D4A1R8
PR
Gene name |
Cpne1 |
Protein name |
Copine-1 |
Names |
Copine I |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:362249 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for D4A1R8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-D4A1R8-F1 | Predicted | AlphaFoldDB |
1 variants for D4A1R8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs105051526 | 66 | Y>H | No | EVA |
No associated diseases with D4A1R8
5 regional properties for D4A1R8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 113 | IPR000008-1 |
| domain | C2 domain | 122 - 244 | IPR000008-2 |
| domain | von Willebrand factor, type A | 282 - 484 | IPR002035 |
| domain | Copine, C-terminal | 250 - 517 | IPR010734 |
| domain | Copine, C2B domain | 137 - 244 | IPR037768 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| aggresome | An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. |
| identical protein binding | Binding to an identical protein or proteins. |
| NF-kappaB binding | Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. |
| phosphatidylserine binding | Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to calcium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| negative regulation of DNA binding | Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of NIK/NF-kappaB signaling | Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling. |
| neuron projection extension | Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| positive regulation of neuron differentiation | Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
| positive regulation of protein kinase B signaling | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of tumor necrosis factor-mediated signaling pathway | Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| regulation of I-kappaB kinase/NF-kappaB signaling | Any process that modulates I-kappaB kinase/NF-kappaB signaling. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08DB4 | CPNE1 | Copine-1 | Bos taurus (Bovine) | PR |
| O75131 | CPNE3 | Copine-3 | Homo sapiens (Human) | PR |
| Q99829 | CPNE1 | Copine-1 | Homo sapiens (Human) | PR |
| Q8BT60 | Cpne3 | Copine-3 | Mus musculus (Mouse) | PR |
| Q8C166 | Cpne1 | Copine-1 | Mus musculus (Mouse) | PR |
| D4A1R8 | Cpne1 | Copine-1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAHCVTLVQL | SVSCDHLIDK | DIGSKSDPLC | VLLQDVGGAW | AELCRTERVR | NCSSPAFSKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQIEYYFETV | QKLRFGIYDI | DNKTPELGDD | DFLGGAECSL | GQIVSSQTLT | LPLMLKPGKP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGRGTITVSA | QELKDSRVVT | MEVEARNLDK | KDFLGKSDPF | LEFFRQGDGK | WHLAYRTEVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KNNLNPTWKR | FSVSLQHFCG | GDLNTPIQVR | CSDYDSDGSH | DLIGTFHTTL | AQLQAVPAEF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ECIHPEKQQR | KKSYKNSGTV | CVKTCRVETE | YSFLDYVMGG | CQINFTVGVD | FTGSNGDPSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDSLHYLSPT | GVNEYLTALW | SVGSVVQDYD | SDKLFPAFGF | GAQVPPDWQV | SHEFALNFNP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNPYCAGIQG | IVDAYRQALP | QVRLYGPTNF | APIINHVARF | AAQAAQQRTA | SQYFVLLLLT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DGAVTDVEAT | CKAVVEASKL | PMSVIIVGVG | GADFEVMEQL | DADGGPLRTR | SGEAAARDIV |
| 490 | 500 | 510 | 520 | 530 | |
| QFVPYRRFQN | APRETLAMTV | LAEVPTQMVS | YFKAQGWAPL | KTLPAPAKGP | AQAPQV |