Q08DB4

PR
Gene name
CPNE1
Protein name
Copine-1
Names
Copine I
Species
Bos taurus (Bovine)
KEGG Pathway
bta:615677
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

76-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08DB4

Entry ID Method Resolution Chain Position Source
AF-Q08DB4-F1 Predicted AlphaFoldDB

78 variants for Q08DB4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs436498095 2 A>P No EVA
rs474371401 3 H>N No EVA
rs454324547 3 H>P No EVA
rs434236763 4 C>W No EVA
rs451958474 5 V>G No EVA
rs465668204 5 V>L No EVA
rs465668204 5 V>M No EVA
rs437577222 6 T>P No EVA
rs468820929 6 T>S No EVA
rs448868412 7 L>M No EVA
rs480122274 9 Q>R No EVA
rs466560490 15 D>A No EVA
rs1115267027 22 I>V No EVA
rs446622829 31 V>G No EVA
rs444327634 39 G>C No EVA
rs451053854 40 N>I No EVA
rs479993807 94 L>I No EVA
rs719638905 124 R>Q No EVA
rs474305904 132 Q>* No EVA
rs454188181 139 V>E No EVA
rs721650922 144 V>L No EVA
rs440586622 152 K>E No EVA
rs442293635 153 D>G No EVA
rs473009204 155 L>V No EVA
rs432831213 175 A>T No EVA
rs470662266 175 A>V No EVA
rs452407379 228 H>L No EVA
rs876085239 233 Q>K No EVA
rs876021876 233 Q>L No EVA
rs876358406 234 L>M No EVA
rs876290639 234 L>P No EVA
rs109308606 332 S>A No EVA
rs443302029 333 D>G No EVA
rs474686934 335 L>Q No EVA
rs440971345 338 A>S No EVA
rs472464257 339 F>C No EVA
rs452278155 344 Q>E No EVA
rs432277112 345 V>L No EVA
rs464347265 346 P>H No EVA
rs43711945 374 D>N No EVA
rs470738638 375 A>P No EVA
rs525776685 386 F>Y No EVA
rs1114386813 407 N>D No EVA
rs457140022 407 N>S No EVA
rs437032189 410 N>T No EVA
rs467008645 413 Q>P No EVA
rs446854999 420 L>M No EVA
rs478118495 423 G>C No EVA
rs464534529 425 V>G No EVA
rs450994671 436 V>L No EVA
rs442322976 438 A>D No EVA
rs462409199 438 A>T No EVA
rs479427558 440 Y>F No EVA
rs43711946 448 V>L No EVA
rs449170839 456 E>K No EVA
rs435704987 460 Q>* No EVA
rs714442375 464 D>N No EVA
rs439288025 465 G>A No EVA
rs457078288 467 P>A No EVA
rs474838925 472 S>A No EVA
rs473345680 473 G>A No EVA
rs434680838 473 G>W No EVA
rs453175801 476 A>G No EVA
rs464471199 477 A>P No EVA
rs464471199 477 A>S No EVA
rs468824344 479 D>G No EVA
rs448636138 481 V>L No EVA
rs445663215 487 R>L No EVA
rs460041906 487 R>W No EVA
rs477030407 488 R>L No EVA
rs463412851 489 F>S No EVA
rs434963129 507 T>K No EVA
rs466386173 511 S>C No EVA
rs452778159 513 F>L No EVA
rs449661434 518 W>G No EVA
rs481106671 520 P>R No EVA
rs467475031 530 G>D No EVA
rs447310627 531 P>R No EVA

No associated diseases with Q08DB4

5 regional properties for Q08DB4

Type Name Position InterPro Accession
domain C2 domain 1 - 114 IPR000008-1
domain C2 domain 123 - 245 IPR000008-2
domain von Willebrand factor, type A 283 - 485 IPR002035
domain Copine, C-terminal 251 - 518 IPR010734
domain Copine, C2B domain 138 - 245 IPR037768

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cell membrane
  • Translocates to the cell membrane in a calcium-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
aggresome An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
identical protein binding Binding to an identical protein or proteins.
NF-kappaB binding Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

10 GO annotations of biological process

Name Definition
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
negative regulation of DNA binding Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of NIK/NF-kappaB signaling Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
neuron projection extension Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
positive regulation of neuron differentiation Any process that activates or increases the frequency, rate or extent of neuron differentiation.
positive regulation of protein kinase B signaling Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of tumor necrosis factor-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of I-kappaB kinase/NF-kappaB signaling Any process that modulates I-kappaB kinase/NF-kappaB signaling.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O75131 CPNE3 Copine-3 Homo sapiens (Human) PR
Q99829 CPNE1 Copine-1 Homo sapiens (Human) PR
Q8BT60 Cpne3 Copine-3 Mus musculus (Mouse) PR
Q8C166 Cpne1 Copine-1 Mus musculus (Mouse) PR
D4A1R8 Cpne1 Copine-1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAHCVTLVQL SVSCDHLIDK DIGSKSDPLC VLLQDVGGGN WTELGRTERV QNCSSPEFSK
70 80 90 100 110 120
TLQLEYHFET VQKLRFGIYD IDNKTPELGD DDFLGGAECS LGQIVSSRML TLPLMLKPGK
130 140 150 160 170 180
PAGRGTITVS AQELKDNRVV TMEVEARNLD KKDFLGKSDP FLEFFRQGDG KWHLAYRSEV
190 200 210 220 230 240
IKNNLNPTWK RFSVPLQHFC GGDASTPIQV RCSDYDSDGS HDLIGTFHTS LAQLQAAPAE
250 260 270 280 290 300
FECIHPEKQQ KKKSYKNSGT ICVKMCQVET EHSFLDYVMG GCQINFTVGV DFTGSNGDPS
310 320 330 340 350 360
SPDSLHYLSP TGVNEYLTAL WSVGSVVQDY DSDKLFPAFG FGAQVPPDWQ VSHEFALNFN
370 380 390 400 410 420
PSNPFCAGIQ GIVDAYRQAL PQVRLFGPTN FAPIINHVAR FAAQAANQRN ASQYFVLLLL
430 440 450 460 470 480
TDGAVTDVEA TREAVVRASY LPMSVIIVGV GCADFEAMEQ LDADGGPLHT RSGEAAARDI
490 500 510 520 530
VQFVPYRRFQ NAPREALAQT VLAEVPTQLV SYFRAQGWAP FKPPPPAAKG PAQAPQA