C7J0A2
Gene name |
TOP3A (Os03g0165000, LOC_Os03g06900, OJ1123F12.5) |
Protein name |
DNA topoisomerase 3-alpha |
Names |
|
Species |
Oryza sativa subsp japonica (Rice) |
KEGG Pathway |
osa:9269718 |
EC number |
5.6.2.1: Enzymes altering nucleic acid conformation |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for C7J0A2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-C7J0A2-F1 | Predicted | AlphaFoldDB |
No variants for C7J0A2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for C7J0A2 | |||||
No associated diseases with C7J0A2
9 regional properties for C7J0A2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, CCHC-type | 909 - 925 | IPR001878 |
| domain | DNA topoisomerase, type IA, domain 2 | 150 - 251 | IPR003601 |
| domain | DNA topoisomerase, type IA, DNA-binding domain | 297 - 557 | IPR003602 |
| domain | TOPRIM domain | 11 - 158 | IPR006171 |
| domain | Zinc finger, GRF-type | 806 - 847 | IPR010666 |
| domain | DNA topoisomerase, type IA, central | 121 - 134 | IPR013497-1 |
| domain | DNA topoisomerase, type IA, central | 175 - 605 | IPR013497-2 |
| active_site | DNA topoisomerase, type IA, active site | 334 - 348 | IPR023406 |
| domain | DNA topoisomerase 3-like, TOPRIM domain | 11 - 171 | IPR034144 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.6.2.1 | Enzymes altering nucleic acid conformation |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA topoisomerase activity | Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. |
| DNA topoisomerase type I (single strand cut, ATP-independent) activity | Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA topological change | The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P13099 | TOP3 | DNA topoisomerase 3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q13472 | TOP3A | DNA topoisomerase 3-alpha | Homo sapiens (Human) | PR |
| O70157 | Top3a | DNA topoisomerase 3-alpha | Mus musculus (Mouse) | PR |
| Q9LVP1 | TOP3A | DNA topoisomerase 3-alpha | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHHGGGGGAI | RVLNVAEKPS | VAKSVAEILS | RPSGGMRSRE | GRSRYNRVFE | FDYSIGGRAC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HMLVTSVTGH | LMELEFDDRF | RRWHSCDPAD | LFHAPVRKSV | PQDKQDIKRT | LEEEARKCQW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LVLWLDCDRE | GENIAYEVID | ICAGANSRLN | IWRARFSALI | DREIHEAVQH | LDRPNKLFAD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVDARQEIDL | RIGASFTRFQ | TMLLKDAFVL | DDTGDDRNII | LSYGPCQFPT | LGFIVERFWE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IQAHEPEEFW | TINCSHTSDE | GTASFGWIRG | HLFDYSSAVV | IYEMCVEEPM | ATVQNVRNQE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLKYPPYPLS | TIELQKRASR | YFRMSSEHTM | KVAEELYQAG | FISYPRTETD | NFSPNTDLHS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IVHEQVAHPN | WGTYAQRLLD | PEARLWRNPS | NGGHDDKAHP | PIHPTKFSAG | ETNWTDNHKK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LYELVVRHFL | ACCSQPAVGA | ETTVEIDIAG | EQFNASGRVV | LAKNYLDVYR | FDSWGGTLLP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TYIIGQQFVP | TTLTLDSGMT | RPPPLLAEAD | LLGCMDKAGI | GTDATMHDHI | KKLLDRCYAT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDANTRFSPT | NLGEALVMGY | DEMGYELWKP | YLRSMMEADM | KSVSIGTKSK | SEVLENCLQQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MKACFLDARA | NKVKLFDAMG | TFFARSSRPV | NETQNSIETV | RPCAACNESE | MFLKQRPTGE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FMVGCRGFPQ | CRNVVWLPRS | LSGAAVTDQV | CPTCAPGPVY | KIQFKFRRRD | IPPNFDVDHL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GCIGGCDDIL | KELMELSRFG | SHSQTATPAR | NQSQTASGVR | QGSSRQDLHT | SFHPAVQFTN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GQTPVVNPQG | FRSTHTQSSG | NASGQVQCTS | CREPCVLRTA | NTEANRGRKF | YKCQNLACGF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FAWEDDVENS | APRGRGGRGR | GGRSSSRQSS | ASASAGRRGG | TQGRGRRGRG | RNADGMMFVA |
| 910 | 920 | ||||
| ATGEPVYGSC | FICGDPTHFA | NVCPNLGR |