNAPTPQEFK EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK
190 200 210 220 230 240
KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTVQARQSI VNATANLGQS VTLVCDADGF
250 260 270 280 290 300
PEPTMSWTKD GEPIENEEED DEKHIFSDDS SELTIRNVDK NDEAEYVCIA ENKAGEQDAS
310 320 330 340 350 360
IHLKVFAKPK ITYVENQTAM ELEEQVTLTC EASGDPIPSI TWRTSTRNIS SEEKTLDGHM
370 380 390 400 410 420
VVRSHARVSS LTLKSIQYTD AGEYICTASN TIGQDSQSMY LEFQYAPKLQ GPVAVYTWEG
430 440 450 460 470 480
NQVNITCEVF AYPSATISWF RDGQLLPSSN YSNIKIYNTP SASYLEVTPD SENDFGNYNC
490 500 510 520 530 540
TAVNRIGQES LEFILVQADT PSSPSIDRVE PYSSTAQVQF DEPEATGGVP ILKYKAEWKS
550 560 570 580 590 600
LGEESWHFKW YDAKEANMEG IVTIMGLKPE TRYSVRLAAL NGKGLGEISA ATEFKTQPVR
610 620 630 640 650 660
EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVKYR ALASEWKPEI RLPSGSDHVM
670 680 690 700 710 720
LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP ANGSPTAGLS TGAIVGILIV
730 740 750 760 770 780
IFVLLLVVMD ITCYFLNKCG LLMCIAVNLC GKAGPGAKGK DMEEGKAAFS KDESKEPIVE
790 800 810 820 830 840
VRTEEERTPN HDGGKHTEPN ETTPLTEPEL PADTTATVED MLPSVTTVTT NSDTITETFA
850 860 870 880 890 900
TAQNSPTSET TTLTSSIAPP ATTVPDSNSV PAGQATPSKG VTASSSSPAS APKVAPLVDL
910 920 930 940 950 960
SDTPTSAPSA SNLSSTVLAN QGAVLSPSTP ASAGETSKAP PASKASPAPT PTPAGAASPL
970 980 990 1000 1010 1020
AAVAAPATDA PQAKQEAPST KGPDPEPTQP GTVKNPPEAA TAPASPKSKA ATTNPSQGED
1030 1040 1050 1060 1070 1080
LKMDEGNFKT PDIDLAKDVF AALGSPRPAT GASGQASELA PSPADSAVPP APAKTEKGPV
1090 1100 1110
ETKSEPPESE AKPAPTEVKT VPNDATQTKE NESKA