Q8BT60
PR
Gene name |
Cpne3 |
Protein name |
Copine-3 |
Names |
Copine III |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70568 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BT60
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BT60-F1 | Predicted | AlphaFoldDB |
19 variants for Q8BT60
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388670282 | 63 | F>S | No | EVA | |
| rs3393743624 | 65 | I>T | No | EVA | |
| rs3388674684 | 121 | K>I | No | EVA | |
| rs3388675783 | 128 | I>F | No | EVA | |
| rs3388655202 | 165 | F>L | No | EVA | |
| rs3388669150 | 181 | E>K | No | EVA | |
| rs3393964424 | 188 | N>Y | No | EVA | |
| rs215787527 | 190 | M>I | No | EVA | |
| rs27697673 | 242 | S>N | No | EVA | |
| rs3388678007 | 258 | K>R | No | EVA | |
| rs3388673365 | 260 | S>G | No | EVA | |
| rs3388668751 | 363 | M>K | No | EVA | |
| rs244456010 | 367 | P>S | No | EVA | |
| rs3388655145 | 442 | V>F | No | EVA | |
| rs13469673 | 451 | I>V | No | EVA | |
| rs3388678593 | 481 | V>M | No | EVA | |
| rs3388674690 | 487 | V>F | No | EVA | |
| rs254246182 | 523 | K>R | No | EVA | |
| rs234676041 | 532 | V>A | No | EVA |
No associated diseases with Q8BT60
5 regional properties for Q8BT60
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1 - 115 | IPR000008-1 |
| domain | C2 domain | 124 - 247 | IPR000008-2 |
| domain | von Willebrand factor, type A | 289 - 495 | IPR002035 |
| domain | Copine, C-terminal | 263 - 524 | IPR010734 |
| domain | Copine, C2B domain | 139 - 251 | IPR037768 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| focal adhesion | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
| calcium-dependent protein binding | Binding to a protein or protein complex in the presence of calcium. |
| metal ion binding | Binding to a metal ion. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| receptor tyrosine kinase binding | Binding to a receptor that possesses protein tyrosine kinase activity. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to calcium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. |
| cellular response to growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. |
| ERBB2 signaling pathway | The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
5 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAQCVTKVE | LNVSCNNLLD | ADVTSKSDPL | CVLFLNTSGH | QWYEVERTER | IKNSLNPKFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KTFVIDYYFE | VVQKLKFGIY | DIDNKTIELS | DDDFLGECEV | TLGQIVSSKK | LTRPLVLKNG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KPAGKGSITI | SAEEIKDNRV | VLFEMEARKL | DNKDLFGKSD | PYLEFHKQTS | DGHWLMVHRT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVIKNNLNPM | WKPFKISLNS | LCYGDMDKTI | KVECYDYDND | GSHDLIGTFQ | TTMTKLKEAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RSSPVEYECI | NEKKRQKKKS | YKNSGVISVK | HCEITVECTF | LDYIMGGCQL | NFTVGVDFTG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNGDPSSPDS | LHYISPNGVN | EYLTAIWSVG | LVIQDYDADK | MFPAFGFGAQ | VPPQWQVSHE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPMNFNPSNP | YCNGIQGIVE | AYRTCLPQIR | LYGPTNFSPI | INHVARFAAA | ATQQQTASQY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FVLLIITDGV | ITDLDETRQA | IVNAAKLPMS | IIIVGVGGAD | FSAMEFLDGD | GGSLRAPSGE |
| 490 | 500 | 510 | 520 | 530 | |
| VAIRDIVQFV | PFRQFQNAPK | EALAQCVLAE | IPQQVVGYFN | TYKLLPPKNP | AVK |