Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for O65821

Entry ID Method Resolution Chain Position Source
AF-O65821-F1 Predicted AlphaFoldDB

No variants for O65821

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O65821

No associated diseases with O65821

1 regional properties for O65821

Type Name Position InterPro Accession
domain Histone H2A/H2B/H3 4 - 118 IPR007125

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
structural constituent of chromatin The action of a molecule that contributes to the structural integrity of chromatin.

1 GO annotations of biological process

Name Definition
nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96A08 H2BC1 Histone H2B type 1-A Homo sapiens (Human) PR
P70696 H2bc1 Histone H2B type 1-A Mus musculus (Mouse) PR
Q9SF55 At3g09480 Histone H2B.5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LZ45 At5g02570 Histone H2B.9 Arabidopsis thaliana (Mouse-ear cress) PR
O65818 H2B-2 Histone H2B.2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MAPKAGKKPA EKKPVEEKKA EEVPAEKKPK AGKKLPKDAG ADKKKKKSKK SVETYKIYIF
70 80 90 100 110 120
KVLKQVHPDI GISSKSMGIM NSFINDIFEK LAQESSRLAR INKKPTITSR EIQTAVRLVL
130 140
PGELAKHAVS EGTKAVTKFT SN