O93257
PR
Gene name |
XRCC6 (G22P1, KU70) |
Protein name |
X-ray repair cross-complementing protein 5 |
Names |
5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP/AP lyase Ku70, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, DNA repair protein XRCC6, Ku autoantigen protein p70 homolog, Ku70 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:395767 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O93257
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O93257-F1 | Predicted | AlphaFoldDB |
No variants for O93257
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O93257 | |||||
No associated diseases with O93257
No regional properties for O93257
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O93257 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| Ku70:Ku80 complex | Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. |
| nonhomologous end joining complex | A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5'-deoxyribose-5-phosphate lyase activity | Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| damaged DNA binding | Binding to damaged DNA. |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| telomeric DNA binding | Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to gamma radiation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. |
| cellular response to X-ray | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). |
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| double-strand break repair via nonhomologous end joining | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P12956 | XRCC6 | X-ray repair cross-complementing protein 6 | Homo sapiens (Human) | PR |
| P23475 | Xrcc6 | X-ray repair cross-complementing protein 6 | Mus musculus (Mouse) | PR |
| Q7F1M0 | KU70 | ATP-dependent DNA helicase 2 subunit KU70 | Oryza sativa subsp japonica (Rice) | PR |
| Q9FQ08 | KU70 | ATP-dependent DNA helicase 2 subunit KU70 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMWVLGEVG | MAVLSAAAMA | DWVSYYRGDG | PDEEEDGEQQ | EEEGPEAVAD | YRFSGRDSLI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLVDASKAMF | EPYENEEAAT | PFDMTMQCIR | NVYTSKIISS | DKDLLSVVFY | GMENNKNSAD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FKHIYVLQEL | DNPGAKRILE | LDQYRGDEGR | VLFRETFGHN | ADYSLGEALW | ACSNLFSDVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VRLSHKRIML | FTNEDNPHAN | DSAKAKLART | RAGDLRDTGI | ILDLMHLKKP | GGFDISLFYR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DIINVAEDED | LGIQPDESGK | LEHLMKKVRA | KETRKRALSR | LNLYLNKDLS | FSVGVYNLIQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KAYKPYPVKL | YRETNEPVKT | KTRVFNGKTG | SLLLPSDTKR | AQTYGNRQIA | MEKEETEEVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RFDSPGLFLI | GFKPLSMLKQ | HHHIRPSQFM | YPEESLVTGS | TTLFNALLMK | CLEKEVMALC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RYIARRNTPP | RIVALIPQEE | EVDEQKVQIA | PPGFHIIFLP | YADDKRNVDF | TEKVPANREQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VDKMKGIIQK | LRFKYRTDSF | ENPVLQQHFR | NLEALALDML | EPEQAEDLTM | PKTEEMSRRL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GNLVEEFKQL | VYPPDYSPEG | KAAKRKQAGD | AQAEKRPKIE | ISEDSLRSYV | QNGTLGKLTV |
| 610 | 620 | 630 | |||
| SALKDTCRHY | GLRSGGKKQE | LIDALTEYFS | GR |